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    Attention deficit hyperactivity disorder symptoms in children with vocal fold nodules
    (Elsevier Ireland Ltd, 2016) Erdur, Omer; Herguner, Arzu; Ozturk, Kayhan; Kibar, Ertugrul; Elsurer, Cagdas; Bozkurt, Mete Kaan; Herguner, Sabri
    Objectives: The aim of this case-control study was to investigate the symptoms of attention-deficit/hyperactivity disorder (ADHD) in children with vocal fold nodules (VNs). Methods: Study group (SG) included children between 4 and 12 years. As a control group (CG), children between 4 and 12 years without VNs were included in the study. Parents of the participants completed the Conners' Parent Rating Scale-Revised: Short Form (CPRS-RS) which was used to analyze the symptoms of ADHD. Results: Forty-five children (30 boys and 15 girls) with VNs and 45 controls (30 boys and 15 girls) were enrolled in the study. Multivariate analysis of variance revealed that the CPRS-RS Hyperactivity and Oppositional Subscales were significantly higher in the SG than the CG (p < .05), after controlling the effects of age and gender. Conclusions: Our findings suggest associations between VNs and hyperactivity and oppositional behaviors in children. Clinicians should be aware of ADHD symptoms in children with VNs. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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    Clinical and Polysomnographic Properties of Patients with Positional Obstructive Sleep Apnea Syndrome
    (Aves, 2012) Yosunkaya, Sebnem; Ozturk, Kayhan
    Aim: Positional patients (PP) were patients with obstructive sleep apnea (OSA) whose apnea hypopnea index (AHI) becomes at least twice as high in the supine position as in the lateral position and an AHI that normalizes (AHI<5) in the non-supine position. Non-positional patients (NPP) were characterised by an AHI in the supine position less than twice as high as in the lateral position. In this study we aimed to compare clinical, polysomnographic and physical characteristics of patients with non-positional and positional sleep apnea. Materials and Methods: Medical records of 500 patients diagnosed with OSA syndrome (OSAS) by polysomnography (PSG) in our clinic, between 2006-2008, were retrospectively reviewed, and 230 of these were included in the study. Patients were separated into two groups according to polisomnographic results as PP and NPP. The clinical, polysomnographic and physical characteristics of the two groups were compared. Results: 112 of the 230 patients (48.6%) were classified as PP. These were younger, with lower body mass index and neck circumflex and a milder OSAS as compared to the NPP. AHI in 31% of the PP fell below 5 in the lateral recumbent position. Excessive daytime sleepiness (EDS), as assessed by the Epworth Sleepiness Scale, was lighter in the PP group. Also, frequency of complaint from year-long nasal blockage and frequency of finding turbinate hypertrophy were more common in the PP as compared to the NPP. Conclusion: In this study, basic features of patients diagnosed as positional OSAS over a two-year period were documented by grouping as PP and NPP. Some differences were identified at the physical examination, clinical and polysomnographic features of the positional and non-positional cases.
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    Histopathological Evaluation of Platelet-Rich Plasma Effect in Acute Tympanic Membrane Perforation
    (Springer India, 2022) Cobden, Serap Bulut; Ozturk, Kayhan; Duman, Selcuk; Esen, Hasan; Aktan, Tahsin Murad; Avunduk, Mustafa Cihat; Elsurer, Cagdas
    Platelet-rich plasma (PRP) is a reliable and has low side-effect profile and has beneficial effects on wound healing. Its investigatory effects on wound-healing process were shown on various tissues. This study aims to investigate PRP's local application effects to perforated rat TM in terms of healing and histopatological outcomes. Twenty-two Wistar rats were used in the study. The rats' ears were examined with a pediatric endoscope (2.7 mm, 0 degrees), and the TM posterior quadrant of their right ear was perforated with a 20-gauge needle. After this procedure, the rats were divided into two equal groups. A spongel with PRP was applied on the perforated TM in the first group, and spongel with standard saline solution was applied on the second group. Following the sacrifice, the middle air bullas were carefully dissected and removed for histopathological examination. Hematoxylin eosin (for fibroblasts, lymphocyte, collagen fibers) and immunohistochemical staining were done for epithelial growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR1), and vascular endothelial growth factor (VEGF) staining for histopathologic examinations. There was not a significant difference between the two groups for lymphocyte. There was a significant difference between control and study groups for collagen and EGFR (P < 0.05). Although the mean value of FGF- and VEGF-positive cells was higher in the study group than in the control group, the difference was not significant (P > 0.05). PRP is an effective autologous material for the healing process of acute TM perforations in a rat model, as demonstrated in the present study. We think that the use of PRP for acute TM perforations can have a positive effect on the healing process by increasing the level of growth factors, especially EGFR. In addition, an increase in collagen can also have a positive effect on healing.
