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    Cilostazol-induced relaxation of calf cardiac vein and coronary artery during cooling
    (Comenius Univ, 2013) Nurullahoglu-Atalik, K. E.; Nurullahoglu, Z. U.; Kilic, M.; Aribas, A.
    Objective: At present very little is known about the role of endothelial nitric oxide (NO) in the effects of temperature on vascular reactivity. The aim of the present study is to evaluate the influence of cooling (to 28 degrees C) on the vasodilatation induced by cilostazol(10(-9)-3x10(-4)M) on carbachol (10(-6))-precontracted calf cardiac vein and coronary artery and the role of NO in these effects. Materials and methods: Ring preparations of great cardiac vein and the anterior interventricular branch of left coronary artery were used. Results: Cilostazol produced concentration-dependent relaxation of calf cardiac vein and coronary artery rings precontracted with carbachol. During cooling, the pIC(50) values, but not the maximal responses to cilostazol were significantly lower than at 37 degrees C in both preparations. Cooling to 28 degrees C in the presence of N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) did not modify the effect of temperature both in cardiac vein and coronary artery. These results demonstrate for the first time that cooling-induced changes of cilostazol in calf cardiac vein and coronary artery are independent of NO (Tab. 2, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.
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    Donepezil-induced response of Spirulina supplemented rat urinary bladder
    (Comenius Univ, 2013) Nurullahoglu-Atalik, K. E.; Okudan, N.; Gokbel, H.; Nurullahoglu, Z. U.
    Objective: At present, very little is known about the effects of donepezil on vascular reactivity. The aim of the present study was to evaluate the responses of rat urinary bladder to donepezil (10(-10)-3x10(-4) M) and the role of Spirulina supplementation in these effects. Material and methods: Animals were divided into the two groups of six animals in each group. The first group received only distilled water daily as vehicle for six weeks and served as the control. The second group received Spirulina 750 mg kg (-1) orally, daily for six weeks and served as the spirulina group. Preparations of rat urinary bladder were used from both groups. Results: Donepezil produced concentration dependent relaxation of rat urinary bladder preparations pre-contracted with KCl. The pIC(50) value, but not the maximal response of donepezil, was significantly lower (p<0.05) in the Spirulina supplemented group. Conclusions: These results demonstrated for the first time that spirulina treatment can affect urinary bladder activity (Fig. 1, Ref. 20). Full Text in PDF www.elis.sk.