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Öğe Anemia Is A Crucial Finding In Childhood Idiopathic Pulmonary Hemosiderosis(Amer Thoracic Soc, 2014) Cinel, G.; Kiper, N.; Orhan, D.; Pekcan, S.; Yalcin, E.; Dogru, D.; Ozcelik, U.[Abstract Not Availabe]Öğe Barriers to Timely Diagnosis of Cystic Fibrosis Via Newborn Screening in Turkey(Amer Thoracic Soc, 2019) Gokdemir, Y.; Emiralioglu, N.; Sismanlar, T.; Er, B.; Pekcan, S.; Ergenekon, A.; Sen, V.[Abstract Not Availabe]Öğe Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans(European Respiratory Soc Journals Ltd, 2022) Eyuboglu, T. Sismanlar; Aslan, A. T.; Ramesli, T.; Pekcan, S.; Kose, M.; Hangul, M.; Aral, L. A.[Abstract Not Availabe]Öğe Cytomegalovirus infection in immunocompetent wheezy infants: the diagnostic value of CMV PCR in bronchoalveolar lavage fluid(Wiley, 2014) Cinel, G.; Pekcan, S.; Ozcelik, U.; Alp, A.; Yalcin, E.; Ersoz, D. Dogru; Kiper, N.What is known and objective: Cytomegalovirus (CMV) pneumonitis in immunocompetent hosts is uncommon but is being recognized more frequently, particularly when presenting as severe viral pneumonia. The objective of this study was to examine lower respiratory tract CMV infection in immunocompetent wheezy infants, based on polymerase chain reaction (PCR) in bronchoalveolar lavage (BAL) fluid, to compare CMV PCR results in BAL and in blood samples and to evaluate the benefits of antiviral ganciclovir therapy in these patients. Methods: Retrospective review of the records of patients referred to our tertiary care hospital between January 2000 and July 2010 who had unexplained persistent wheezing and underwent fibreoptic flexible bronchoscopy (FFB). Results and discussion: Fibreoptic flexible bronchoscopy was applied to 102 infants with persistent wheezing and diffuse interstitial infiltration on radiological investigations; so CMV PCR in BAL fluid was performed. CMV PCR in BAL fluid was positive in 51 patients. Retrospectively, we had access to the files of 25 of these patients. The mean CMV PCR in BAL fluid was 334 840 copies/mL. Only eight patients had CMV PCR positivity in their blood samples (mean: 2026.3 copies/mL). There was not a relationship between BAL and blood CMV PCR values based on Spearman's correlation analysis (r = -0.008). Fourteen patients had severe respiratory symptoms and received ganciclovir therapy. Twelve of them fully recovered. What is new and conclusion: Bronchoalveolar lavage fluid CMV PCR was superior to blood CMV PCR in diagnosing lower respiratory tract infections caused by CMV in immunocompetent infants. Ganciclovir therapy may be effective in selected immunocompetent wheezy infants with CMV PCR positivity in BAL fluid.Öğe Does atopy affect the course of viral pneumonia?(Elsevier Espana Slu, 2018) Erdem, S. B.; Can, D.; Girit, S.; Catal, F.; Sen, V.; Pekcan, S.; Yuksel, H.Background: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia. Methods: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Patients were classified into two groups as mild-moderate and severe according to the course of pneumonia. Presence of atopy was evaluated with skin prick tests. Groups were compared to evaluate the risk factors associated with severe viral pneumonia. Results: A total of 280 patients from nine centres were included in the study. Of these patients, 163 (58.2%) were male. Respiratory syncytial virus (29.7%), Influenza A (20.5%), rhinovirus (18.9%), adenovirus (10%), human metapneumovirus (8%), parainfluenza (5.2%), coronavirus (6%), and bocavirus (1.6%) were isolated from respiratory samples. Eighty-five (30.4%) children had severe pneumonia. Atopic sensitisation was found in 21.4% of the patients. Ever wheezing (RR: 1.6, 95% CI: 1.1-2.4), parental asthma (RR: 1.5, 95% CI: 1.1-2.2), other allergic diseases in the family (RR: 1.8, 95% CI: 1.2-2.9) and environmental tobacco smoke (RR: 1.6, 95% CI: 1.1-3.5) were more common in the severe pneumonia group. Conclusions: When patients with mild-moderate pneumonia were compared to patients with severe pneumonia, frequency of atopy was not different between the two groups. However, parental asthma, ever wheezing and environmental tobacco smoke exposure are risk factors for severe viral pneumonia in children. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Effect of Passive Smoking Exposure on Development of Childhood Pneumonia and Illness Severity.(Wiley, 2018) Eyuboglu, Sismanlar T.; Aslan, A. T.; Kose, M.; Pekcan, S.; Gulbahar, O.; Cingirt, M.; Demirdag, T. B.[Abstract Not Availabe]Öğe Evaluation of Children with Hydatid Cyst in the Middle Region of Turkey.(Wiley, 2017) Aslan, A. T.; Sismanlar, T.; Pekcan, S.[Abstract Not Availabe]Öğe EVALUATION OF CLINICAL, LABORATORY AND RADIO-LOGICAL FINDINGS IN HOSPITALIZED PATIENTS DIAGNOSED WITH LOWER RESPIRATORY TRACT INFECTIONS(Wiley-Blackwell, 2015) Pekcan, S.[Abstract Not Availabe]Öğe Follow-Up of Cystic Lung Diseases in our Center.(Wiley, 2018) Pekcan, S.; Buyukkaya, Z.; Dogan, Y.[Abstract Not Availabe]Öğe Immunodeficiency and Respiratory Papillomatosis Coexistence.(Wiley, 2018) Pekcan, S.; Buyukkaya, Z.