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    Appendix Vermiformis Morphology in the Adult Age Group: What we've learned from more than 250 Patients on Computer Tomography
    (Gazi Univ, Fac Med, 2021) Ozer, Halil; Yazol, Merve; Senturk, Mustafa
    Objective: This article assesses normal appendix vermiformis morphology in the adult age group by computed tomography (CT). Material and Methods: A total amount of 256 cases who had a clinical suspicion of urolithiasis and underwent abdominal-pelvic non-enhanced CT were enrolled in the study. Appendiceal diameter, wall thickness, intraluminal content, and the presence of an appendicolith were evaluated. Variables summarized by descriptive statistics. Groups were compared using the chi-square test and student t-test. Results: The mean diameter of the appendix was 6.5 +/- 1.2 mm (range, 3.1-9.7 mm) in all cases. Intraluminal air content detected in 199 (77.7%) cases. In 57 (22.3%) cases without air within the lumen, the appendix was evaluated as collapsed or isodense. Mean appendix diameter was 6.7 +/- 1.1 mm in cases with air in the lumen and the mean appendix diameter was 5.8 +/- 1.3 mm in cases with isodense or collapsed appearances (p < 0.001). Mean wall thickness of appendix determined as 1.7 +/- 0.3 mm (range, 0.9-3.1 mm). Appendicolith was detected in seven (2.7%) cases. Conclusion: In the presence of air in the appendiceal lumen, the increase in diameter can be interpreted normal unless not accompanied by inflammatory findings. It should be kept in mind that normal appendix diameter may be 6 mm or above when the intraluminal content of the appendix could not be distinguished.
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    Appendix Vermiformis Morphology in the Adult Age Group: What we've learned from more than 250 Patients on Computer Tomography
    (Gazi Univ, Fac Med, 2021) Ozer, Halil; Yazol, Merve; Senturk, Mustafa
    Objective: This article assesses normal appendix vermiformis morphology in the adult age group by computed tomography (CT). Material and Methods: A total amount of 256 cases who had a clinical suspicion of urolithiasis and underwent abdominal-pelvic non-enhanced CT were enrolled in the study. Appendiceal diameter, wall thickness, intraluminal content, and the presence of an appendicolith were evaluated. Variables summarized by descriptive statistics. Groups were compared using the chi-square test and student t-test. Results: The mean diameter of the appendix was 6.5 +/- 1.2 mm (range, 3.1-9.7 mm) in all cases. Intraluminal air content detected in 199 (77.7%) cases. In 57 (22.3%) cases without air within the lumen, the appendix was evaluated as collapsed or isodense. Mean appendix diameter was 6.7 +/- 1.1 mm in cases with air in the lumen and the mean appendix diameter was 5.8 +/- 1.3 mm in cases with isodense or collapsed appearances (p < 0.001). Mean wall thickness of appendix determined as 1.7 +/- 0.3 mm (range, 0.9-3.1 mm). Appendicolith was detected in seven (2.7%) cases. Conclusion: In the presence of air in the appendiceal lumen, the increase in diameter can be interpreted normal unless not accompanied by inflammatory findings. It should be kept in mind that normal appendix diameter may be 6 mm or above when the intraluminal content of the appendix could not be distinguished.
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    Computed Tomography Analysis of Nasal Anatomy in Dorsal Preservation Rhinoplasty
    (Oxford Univ Press Inc, 2022) Eravci, Fakih Cihat; Ozer, Halil; Arbag, Hamdi; Eryilmaz, Mehmet Akif; Aricigil, Mitat; Dundar, Mehmet Akif
    Background Subdorsal septal resection and radix osteotomy are distinctive surgical steps in preservation rhinoplasty. Objectives The aim of this study was to evaluate the nasal bone thickness, the level of the septal bony-cartilaginous junction (K area), and the distances of the frontal sinus and skull base from the transverse osteotomy line in the Turkish population by means of conventional computed tomography (CT). Methods A retrospective evaluation was made of 203 consecutive preoperative paranasal CT scans of patients (classified in terms of age and gender) who had undergone rhinoplasty surgery between January 2020 and June 2021. The nasal bone thickness at the medial canthus level, and the distances between the transverse osteotomy line and the K area, the frontal sinus, and the cribriform plate were measured. Results The mean measurements were similar in terms of age groups (P = 0.402, P = 0.542, P = 0.134 and P = 0.276 for ages 18-30, 30-40, 40-50, and >50 years, respectively). The mean nasal bone thickness and the distance between the transverse osteotomy line and the K area showed statistical significance (P = 0.001 and P = 0.001, respectively). In both genders, the mean distances between the transverse osteotomy line and the frontal sinus and the cribriform plate were similar (P = 0.921 and P = 0.280, respectively). The nasal bone was thinner and the K area position more cephalic in females. Conclusions CT plays an important role in preoperative planning. The need for resection of the ethmoid perpendicular bone may be greater in males when lowering the dorsal hump, and hence they may be more prone to skull base complications. It is therefore necessary to be more careful in the surgical stage of subdorsal septal excision in males.
