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    Assessment of ELR, NLR, MPV, and CRP Levels in Patients With Acne Vulgaris
    (Galenos Publ House, 2022) Daye, Munise; Temiz, Selami Aykut; Ozturk, Elif Nur Yildirim; Isik, Begum
    BACKGROUND/AIMS: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. The relationship between some of the hematological parameters active in inflammation such as the neutrophil/lymphocyte ratio (NLR), the mean platelet volume (MPV), and C-reactive protein (CRP) has been demonstrated. In recent years, eosinophil cells have been shown to be associated with inflammation, and the eosinophil/lymphocyte ratio (ELR) has been shown to be an indicator of inflammation in some diseases. In this study, we aimed to evaluate the relationship between the ELR, NLR, MPV, and CRP levels, which are indicators of systemic inflammation, with acne severity parameters in patients with acne vulgaris. MATERIALS AND METHODS: A prospective study was planned with patients in our clinic who were diagnosed with acne vulgaris, who required routine blood parameters, and whose global acne score was calculated. The relationship between these parameters, which are an indicator of systemic inflammation and acne severity, was investigated. RESULTS: In our findings, MPV was found to be the strongest hematological marker for acne severity and inflammation. There was a significant difference between acne severity and ELR, and this difference was higher in the severe acne group. CONCLUSION: As far as we are aware, there has been no study on ELR levels in acne to date; this is the first study to evaluate this rate. Based on our findings, it is thought that ELR increases with the severity of acne and can be accepted as an indicator. In this context, we believe that there is a need for controlled studies involving the role of eosinophils in blood, tissue, and inflammation in the pathogenesis of acne. It is possible that the role of eosinophils in pathogenesis will explain itch-dominated acne patients and may also lead to the development of new targets for treatment.
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    Comparison of the Efficacy of Three Natural Surfactants in Preterm Turkish Newborns with Respiratory Distress Syndrome
    (Galenos Yayincilik, 2021) Yilmaz, Fatma Hilal; Tarakci, Nuriye; Gultekin, Nazli Dilay; Yucel, Mehmet; Kececi, Ramazan; Ozturk, Elif Nur Yildirim; Altunhan, Huseyin
    Aim: To determine the efficacy of three natural surfactant preparations in our community and the short- and long-term results of these on preterm infants. Materials and Methods: This was a retrospective research on 193 premature babies with respiratory distress syndrome (RDS). The patients were divided into three groups, each of which received one of three surfactants: Group 1; beractant (100 mg/kg); group 2; poractant alfa (first dose of 200 mg/kg, recurrent doses of 100 mg/kg); group 3; calfactant (100 mg/kg). The groups were compared according to demographic characteristics, 1- and 5-minute Apgar scores, weight percentiles by gestational week, presence of pulmonary hemorrhage, surfactant dose repetition, air leak, bronchopulmonary dysplasia (BPD), stage of intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), hemodynamically significantpatent ductus arteriosus (hs-PDA) and its medical or surgical treatment, retinopathy of premature (ROP) and its treatment, sepsis, ventilation time (both non-invasive and invasive), free oxygen need time, time to start full enteral feeding, discharge time, and mortality. Results: A total of 193 preterm infants with a mean gestational age of 28.9 +/- 3.1 weeks and mean birth weight of 1,190.4 +/- 504.3 grams were included in this study. The neonates were allocated into three different groups randomly, namely group-1 (n=77), group-2 (n=59), and group-3 (n=57). There were no differences in the clinical and demographic features of the groups. The incidence of pulmonary hemorrhage, surfactant dose repetition, air leak, ventilation time for both non-invasive and invasive, free oxygen need time, hs-PDA and surgical treatment of PDA, BPD, NEC (>= stage II), IVH (>stage III), ROP, time to start full enteral feeding, and discharge time were similar between the study groups. The sepsis and mortality rates were lower in group 3 compared to groups 1 and 2 (p=0.015, p=0.001). Conclusion: In this study, beractant, proctant alfa and calfactant had clinically similar efficacy in patients with RDS.
