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Öğe Assessment of orthorexia nervosa via ORTO-R scores of Turkish recreational and competitive athletes and sedentary individuals: a cross-sectional questionnaire study(Springer, 2021) Ozdengul, Faik; Yargic, Melda Pelin; Solak, Rabia; Yaylali, Oguzhan; Kurklu, Galip BilenPurpose This study aims to evaluate and compare the scores of a self-reported measurement of orthorexia nervosa among Turkish people who engage in different levels of physical activity (sedentary individuals, recreational athletes and competitive athletes). Methods Data for this study were collected through a self-administered online questionnaire between March and April 2020 in Turkey. The questionnaire consisted of two parts: personal information (sociodemographic and anthropometric information, training and dieting regime) and the ORTO-11 Scale. Only the items in the revised scale (ORTO-R) were used for analysis. Measurement invariance was tested and latent means were compared across different activity groups, sexes and levels of education. Results Analysis was done with a total of 877 participants (514 sedentary, 271 recreationally active, and 91 competitive athletes). Mean age of participants was 29.12 +/- 11.15. Sedentary people were less likely to follow a particular diet. Configural, metric and partial scalar invariance were proven across three groups of physical activity and the difference between latent means was found nonsignificant (competitive vs sedentary: CR = - 0.53,p = 0.592; competitive vs recreational: CR = 0.25,p = 0.724; sedentary vs. recreational: CR = - 1.35,p = 0.183). Configural, metric and full scalar invariance were proven across sexes and different levels of education, and difference between latent means was found nonsignificant (CR = - 1,11,p = 0.272; CR = - 0.53,p = 0.587, respectively). Conclusion In conclusion, people who compete at sports events, exercise regularly at a recreational level, or lead a sedentary life have similar scores in ORTO-R. Also, females did not score higher than males.Öğe Brain-Derived Neurotrophic Factor Levels in Mesenchymal Stem Cell Culture Fluid Under Different Culture Conditions(Aves, 2023) Cicek, Gulsemin; Cicek, Muharrem; Ozen, Emine Utlu; Aktan, T. Murad; Ozdengul, Faik; Duman, SelcukObjective: Mesenchymal stem cells are used in various fields, such as cellular therapy, regeneration, or tissue engineering. It has been shown that they exhibit many protective factors and also work as a modulating chief within the region in which they are administered. There are studies on both the therapeutic and neuroprotective effects of brain-derived neurotrophic factor. Also, there are many studies on the improvement of culture conditions for in vitro reproduction of mesenchymal stem cells, which can be obtained from many sources in various bodies, such as adipose tissue and Wharton's jelly. Improving and standardizing these culture conditions will increase the effectiveness and reliability of stem cell therapies. Studies evaluating many culture conditions, such as O-2 level, type of medium, monolayer culture, and the transition from in vitro 3D models, are ongoing. Materials and Methods: In our study, groups were formed by using stem cells originating from adipose tissue and Wharton's jelly. Stem cell cultures were made using Hillex-II and Pronectin-F microcarriers. Cell culture O-2 level was adjusted as 1% and 5% for each group separately. Enzyme-linked immunosorbent assay was used to analyze brain-derived neurotrophic factor levels in stem cell culture fluid. Results: The highest brain-derived neurotrophic factor level in mesenchymal stem cells culture medium was observed in an adipose-derived stem cell culture with an in vitro fertilization (non-treated) dish, using a Hillex microcarrier in a 1% O 2 microenvironment. Conclusion: As a result of our observations, we think that cells could exhibit greater therapeutic potential in a dynamic adhesion environment.Öğe Does Pregabalin Affect Renal Functions and Plasma Electrolytes?(Wiley, 2023) Gunay, Ahmet Can; Gormus, Z. Isik Solak; Gunay, Merve Akgul; Koca, Raviye Ozen; Ozdengul, Faik[Abstract Not Availabe]Öğe Effect of Naloxone Precipitated Morphine Withdrawal on Melatonin Receptor Expressions in Hippocampus and Hypothalamus Tissues in Morphine Dependent Rat(Karger, 2021) Cimen, Yasin Ali; Gunes, Canan Eroglu; Yildiz, Ibrahim; Ozdengul, Faik; Kurar, Ercan; Meral, Ismail; Kutlu, Selim[Abstract Not Availabe]Öğe The Effect of Yarrow Extracts on Uterine Contractions Isolated from Non-pregnant Rats(Wiley, 2019) Ozdengul, Faik[Abstract Not Availabe]Öğe Effects of Fluoxetine in Healty and Damaged Rat Aorta(Wiley, 2018) Taki, Fatma Nur; Solak, Hatice; Koca, Raviye Ozen; Ozdengul, Faik; Gormus, Z. Isik Solak; Kutlu, Selim[Abstract Not Availabe]Öğe Effects of Sertralin on in Vitro Rat Uterus Contractions(Wiley, 2018) Ozdengul, Faik; Koca, Raviye Ozen; Taki, Fatmanur; Solak, Hatice; Gormus, Z. Isik Solak; Kutlu, Selim[Abstract Not Availabe]Öğe Evaluation of Histopathological Effects of Acamprosate Use on Kidneys in Alcohol-Dependent Rats(Aves, 2023) Ozdengul, Faik; Gultekin, Burcu; Kusen, Hande; Karakus, Behiye Nur; Sen, AysuObjective: Alcohol addiction is one of the growing global addiction threads. The present study aims to investigate histopathological