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    The effects of vitamin D supplementation during pregnancy and maternal vitamin D levels on neonatal vitamin D levels and birth parameters
    (Taylor & Francis Ltd, 2018) Kilicaslan, Ayse Ozlem; Kutlu, Ruhusen; Kilinc, Ibrahim; Ozberk, Derya Isiklar
    Objective: The current study aimed to measure the levels of vitamin 25(OH)D in pregnant women and in the umbilical cord blood of newborns and to evaluate the association of vitamin D levels with birth parameters.Methods: This cross-sectional analytic investigation was performed in 100 pregnant women at term and in 100 newborns born to these mothers. Plasma vitamin D level was measured and birth parameters of the babies were recorded.Results: Mean vitamin D levels in pregnant women and cord blood were 11.396.24ng/ml and 8.00 +/- 4.95ng/ml, respectively. Vitamin D levels were found to be higher in the women who had received vitamin D support during pregnancy (p<.001). Height (p=.004), head circumference (p=.003), and chest circumference (p=.005) of newborns born to mothers who had received vitamin D support were higher compared to non-receivers. Maternal vitamin D deficiency (<10ng/ml) and insufficiency (10-30ng/ml) was detected in 53.0% and 47.0% of the cases, respectively. None of the women had sufficient levels of vitamin D.Conclusions: This study established that vitamin D levels were low in maternal and cord blood in spite of the administration program of Ministry of Health in pregnant women. The importance of vitamin D supplementation should be explained to the pregnant women in each visit.
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    Incidence of Metabolic Syndrome and Long-Term Chronic Health Problems in Infertile Women
    (Istanbul Training & Research Hospital, 2017) Kutlu, Ruhusen; Ozberk, Derya Isiklar; Gorkemli, Huseyin
    Introduction: Infertility is a condition wherein there is no pregnancy within 1 year despite regular sexual intercourse without birth control. The aim of this study was to evaluate the incidence of metabolic syndrome (MetS) and chronic long-term health problems in infertile female patients. Methods: This cross-sectional and analytical study was retrospectively conducted on 701 women who applied to family medicine outpatient clinic and received a medical report with the complaint of female infertility. The weight, height, waist circumference, blood pressure, and laboratory results of subjects were recorded from the information in the files. MetS was diagnosed according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) guideline. Results: The mean age of the 701 infertile women in the study was 29.9 +/- 4.4 (20-42) years; 81.6% (n=572) were housewives and 56.8% (n=398) completed primary school and were undergraduates. Of the patients, 78.9% (n=553) were admitted due to primary infertility. The incidence of MetS was 19.8% in the subjects of this study. The risk of MetS was 6,389 times higher in obese than in non-obese individuals [ odds ratio (OR)=6,389; % 95 confidence interval (CI): (4,260-9,581)], and this difference was statistically significant (p<0.001). The most common MetS components were triglyceride elevation (59.6%) and fasting blood glucose (55.0%). MetS was detected in 50.3% of hypertensive patients. Of the participants, 22.8% had hypothyroidism and 2.7% were found to have brucella seropositivity. Conclusion: Obesity, long-term health problems, smoking, and some infectious diseases, which are among the replaceable factors associated with infertility, should be excluded before infertility treatment. Healthy lifestyle changes such as well-balanced and correct nutrition, physical activity, giving up smoking and alcohol will reduce the risk of obesity and increase the chances of infertility treatment.