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Öğe The effect of intraurethral dexpanthenol in hypospadias repair: experimental rabbit study(Elsevier Sci Ltd, 2019) Karakan, T.; Ozcan, S.; Bagcioglu, M.; Aydin, A.; Doluoglu, O. G.; Yucel, M. O.; Adali, Y.Introduction In this study, the authors aimed to research the histopathologic effects of intraurethral use of dexpanthenol for hypospadias repair. Dexpanthenol is a derivative of pantothenic acid, a B complex vitamin. Pantothenic acid is a molecule contributing in the structure of coenzyme A. It decreases the release of myeloperoxidase from granulocytes and inhibits the formation of free oxygen radicals, and it exhibits an anti-inflammatory effect by increasing mitotic activity. Objective The objective of this study is to evaluate the use of dexpanthenol after a tubularized incised plate urethroplasty (TIP) on wound healing, inflammation, and fibrosis. Study design In this study, 18 healthy male New Zealand white rabbits weighing 2500-3000 g were used. The 18 rabbits were randomly divided into 3 groups. For the hypospadias model, rabbits had a urethral catheter inserted in the urethra and a ventral midline incision was made from the glans tip to the central line of the penis. Afterward, the incision was closed with Vicryl (7/0) using the continuous suture technique, and urethroplasty was completed. For fourteen days, group I had 0.9% saline solution administered intraurethrally twice per day with a 22G catheter sleeve (control group), group II had one dose of 500 mg/kg dexpanthenol (Bepanthene (R); Bayer Turk Chemical Industry Limited Company, Turkey) ampoule and one dose of saline solution administered in the same way, and group III had two doses of 500 mg/kg dexpanthenol ampoule administered. On the fifteenth day, the penis was degloved and rabbits had penectomy performed with samples sent to the pathology department for histopathological assessment. Results The degree of fibrosis and inflammation in group I (control group) was more severe than groups II and III. The differences between groups I and II were statistically significantly different for both fibrosis and inflammation (P = 0.018 and P = 0.041, respectively). The differences between groups I and III were also statistically significantly different for both fibrosis and inflammation (P = 0.019 and P = 0.011, respectively). Groups II and III were not different significantly for fibrosis and inflammation (P > 0.05). Discussion This study shows that intraurethral dexpanthenol application has positive effects on fibrosis and inflammation. The main limitations of the study are that the hypospadias model was created surgically and long-term follow-up for fistula formation was not assessed. Conclusions Administration of intraurethral dexpanthenol after hypospadias repair has positive effects on fibrosis and inflammation.Öğe Influence of lupin (Lupinus albus L.) yoghurt on mineral content and functional properties of tarhana(Wageningen Academic Publishers, 2014) Ertas, N.; Bilgicli, N.; Ozcan, S.; Sari, S.Tarhana is a fermented cereal-yoghurt-vegetable based product that contains high amounts of protein, mineral and vitamin. In this research, lupin yoghurt (LY) was produced from fermented lupin milk, and replaced with cow's milk yoghurt up to 100% (w/w) level in tarhana formulation. LY substitution increased protein content of final product from 13.12% up to 14.87%. The redness (a*), yellowness (b*) and hue values of tarhana samples changed significantly (P<0.05) with LY usage. Tarhana samples prepared with 100% LY had the lowest a* and b*, and the highest hue values. Tarhana containing high amounts of LY had rich copper, iron, manganese and zinc contents compared to control tarhana. Especially manganese content of the tarhana increased up to 177 times with LY substitution. While LY over 25% level improved the functional properties such as foaming capacity, water absorption capacity and emulsifying activity of tarhana samples, foaming stability was negatively affected by LY substitution. Colour, taste, consistency, sourness and overall acceptability scores decreased at high substitution levels of LY.Öğe Three-dimensional volumetric analysis of the maxillary sinus: a cone-beam computed tomography study(Via Medica, 2020) Gulec, M.; Tassoker, M.; Magat, G.; Lale, B.; Ozcan, S.; Orhan, K.Background: This study aimed to determine the volumetric size of the maxillary sinus and investigate the effect of gender and age on maxillary sinus volume (MSV) using cone-beam computed tomography (CBCT) images in a Turkish subpopulation. Materials and methods: This retrospective volumetric CBCT study was carried out on 133 individuals (84 females, 49 males) between 8 and 51 years old. MSV was measured using the MIMICS 21.0 software (Materialise HQ Technologielaan, Leuven, Belgium). All statistical analyses were performed using the SPSS 21.0 (SPSS, Chicago, IL, USA) software. Mean and standard deviation of both maxillary sinuses measurements were calculated and compared to gender and age. P values < 0.05 were considered to indicate statistical significance. Results: Mean volume of the right maxillary sinus was 13.173 cm(3), while for the left was 13.194 cm(3). There was no significant difference between right and left maxillary sinus volumes (p > 0.05). There was no significant correlation between MSV and age (p > 0.05). It was found that MSV did not change according to gender (p > 0.05). Conclusions: Right and left maxillary sinus volumes were not different from each other. Gender and age were not found to be related to maxillary sinus volume.