effects of acamprosate, which is widely used in the treatment of alcohol dependence, on kidneys. Methods: Rats were divided into 4 groups. The control group was given 10 mg/kg/day saline, and the alcohol group was given 10 mg/kg/day ethanol, diluted with 10 mg/kg/day saline. To the acamprosate group, 200 mg/kg/day acamprosate diluted with 10 mg/kg/day saline was given. The alcohol + acamprosate group was given 10 mg/kg/day ethanol diluted with 10 mg/kg/day saline, then combined with 200 mg/kg/day acamprosate. On the 21st day, after the study began, signs of alcohol withdrawal syndrome in the rats were evaluated. On the 22nd day, kidney tissues of the rats were extracted. Results: Histopathological evaluation revealed that kidney tissues of the control group had normal structure. It was determined that Bowman's spaces were close to normal in kidneys of the alcohol group. In kidneys of the acamprosate group, an increased Bowman's space distance and intense tubular degeneration, shedding in tubule epithelial cells, and tubular dilatation were detected (P <.05). In kidneys of the alcohol + acamprosate group, Bowman's space distance was better than the acamprosate group, but tubular degeneration, shedding in tubule epithelial cells, and tubular dilatation continued (P <.05). Our findings revealed that the use of acamprosate alone produced serious histopathological consequences for kidneys. Conclusion: It has been understood that it is important to control kidney health at certain intervals during the period of alcohol-dependent individuals without any kidney disease receiving acamprosate treatment.Öğe Investigation of the effect of trazodone on spontaneous and acetylcholine-induced bladder detrusor smooth muscle contractions(Kare Publ, 2022) Burunsuz, Ozge; Ozdengul, Faik; Gica, Sakir; Sen, Aysu; Sahin, ZaferObjective: The management of psychiatric patients is often complicated by medical comorbidities, complex pharmacological regimens, and side effects secondary to these regimens. In the current study, it was aimed to investigate the effects and mechanism of action of trazodone on rat bladder smooth muscle contractility in vitro. Method: Sixteen adult male Wistar albino rats were euthanized by the cervical dislocation method following ether anesthesia. Two muscle strips of 2x10 mm in size were prepared vertically from the bladder by opening a longitudinal incision from the neck of the bladder in the direction of the apex. The strips were tied properly and hung in the organ bath. All contraction amplitudes and frequencies were recorded. After a 45-min adaptation period, contractions were induced by applying 10(-5) M acetylcholine (ACh) to all spontaneously contracting bladder strips. After 20 min, doses of trazodone (10(-9) M vs 10(-3) M) were given cumulatively. The resulting effects were recorded. Results: The groups were compared within themselves: a significant difference was found between the initial tensions in the group with ACh-induced contractions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-7), 10(-6) , 10(-5), 10(-4), and 10(-3) M doses (p<0.0001). In the group with spontaneous contractions, a significant difference was found between the initial tensions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-5), and 10(-4) M doses (p<0.0001). Conclusion: Results showed that trazodone had a significant inhibitory effect on bladder smooth muscle contractions in vitro, especially at concentrations of 10(-4) and 10(-3) M.Öğe Investigation of the effect of trazodone on spontaneous and acetylcholine-induced bladder detrusor smooth muscle contractions(Kare Publ, 2022) Burunsuz, Ozge; Ozdengul, Faik; Gica, Sakir; Sen, Aysu; Sahin, ZaferObjective: The management of psychiatric patients is often complicated by medical comorbidities, complex pharmacological regimens, and side effects secondary to these regimens. In the current study, it was aimed to investigate the effects and mechanism of action of trazodone on rat bladder smooth muscle contractility in vitro. Method: Sixteen adult male Wistar albino rats were euthanized by the cervical dislocation method following ether anesthesia. Two muscle strips of 2x10 mm in size were prepared vertically from the bladder by opening a longitudinal incision from the neck of the bladder in the direction of the apex. The strips were tied properly and hung in the organ bath. All contraction amplitudes and frequencies were recorded. After a 45-min adaptation period, contractions were induced by applying 10(-5) M acetylcholine (ACh) to all spontaneously contracting bladder strips. After 20 min, doses of trazodone (10(-9) M vs 10(-3) M) were given cumulatively. The resulting effects were recorded. Results: The groups were compared within themselves: a significant difference was found between the initial tensions in the group with ACh-induced contractions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-7), 10(-6) , 10(-5), 10(-4), and 10(-3) M doses (p<0.0001). In the group with spontaneous contractions, a significant difference was found between the initial tensions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-5), and 10(-4) M doses (p<0.0001). Conclusion: Results showed that trazodone had a significant inhibitory effect on bladder smooth muscle contractions in vitro, especially at concentrations of 10(-4) and 10(-3) M.