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    Development of an Attitude Scale for Cancer Screening
    (Kare Publ, 2020) Ozturk, Elif Nur Yildirim; Uyar, Mehmet; Sahin, Tahir Kemal
    OBJECTIVE This study aims to develop a scale to measure people's attitudes towards cancer screening and conduct a pilot study and validity-reliability study of the developed scale. METHODS This methodological study was conducted on 334 voluntary male and female relatives of patient who were between 30-70 years of age and attend family health centers at Meram district of Konya province. A sociodemographic form and a candidate scale were used for data collection. Data analysis was performed in a computer setting. RESULTS The study group of 334 participants consisted of 50% males and 50% females, and the mean age was 42.93 +/- 9.60 years. Four items with item score-scale score correlation less than +/- 0.200 were excluded from the 28-item candidate scale. Cronbach's alpha coefficient of the 24-item scale was calculated as 0.95. Face and content validity of the scale was evaluated with two different groups. Factor analysis that was used to assess the construct validity of the one-dimensional 24-item scale determined that explained the variance ratio was 52.62%. CONCLUSION As a result of our study, a new five-point Likert scale called Attitude Scale for Cancer Screening has been developed. Validity and reliability studies of the scale suggest that the scale is suitable for use in our society.
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    Foetal umbilical cord brain-derived neurotrophic factor (BDNF) levels in pregnancy with gestational diabetes mellitus
    (Taylor & Francis Inc, 2022) Bayman, Melike Geyik; Inal, Zeynep Ozturk; Hayiroglu, Fatih; Ozturk, Elif Nur Yildirim; Gezginc, Kazim
    The aim of our study was to investigate whether gestational diabetes mellitus (GDM) affects brain-derived neurotrophic factor (BDNF) levels in foetal umbilical cord blood. A total of 96 participants were divided into a GDM group (n = 43) and a non-diabetic control group (n = 53). Cord blood samples of approximately 5 cc were taken immediately after the foetal umbilical cord was clamped during delivery in order to determine BDNF levels. While the mean age, body mass index, birth weight, rate of caesarean delivery, rate of infant macrosomia, and neonatal intensive care unit admission of women with GDM were significantly higher compared to the non-diabetic control group (p < .05), pregnancy complications were comparable between the groups (p > .05). Although no significant differences were noted between the groups with respect to cord blood BDNF levels (0.79 +/- 0.37 ng/ml vs. 0.69 +/- 017 ng/ml, p = .122), cord blood BDNF values were higher in female infants compared to male infants (0.85 +/- 0.33 ng/ml vs. 0.66 +/- 0.23 ng/ml, p = .001) and in patients using insulin compared to those not using insulin in the GDM group (0.78 +/- 0.14 ng/ml vs. 0.62 +/- 0.09 ng/ml, p < .001). This study found that GDM has no effect on cord blood BDNF levels. More in-depth studies with larger series are needed to validate the results of the present study.Impact statement What is already known on this subject? Gestational diabetes mellitus (GDM) negatively affects the foetal neurodevelopment due to inflammation and oxidative stress caused by hyperglycaemia. Brain-derived neurotrophic factor (BDNF) expression has been shown to modulate oxidative stress and inflammation, and there may be a relationship between varying BDNF concentrations and GDM. What do the results of this study add? Our study showed that no significant differences were noted between the groups with respect to cord blood BDNF levels, cord blood BDNF values were higher in female infants compared to male infants, and in patients using insulin compared to those not using insulin in the GDM group. What are the implications of these findings for clinical practice and/or further research? GDM negatively affects the foetal neurodevelopment due to inflammation and oxidative stress caused by hyperglycaemia. BDNF expression has also been shown to modulate oxidative stress and inflammation, and there may be a relationship between varying BDNF concentrations and GDM. The association between BDNF expression and GDM has not been clearly elucidated in the literature. More in-depth studies with larger series are needed to determine this relationship.