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    Diagnostic and Prognostic Significance of Neutrophil Gelatinase-Associated Lipocalin and Pentraxin-3 in Acute Coronary Syndrome
    (Galenos Publ House, 2017) Ozer, Muhammet Rasit; Ergin, Mehmet; Kilinc, Ibrahim; Dundar, Zerrin Defne; Ozer, Nejla; Onal, Mehmet Akif; Girisgin, Abdullah Sadik
    Aim: The aim was to evaluate the levels of serum pentraxin-3 (PTX-3) and neutrophil gelatinase-associated lipocalin (NGAL) and the efficiency of making a diagnosis and to estimate the prognosis in patients with chest pain. Materials and Methods: The study was conducted in the Necmettin Erbakan University Meram Medicine School Emergency Department. Patients who had chest pain and met the inclusion criteria were accepted. They were divided into the following groups: acute coronary syndrome (ACS), a diagnosis other than ACS (non-ACS), and control. The patients in theACS and non-ACS groups were divided into five sub-group - groups: ST Elevated Myocardial Infarction (STEMI) Non-ST Elevated Myocardial Infarction (NSTEMI), Unstable Angina Pectoris (USAP), stable angina, and pulmonary embolus. For all patients, serum PTX-3, serum NGAL, troponin I, and creatine kinase-MB fraction (CK-MB) levels were measured. Results: There were 199 patients in the ACS and non-ACS groups and 30 patientsin the control group. There was no significant difference among the study groups in terms of age and PTX-3 and NGAL levels. When comparing survival and non-survival in terms of in-hospital death, CK-MB and troponin I levels were significantly higher in the ACS and non-ACS groups than in the control groups, whereas there was no significant difference in terms of PTX-3 and NGAL levels. Conclusion: The results of our study demonstrated that PTX-3 and NGAL are not effective biomarkers in the differential diagnosis and the determination of in-hospital mortality in ACS. However, the limitations of the study should be considered. The results confirmed that CK-MB and Troponin I can be safely used in the differential diagnosis and the prediction of mortality.
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    The Impact of Body Mass Index Values on the Quality of Cardiopulmonary Resuscitation: A Manikin Study
    (Marmara Univ, Inst Health Sciences, 2021) Kucukceran, Kadir; Ayranci, Mustafa Kursat; Ozer, Muhammet Rasit
    Objective: The purpose of this study is to assess the impact of body mass index (BMI) on the quality of cardiopulmonary resuscitation (CPR) by using a manikin. Methods: 50 people composed of research assistants, intern doctors, emergency medical technicians and nurses who had previous cardiopulmonary resuscitation experience performed CPR on Laerdal Skillmeter Resusci-Anne (R) with SimPad manikin during the study. BMI data of participants were recorded and then the participanst were categorised as BMI <21 and BMI >21. Compression data obtained from the summary section of SimPAD QCPR were compared with the participants BMI values. Results: 18 (36%) out of 50 participants were male, while 32 (64%) were female. 16 (32%) out of 50 participants were in the slim group, while 34 (68%) were in the normal group. Mean age of participants was calculated as 26.8 +/- 4.2, and mean BMI as 22.56 +/- 3.32. Mean compression depth in the slim group was significantly lower in comparison to the normal group (slim51.94 +/- 4.64, normal 55.79 +/- 4.35, p=0.006). Compression ratiowith sufficient depth in the slim group was statistically lower than the normal group (slim 66.19 +/- 25.79, normal 87.29 +/- 19.36, p=0.002). A statistically significant positive correlation was found in the lineer regression analysis conducted between mean compression depth and BMI (r2:0.179, p=0.002). Moreover, a significant positive correlation was observed in the pearson correlation analysis of mean compression depth and BMI (r: 0.423, p=0.002). Conclusion: As a result, it was found out that low BMI values are associated with low mean compression depth.
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    Roles of CRP and Neutrophil-to-Lymphocyte Ratio in the Prediction of Readmission of COVID-19 Patients Discharged From the ED
    (Taiwan Soc Emergency Medicine, 2022) Avci, Ali; Ozer, Muhammet Rasit; Kucukceran, Kadir; Yurdakul, Mehmet Serkan
    Background: Patient admissions beyond the capacity of emergency departments (EDs) have been reported since the coronavirus disease (COVID-19) pandemic. Thus, laboratory parameters to predict the readmission of patients discharged from the ED are needed. For this purpose, we investigated whether C-reactive protein (CRP) level and neutrophil-to-lymphocyte ratio (NLR) could predict the readmission of patients with COVID-19. Methods: Patients aged >18 years who visited the ED in October 2020 and had positive polymerase chain reaction test results were evaluated. Among these patients, those who were not hospitalized and were discharged from the ED on the same day were included in the study. The patients' readmission status within 14 days after discharge, age, sex, complaint on admission, comorbidity, systolic blood pressure, diastolic blood pressure, fever, pulse, oxygen saturation level, CRP level, blood urea nitrogen level, creatinine level, neutrophil count, lymphocyte count, and NLR were recorded. Data were compared between the groups. Results: Of the 779 patients who were included in the study, 359 (46.1%) were male. The median age was 41 years (range, 31-53 years). Among these patients, those who were not hospitalized and were discharged from the ED on logistic regression analysis, age, CRP level, NLR, loss of smell and taste, and hypertension had odds ratios of 2.494, 2.207, 1.803, 0.341, and 1.879, respectively. Conclusions: The strongest independent predictor of readmission within 14 days after same-day ED discharge was age > 50 years. In addition, CRP level and NLR were the laboratory parameters identifi ed as independent predictors of ED readmission.