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Öğe Co-administration of cisplatin and curcumin does not alter mood-associated behaviors(Comenius Univ, 2016) Demir, E. A.; Oz, M.; Alp, M., I; Gergerlioglu, H. S.; Atalik, Nurullahoglu K. E.; Yerlikaya, F. H.OBJECTIVES: Cisplatin (cis-diamminedichloroplatinum (II)) is a widely-used platinum-based chemotherapeutic agent which has dose-limiting side-effects. Also, the drug resistance is another instance that decreases treatment success in cisplatin chemotherapy. The growing body of evidence suggests that curcumin, a polyphenolic compound extracted from the spice turmeric, may exert synergistic effects and sensitize malign cells to cisplatin, while alleviating cytotoxicity-related side-effects. The present study was aimed to investigate mood-associated interactions between cisplatin and curcumin. MATERIALS AND METHODS: Thirty-four adult male Wistar albino rats were randomly assigned to four groups as control, curcumin (300 mg/kg/day, p.o. for 5 weeks), cisplatin (5 mg/kg/week, i.p. for 5 weeks), and curcumin plus cisplatin (same doses as above). The open field, elevated plus maze, and forced swim tests were engaged to evaluate mood-associated behaviors. RESULTS: We demonstrated that depression- and anxiety-like behaviors were not altered by the administration of curcumin along with the chronic cisplatin treatment. CONCLUSION: According to the results of the present study, we concluded that curcumin might be regarded as a safe adjuvant in cisplatin chemotherapy in terms of the mood-associated behaviors (Fig. 4, Ref 41).Öğe The comparison of preemptive analgesic effects of curcumin and diclofenac(Comenius Univ, 2014) Atalik, Nurullahoglu K. E.; Okudan, N.; Belviranli, M.; Oz, M.Objective: Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of curcumin and diclofenac, before acute and inflammatory induced pain in rat model. Material and methods: Fourty eight old female (n = 6 in each group) Wistar Albino rats were included in the study. Paw movements in response to paw flinching in response to formalin injection or thermal stimulation were compared after curcumin (400 mg kg(-1), p.o.) and diclofenac (10 mg kg(-1), i.p.) administration. Saline was used as a control. The solvent ethanol was administered in another group of rats. Preemptive analgesic effect was significant in both tests when curcumin and diclofenac was administrated before the pain stimuli. Results: Oral administration of curcumin and intraperitoneal injection of diclofenac increase the response time in hot plate test and decrease the number of flinches in formalin test (p < 0.001 vs p < 0.05). Conclusion: These results suggest that curcunnin had preemptive analgesic effects on acute thermal, and inflammatory induced pain in rats as diclofenac (Fig. 2, Ref. 35). Text in PDF www.elis.sk.Öğe Effects of exercise preconditioning on intestinal ischemia-reperfusion injury(Comenius Univ, 2014) Gokbel, H.; Oz, M.; Okudan, N.; Belviranli, M.; Esen, H.Background: To investigate the effects of exercise preconditioning on oxidative injury in the intestinal tissue of rats. Methods: Sixty male Wistar rats were randomly divided into six groups as sham (n = 10), ischemia-reperfusion (n = 10), exercise (n = 10), exercise plus ischemia-reperfusion (n = 10), ischemic preconditioning (n = 10), and ischemic preconditioning plus ischemia-reperfusion groups (n = 10). Tissue levels of malondialdehyde and activities of myeloperoxidase and superoxide dismutase, and serum levels of tumor necrosis factor-alpha and interleukin-6 were measured. Intestinal tissue histopathology was also evaluated by light microscopy. Results: Tumor necrosis factor-alpha concentrations significantly decreased in the exercise group compared to the sham group (p < 0.05). Myeloperoxidase activity significantly increased and superoxide dismutase activity significantly decreased in ischemia-reperfusion group compared to the sham group (p < 0.05). Superoxide dismutase activity in the ischemic preconditioning and ischemic preconditioning plus ischemia-reperfusion groups were significantly higher compared to the ischemia-reperfusion and exercise groups (p < 0.05). Histopathologically, intestinal injury significantly attenuated in the exercise plus ischemia-reperfusion group compared to the ischemia-reperfusion group. Conclusions: The results of the present study indicate that exercise training seems to have a protective role against intestinal ischemia-reperfusion injury (Tab. 3, Fig. 1, Ref. 35). Text in PDF www.elis.sk.Öğe The role of nitric oxide on the responses of curcumin-treated rat aorta(Comenius Univ, 2012) Nurullahoglu-Atalik, K. E.; Gokbel, H.; Oz, M.; Okudan, N.; Belviranli, M.; Esen, H.Objectives: The aim of the present study was to evaluate the influence of endothelial nitric oxide (NO) on the vascular responses of curcumin-treated rats. Methods: The experimental groups included the control and curcumin-treated (200 mg/kg/day, p.o., for 4 weeks) group. The concentration response curves to receptor-dependent agent 5-hydroxytryptamine (5-HT; 10(-9)-3x10(-4) M) and receptor-independent agent potassium chloride (KCl; 5-100 mM) were observed. Results: The concentration response curves to 5-HT and KCl shifted to the right and the maximal response was significantly decreased in the curcumin-treated rat aortas. A pretreatment of rings with L-NAME (a NOS inhibitor, 10(-4) M) increased both the sensitivity and maximal response to only 5-HT. No apparent histological changes were demonstrated in smooth muscle and connective tissue layers in the aortas of the control and curcumin-treated rat preparations. Conclusion: The results of the present study suggest that NO release from endothelial cells modulates curcumin-treated rat aorta responses to 5-HT, but not to KCl (Tab. 2, Fig. 4, Ref. 25). Full Text in PDF www.elis.sk.Öğe Rosuvastatin-induced responses in calf cardiac vein(Comenius Univ, 2015) Nurullahoglu-Atalik, K. E.; Oz, M.; Shafiyi, A.OBJECTIVE: The effects of Rho-kinase inhibitors on vasodilatation induced by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor rosuvastatin (10(-9)-10(-4)M) on 5-HT-precontracted calf cardiac vein and the role of endothelium in these effects were analyzed. MATERIAL AND METHODS: Cardiac vein ring preparations were suspended in organ baths containing 25 ml of Krebs Henseleit solution, maintained at 37 degrees C and continuously gassed with 95 % O-2-5 % CO2. At the end of the resting period, the cardiac vein preparations were contracted with 10(-6) M 5-HT. After the contraction had reached a steady state, rosuvastatin was added to the organ bath cumulatively (10(-9)-10(-4)M). RESULTS: Rosuvastatin relaxed the cardiac vein rings in general while the degree of relaxation was greater in those with endothelium and lower in those without it. HA1077 [1-(5-isoquinolinesulfonyl)-homopiperazine] (Fasudil, 10(-6) M) and Y-27632 [(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexane carboxamide dihydrochloride] (10(-6) M) incubation increased the rosuvastatin-induced relaxation only in the presence of endothelium. CONCLUSIONS: The results demonstrate for the first time that in calf cardiac vein, rosuvastatin induced endothelium-dependent relaxations while Rho-kinase inhibition increased these relaxations in the presence of endothelium layer (Fig. 3, Ref. 44). Text in PDF www.elis.sk.
