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    Demographic, Clinical and Echocardiographic Characteristics of Children with Chest Wall Deformities
    (Galenos Yayincilik, 2017) Aslan, Eyup; Sert, Ahmet; Sap, Fatih; Aypar, Ebru; Odabas, Dursun
    Introduction: To determine the demographic, clinical and echocardiographic characteristics of children with chest wall deformities. Methods: The patients diagnosed with chest wall deformities were investigated retrospectively in the pediatric cardiology unit over a period of three years. The study enrolled 205 children under the age of 18 years diagnosed with chest wall deformities. Results: The mean age of the patients was 7.6 +/- 4.5 years with a median of 8 years. One hundred and sixty four (80 %) patients with chest wall deformities were found to have normal echocardiography results. Incidental echocardiographic diagnoses included 10 (4.87%) atrial septal defects, 8 (3.90%) mitral valve prolapses, 7 (3.41%) mild mitral regurgitations, 5 (2.44%) bicuspid aortic valve without aortic valve stenoses, 4 (1.95%) ventricular septal defects, 2 (0.98%) mild aortic regurgitations, 2 (0.98%) dextrocardia, 2 (0.98%) coarctations of the aorta and 1 (0.49%) complex cardiac defect (pulmonary atresia and VSD). Compression in the right heart was evaluated by echocardiography 15 (7.3%). Discussion and Conclusion: Because chest wall deformities are associated with congenital heart defects in children and may cause compression in the right heart, evaluation by echocardiography can ensure an optimal management of the defects.
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    Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome
    (Cambridge Univ Press, 2019) Aslan, Eyup; Sert, Ahmet; Buyukinan, Muammer; Pirgon, Mustafa Ozgur; Kurku, Huseyin; Yilmaz, Hakan; Odabas, Dursun
    Purpose: The aim of our study was to assess left ventricle and right ventricle systolic and diastolic functions in obese adolescents with metabolic syndrome using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotis intima-media thickness, and asymmetric dimethyl arginine levels. Methods: A total of 198 obese adolescents were enrolled in the study. The obese patients were divided into metabolic syndrome group and non-metabolic syndrome group. All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulsed, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness. Results: Obese adolescents were characterised by enlarged left end-diastolic, end-systolic and left atrial diameters, thicker left and right ventricular walls compared with non-obese adolescents. The metabolic syndrome group had normal left ventricle systolic function, impaired diastolic function, and altered global systolic and diastolic myocardial performance. In the metabolic syndrome obese group patients, left ventricle mass was found positively correlated with body mass index, waist and hip circumferences, diastolic blood pressure, age, and waist-to-hip circumference ratio. The carotid intima-media thickness was found positively correlated with waist and hip circumferences and total cholesterol levels. Asymmetric dimethyl arginine levels were found positively correlated with systolic blood pressure, waist-to-hip circumference ratio, and diastolic blood pressure. Conclusions: The results of this study demonstrate that metabolic syndrome in adolescence is associated with significant changes in myocardial geometry and function. In addition, it has been associated with a high level of asymmetric dimethyl arginine concentration and thicker carotid intima-media thickness reflecting endothelial dysfunction.
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    Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio May Be Used as Predictors in Febrile Seizures
    (Georg Thieme Verlag Kg, 2018) Yazar, Abdullah; Akin, Fatih; Ture, Esra; Caksen, Huseyin; Odabas, Dursun
    Febrile seizure (FS) is the most frequent seizure disorder in childhood, associated with rapid onset of high fever. Our study aims are (1) to determine if the levels of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) are risk factors for FS and to (2) assess the usefulness of these markers as predictors to distinguish the subgroups of FS. This prospective study includes children with FS, acute febrile illness (AFI) without seizure, and control group. Complete blood count was performed on all participants. The following data were obtained: white blood cell count (WBC), platelet count, MPV, hemoglobin (Hb), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), and NLR. MPV, WBC, ANC, and NLR were significantly increased in patients with AFI and FS compared with controls (p < 0.05). When patients with FS and AFI were compared, only WBC was increased significantly in patients with FS (p < 0.05). WBC, ANC, and NLR were significantly increased in patients with complex FS compared with simple (p < 0.05). Our findings showed that WBC, MPV, ANC, and NLR were higher in children with FS than in the control group. Additionally WBC, ANC, and NLR were found to be higher in children with CFS than in those with simple febrile seizure. Based on the study results, we suggest that only WBC may be used as predictors in children with FS.