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    The antioxidant effect of chitosan on virgin and mated Drosophila females
    (Elsevier, 2023) Gunes, Eda; Nizamlioglu, Hatice Ferhan
    Mating causes decreased life span and oxidative damage in female Drosophila. We investigated the effect of under mating and virginity oxidative stress-induced damage and soluble Chitosan (Ch) supplementation. It was determined as antioxidant capacity (TAS) and total oxidation (TOS), triacylglycerol (TAG), protein and glycogen concentration of Ch (1-20 mg/mL) on young-old mated and virgin flies (Drosophila melanogaster). We were found that females of mating and aging groups feeding with Ch were lower levels of stress. Feeding with high con-centrations of Ch in aging decreased the amount of TAG and glycogen, while increasing the amount of protein. The study suggests that higher antioxidant defenses in virgin and old females confer resistance to oxidative stress, because of feeding with 20% Ch. Data shows that mating status affects fly physiology and metabolism in free radical processes.
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    Investigation of the protective effect of acetazolamide and SLC-0111 on carbon tetrachloride-induced toxicity in fruit fly
    (Elsevier, 2021) Gunes, Eda; Aydin, Hasan; Nizamlioglu, Hatice Ferhan
    Sulfonamide-based compounds in the development of drugs used in cancer treatment have been started to be investigated recently. In the current work, it was determined the protective effect of Acetazolamide (AAZ) and SLC-0111 on carbon tetrachloride-induced toxicity in the fruit fly (Drosophila melanogaster). AAZ and SLC-0111 were used as a nonselective and selective inhibitor of carbonic anhydrase isozymes, respectively, to compare the selectivity effect of drugs on toxicity. The experimental toxicity was created by carbon tetrachloride (CCl4) that causes tissue damage to the first stage larvae of fruit fly and used as a model organism. The effect of AAZ and SLC-0111 on toxicity of insect survival, sex ratio, longevity and some biochemical parameters such as Malondialdehyde-MDA content, Superoxide dismutase-SOD and Glutathione-S-transferase-GST activity were tested. According to the data obtained, feeding of insects with AAZ and SLC-0111 (2.5 and 10 mM, respectively) affected their survival and development positively against the toxicity induced by CCl4. Compared to the control group, GST and SOD activity was higher in pups and adults (SLC-0111 < AAZ). Because of this study, SLC-0111 is thought to be useful in protecting against the harmful effects of reactive oxygen species.