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    Selection of reliable reference genes for qRT-PCR analysis on head and neck squamous cell carcinomas.
    (Scientific Publishers India, 2017) Yigin, Aysel Kalayci; Cora, Tulin; Acar, Hasan; Kurar, Ercan; Kayis, Seyit Ali; Colpan, Bahar; Ozturk, Kayhan
    The choice of reliable reference genes as an internal control is inevitable to obtain accurate results. Here we present an assessment of 7 reference genes (18S rRNA, 28S rRNA, ACTB, GAPDH, TUBA1, YWHAZ, and SDHA) to normalize gene expression data in Head and Neck Squamous Cell Carcinomas (HNSCCs). We attempted to determine a reliable set of reference genes to use in the normalization of gene expression data in Head and Neck Squamous Cell Carcinomas (HNSCCs) and normal mucosal tissues. Malignant and non-malignant tissue samples were collected from 12 patients with primary untreated HNSCC. geNorm and NormFinder software packages were used for data evaluations. Results obtained by geNorm indicated that average expression stability values (M) of all candidates genes were smaller than 1.5 (accepted M value for geNorm), showing that all the evaluated genes can be employed as HKGs, although GAPDH and ACTB were reported to be the most stable. Similarly, NormFinder results were in agreement with geNorm's results. GAPDH and ACTB are considered to be most suitable reference genes to evaluate novel gene expression in the tissues several of HNSCCs.
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    Treatment of Acute Vocal Fold Injury With Platelet-Rich Plasma
    (Mosby-Elsevier, 2016) Cobden, Serap Bulut; Ozturk, Kayhan; Duman, Selcuk; Esen, Hasan; Aktan, Tahsin Murad; Avunduk, Mustafa Cihat; Elsurer, Cagdas
    Objectives. Platelet-rich plasma (PRP) is a reliable and has low side-effect profile and has beneficial effects on wound healing. Its investigatory effects on wound-healing process were shown on various tissues. The aim of the present study was to evaluate effectiveness of PRP application on scar tissue of acute vocal fold injury. Materials andmethods. Twenty-fourWistar rats were used in the study. The entire layer of the lamina propria down to the thyroarytenoid muscle of 10 subjects was unilaterally injured by with a microscissor. Gelfoam-absorbed PRP was applied on the injured area for 10 minutes. Control group consisted of rats unilaterally injured using a microscissor, and gelfoam with normal saline was applied on the injured area. Following sacrifice, the larynxes were carefully dissected and removed for histopathologic examination. After excised larynx experiments, serial sections were prepared from vocal fold. Hematoxylin eosin and immunohistochemical staining were done for epithelial growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR1), and vascular endothelial growth factor (VEGF) staining for histopathologic examinations. Results. There was not a significant difference between the two groups for lymphocyte. Although collagen and VEGF were higher in the study group, there was not a significant difference between the groups (P > 0.05). There was a significant difference between control and study groups for EGFR and FGFR1(P < 0.05). Conclusions. PRP has beneficial effects on wound healing. PRP accelerates epithelization of injured rat vocal folds by inducing EGFR secretion. PRP is an autogenous, reliable, low side-effect profile, easily harvested material. PRP may be useful to prevent scar formation.