[Abstract Not Availabe]Öğe New prognostic laboratory parameters and use of intravenous immunglobulin G replacement for severe H1N1 infections(Medimond S R L, 2013) Gokturk, B.; Pekcan, S.; Emiroglu, Keser M.; Kirac, M.; Keles, S.; Guner, Sn; Artac, H.The appropriate treatment of severe pandemic H1N1 influenza, which was first identified in April 2009 in Mexico, is insufficient, especially in immunodeficient patients. We aimed to evaluate the features and prognostic factors of children with H1N1, and whether intravenous immunoglobulin G (IVIG) replacement can aid in facilitating a better outcome. Fifty-five hospitalized children with laboratory-confirmed H1N1 were evaluated retrospectively. The median age was 71 (1-216) months; and 65.4% had one or more underlying disorders. Thirty percent of the evaluated patients had one of the primary immunodeficiency disorders. Respiratory complications were seen in 72.7% of children. The mortality rate was 9%. Surprisingly, none of the six patients with primary immunodeficiency who were on regular IVIG replacement required intensive care unit admission or died. Eighty-three percent of patients who needed mechanical ventilation (p<0.001) and 27.7% of patients who needed oxygen support (p=0.002) died. The mortality rate of patients who admitted with neurological symptoms was higher (p=0.012, odds ratio: 17.25, confidence interval: 2.19-135.4). The mortality rate was significantly higher in patients with thrombocyte counts <165500/mm(3) (sensitivity: 79.6%, specificity: 83.3%) and with alanine aminotransferase (ALT) levels >50.5 U/L (sensitivity: 83.3%, specificity: 89.8%). Our study is important as it is the first to show the course in primary immunodeficient children with H1N1 infection who were on regular IVIG replacement. Thrombocytopenia, high ALT, neurologic symptoms, and hypoxia were detected as poor prognostic factors.Öğe NEW PROGNOSTIC LABORATORY PARAMETERS AND USE OF INTRAVENOUS IMMUNOGLOBULIN G REPLACEMENT FOR SEVERE H1N1 INFECTIONS IN CHILDREN(Springer/Plenum Publishers, 2012) Gokturk, B.; Pekcan, S.; Emiroglu, M.; Guner, S. N.; Kirac, M.; Keles, S.; Artac, H.[Abstract Not Availabe]Öğe Sleep Habits and Related Factors in Kindergarten Children(Wolters Kluwer Medknow Publications, 2019) Durduran, Y.; Pekcan, S.; Colpan, B.Aim: This study aimed to determine the sleeping habits and sleeping periods of kindergarten children, in order to analyze the problems related to sleep hygiene and determine the underlying factors. Methods: The sample size of this cross-sectional study consisted of 390 children. A questionnaire filled in by the parents was used as the data collection tool. The data were analyzed with appropriate statistical tests. Results: According to the mothers, 77.2% of the children had their own room at home. Thirty nine percent of children slept with the full light on in their room, 50.3% slept with night light on in their room, 12.3% slept with the radio/television on in their room. Infant sleep practices found in this study are swaddling (18.5%), wrapping of the infant's arms (21.0%), and rocking (58.7%). Conclusions: In terms of sleep hygiene, the vast majority of the children slept in a bright environment, and there were electronic appliances in the room. Common infant-transition-to-sleep practices observed were wrapping their arms and swaddling them. In our point of view, awareness training for parents about the subject will support sleep hygiene practices.Öğe Treatment of Sialorrhea with Botulinum Toxin A Injection in Children(Wolters Kluwer Medknow Publications, 2021) Ture, E.; Yazar, A.; Dundar, M. A.; Bakdik, S.; Akin, F.; Pekcan, S.Aims: We aimed to evaluate the effectivity and safety of botulinum toxin A (BT-A) to reduce sialorrhea in children with hypersalivation due to neurological diseases. Methods: Patients who had a complaint of severe sialorrhea were included in the study. Drooling severity of the patients was evaluated using the classification of Thomas-Stonell and Greenberg. The frequency of aspiration before and after the procedure was recorded. The 24-hour saliva amount and mean duration of two consecutive aspirations were recorded. BT-A was injected into the bilateral parotid and submandibular glands by a otorhinolaryngologist under the guidance of ultrasound guidance (USG). Results: When patients' mean drooling severity scores, drooling frequency scores, mean duration of two consecutive aspirations, and amount of saliva collected before and after procedure were compared, a statistical significance was observed. One-year hospital records before after and injection were examined and it was observed that after BT-A injection, hospital visits were statistically significantly low (P = 0.017). Conclusion: BT-A injection into salivary glands is well tolerated, is minimally invasive, has low complication rates and should be performed into both parotid and submandibular glands under USG. Although there is still no consensus on the ideal dose and frequency of injections, it is thought that a dose of 1U/kg/gland can be used with safety in pediatric age groups and the dimensions of the salivary glands and quantitative measurements of the amount of saliva should be utilized. Larger studies involving more patients are required in order to constitute a standard injection protocol.