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    Effects of Tumor Volume on Lymph Node Involvement and Prognosis at Stage pt3 Colon Cancers
    (Springer India, 2022) Senturk, Mustafa; Ozer, Halil; Celik, Abdulkadir; Yildirim, Mehmet Aykut; Cakir, Murat; Vatansev, Celalettin
    Some studies showed that the increase of tumor size has a negative effect on survival in colon cancers. Our study aims to assess the effects of tumor volume on lymph node positivity and prognosis in stage pT3 colon cancers. All patients who underwent surgery for colon cancer in our clinic were evaluated retrospectively. The study included 213 patients who were diagnosed with colon adenocarcinoma and reported as pathologic. Preoperative abdomen computed tomography scans were used for measurements of tumor volume. Tumor volumes were compared according to the pathological lymph node involvement. Cut-off values were determined with ROC analysis. The cases were divided into groups according to the determined cut-off value and data compared. Mean tumor volume was found to be higher in the lymph node-positive group (p=0.01). The higher number of removed lymph nodes and lymph node positivity was detected more in cases that were above the cut-off value (p=0.003 and p=0.004, respectively). The mean survival time was 37.3 +/- 1.3 months. There was no correlation between tumor volume and the overall survival time (p=0.21). According to data comparison of the lymph node positivity, Kaplan-Meier analysis showed that the increase of the N stage reduces the 5-year survival rate (for the N0, N1, N2 stages, 60%, 52%, 35%, respectively). Tumor volume is correlated with lymph node involvement. It has been shown that increasing the N stage has a negative effect on prognosis. Our study showed that tumor volume has no significant impact on survival but may have an indirect effect on prognosis.
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    Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients
    (Springer London Ltd, 2021) Tezcan, Dilek; Sivrikaya, Abdullah; Ergun, Dilek; Ozer, Halil; Eryavuz Onmaz, Duygu; Korez, Muslu Kazim; Akdag, Turan
    Objective: Interstitial lung disease (ILD) is one of the most severe complications which is associated with connective tissue disease (CTD) and causes to morbidity and mortality. So, we aimed to determine serum levels of interleukin-6 (IL-6), IL-13, and IL-17, to investigate whether these cytokines are related to CTD-ILD, and to find their possible contribution to determining the prognosis of the disease. Methods: A total of 150 participants, 80 patients diagnosed with CTD-ILD (mean age, 58.21 +/- 12.36) and 70 healthy controls (mean age, 57.07 +/- 9.60) were recruited from the rheumatology department between January 2016 and June 2019 in the study. High-resolution computed tomography (HRCT) findings were scored as similarly to previous studies. Serum IL-6, IL 13, and IL-17 levels were measured by ELISA test kits. Results: The levels of IL-6, IL-13, and IL-17 in CTD patients were significantly higher than the healthy individuals (p < 001), but the HRCT score's relation were not determined. IL-6 was associated with disease duration and disease activity scores of DAS28, ESDAII, and dSSc. There was a significant relation between dSSc, HCRT fibrosis, and total score. CRP, hemoglobin, and platelets were associated with the HRCT inflammation pattern. Conclusion: At the study, it has been observed that serum IL-13, IL-6 and IL-17 levels are increased in patients with CTD-ILD. Besides, IL-6 was associated with disease activity scores of DAS28, ESDAII, and dSSc. Also, HRCT fibrosis score is associated with dSSc. Further and comprehensive studies are needed to understand better the complex intersection of lung disease with systemic autoimmunity.
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    Texture analysis of multiparametric magnetic resonance imaging for differentiating clinically significant prostate cancer in the peripheral zone
    (Tubitak Scientific & Technological Research Council Turkey, 2023) Ozer, Halil; Koplay, Mustafa; Baytok, Ahmet; Seher, Nusret; Demir, Lutfi Saltuk; Kilincer, Abidin; Kaynar, Mehmet
    Background/aim: Texture analysis (TA) provides additional tissue heterogeneity data that may assist in differentiating peripheral zone (PZ) lesions in multiparametric magnetic resonance imaging (mpMRI). This study investigates the role of magnetic resonance imaging texture analysis (MRTA) in detecting clinically significant prostate cancer (csPCa) in the PZ.Materials and methods: This retrospective study included 80 consecutive patients who had an mpMRI and a prostate biopsy for sus-pected prostate cancer. Two radiologists in consensus interpreted mpMRI and performed texture analysis based on their histopathology. The first-, second-, and higher-order texture parameters were extracted from mpMRI and were compared between groups. Univariate and multivariate logistic regression analyses were performed using the texture parameters to determine the independent predictors of csPCa. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic performance of the texture parameters.Results: In the periferal zone, 39 men had csPCa, while 41 had benign lesions or clinically insignificant prostate cancer (cisPCa). The majority of texture parameters showed statistically significant differences between the groups. Univariate ROC analysis showed that the ADC mean and ADC median were the best variables in differentiating csPCa (p < 0.001). The first-order logistic regression model (mean + entropy) based on the ADC maps had a higher AUC value (0.996; 95% CI: 0.989-1) than other texture-based logistic regres-sion models (p < 0.001).Conclusion: MRTA is useful in differentiating csPCa from other lesions in the PZ. Consequently, the first-order multivariate regression model based on ADC maps had the highest diagnostic performance in differentiating csPCa.