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Öğe Association between syndecan-4 and subclinical atherosclerosis in ankylosing spondylitis(Lippincott Williams & Wilkins, 2024) Sertdemir, Ahmet L.; Sahin, Ahmet T.; Duran, Mustafa; Celik, Mustafa; Tatar, Sefa; Oktay, Irem; Alsancak, YakupBackground: Despite advances in the diagnosis and treatment of ankylosing spondylitis (AS), the risk of cardiovascular complications in AS patients is still higher than in the general population. Macrophages are at the intersection of the basic pathogenetic processes of AS and atherosclerosis. Although syndecan-4 (SDC4) mediates a variety of biological processes, the role of SDC4 in macrophage-mediated atherogenesis in AS patients remains unclear. Herein, we aimed to investigate the role of SDC4 in subclinical atherosclerosis in AS patients.Methods: Subjects were selected from eligible AS patients and control subjects without a prior history of AS who were referred to the rheumatology outpatient clinics. All participants' past medical records and clinical, and demographic characteristics were scanned. In addition, carotid intima-media thickness (CIMT) measurement and disease activity index measurement were applied to all patients.Results: According to our data, serum SDC4 level was significantly higher among AS patients compared with the control group (6.7 [1.5-35.0] ng/mL vs 5.1 [0.1-12.5] ng/mL, P < .001). The calculated CIMT was also significantly higher in AS patients than in the control group (0.6 [0.3-0.9] mm vs 0.4 (0.2-0.7), P < .001]. Additionally, serum C-reactive protein level and SDC4 level were independent predictors of AS and strongly associated with CIMT. Linear regression analysis showed that serum SDC4 level was the best predictor of CIMT (P = .004).Conclusion: Our data indicate that serum SDC4 levels provide comprehensive information about the clinical activity of the disease and subclinical atherosclerosis in AS patients.Öğe A Case of Acute Coronary Syndrome Under Immunosuppression Who is the Criminal Neutrophils or T Cells?(Emergency Medicine Physicians Assoc Turkey, 2022) Oktay, Irem; Sertdemir, Ahmet Lutfu; Icli, AbdullahChronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent, life-threatening bacterial and fungal infections of the skin, airways, lymph nodes, liver, brain, and bones. These infections most commonly occur in organs in contact with the outside world (lungs, gastrointestinal tract, and skin), as well as in lymph nodes that drain these structures. While involvement can be seen in many organs, there is no known cardiovascular involvement. Our case is an ACS case that has a different place in the literature because acute coronary syndrome (ACS) was seen in a twenty years old male patient with a diagnosis of chronic granulomatous disease.Öğe Effect of Pericardial Effusion on Right Ventricular Functions in Oncology Patients Receiving Chemotherapy(Galenos Publ House, 2023) Tatar, Sefa; Yavuz, Yunus Emre; Oktay, Irem; Aydin, Nergiz; Alsancak, Yakup; Icli, AbdullahIntroduction: Pericardial effusion is an indicator of poor prognosis in patients with cancer. We investigated the effect of pericardial effusion development on right ventricular function in oncology patients receiving chemotherapy for malignancy. Methods: A total of 90 patients who were followed up in the oncology clinic and who applied to our outpatient clinic for routine cardiac examination were included in the study. Echocardiography was performed on the patients, and they were divided into two groups: patients with and without pericardial effusion. Demographic characteristics and, clinical and laboratory findings of the patients were recorded. The right ventricular functions of the patients were then evaluated. Results: Pericardial effusion was in 30 (33.3%) of 90 patients included in the study. The mean age of patients without pericardial effusion was 57.33 +/- 15.59, and the mean age of patients with effusion was 60.27 +/- 13.51, and it was similar between the groups (p=0.36). No statistically significant difference was detected between the groups in right ventricular (RV) fractionated area change, RV-early peak, tricuspid annular plane systolic excursion, pulmonary artery pressure, E/E', and heart failure with preserved ejection fraction values, which are parameters that indicate right ventricular functions and diastolic dysfunction. However, RV systolic velocity and RV-AM, which are indicators of diastolic dysfunction, were found at higher rates in the patient group with pericardial effusion (p-value 0.041 and 0.001, respectively). In addition, Mitral E velocity was found to be lower in the patient group with pericardial effusion (p=0.032). Conclusion: In malignancy patients who develop pericardial effusion, we recommend that diastolic parameters be checked and close clinical follow-up of the patients be performed before overt heart failure clinic develops. It should be kept in mind that the development of pericardial effusion in oncology patients receiving chemotherapy does not mean right ventricular failure.Öğe Rare Case of Coronary Anomaly, Overview of Hypertrophic Cardiomyopathy with A Different Presentation(Emergency Medicine Physicians Assoc Turkey, 2023) Oktay, Irem; Kesriklioglu, Serhat; Soylu, AhmetCoronary artery anomalies are uncommon cardiac diseases. It is mostly detected incidentally in the adult population as well as being usually asymptomatic. Although its prevalence is low, its association with atherosclerosis, arrhythmias, and hypertrophic cardiomyopathy is important for sudden cardiac death. According to the literature, the association of hypertrophic cardiomyopathy with the coronary anomaly is rare. No case of hypertrophic cardiomyopathy accompanied by the absence of the left anterior descending artery has been reported. Therefore our case is special and valuable..
