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Öğe Effects of diclofenac sodium and octreotide on treatment of caerulein-induced acute pancreatitis in mice(E-Century Publishing Corp, 2015) Cakir, Ozlem Ozer; Esen, Hasan; Toker, Aysun; Ataseven, Huseyin; Demir, Ali; Polat, HakkiBackground: Research continues to develop novel therapeutic modalities that particularly focus on the pathogenesis of acute pancreatitis. This study aimed to assess the effects of diclofenac sodium and octreotide, alone or in combination, on pancreatic enzymes, pancreatic myeloperoxidase activity, histopathology and apoptosis of pancreas cells, using a model of experimentally induced acute pancreatitis. Objectives: We aimed to demonstrate effects of diclofenac sodium, octreotide and their combined use on pancreatic enzymes, activity of pancreatic myeloperoxidase (MPO) activity, histopathology and apoptosis of pancreas on treatment of caerulin-induced experimental acute pancreatitis. Materials and methods: Caerulin-induced acute pancreatitis model was created using a total of 58 male BALB-C mice of 25 gr in seven groups. Serum amylase, lipase levels and pancreatic myeloperoxidase activity were examined as well as apoptotic values in pancreatic acinar cells through TUNNEL method. Histopathology of pancreas was evaluated for presence of edema, hemorrhage, parenchymal necrosis, fat necrosis, leukocyte infiltration, and fibrosis. Results: In the diclofenac sodium group, apoptotic values in the pancreatic acinar cells were found to be statistically lower than in the acute pancreatitis group in terms of parenchymal necrosis and hemorrhage scores (P = 0.007, P = 0.002, and P = 0.052, respectively). No statistically significant differences were found in serum level of amylase, lipase, pancreatic myeloperoxidase activity and the other histopathological scores (P > 0.05). Conclusion: Diclofenac sodium, a cost-effective agent with a favorable side-effect profile, may represent a novel therapeutic agent for the treatment of acute pancreatitis. Findings of this study suggest a better efficacy for diclofenac sodium monotherapy as compared to octreotide alone or octreotide/diclofenac combination.Öğe The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis(Premchand Shantidevi Research Foundation, 2017) Cakir, Ozlem Ozer; Toker, Aysun; Ataseven, Huseyin; Demir, Ali; Polat, HakkiIntroduction: Acute hepatitis is acute inflammation of liver elicited by a large number of causes. It sometimes spontaneously recovers, sometimes may progress to chronic hepatitis. LiverFatty Acid Binding Protein (L-FABP) is a small protein that is abundant in hepatocytes, and which binds most of the longchain fatty acids present in the cytosol. Aim: The present study aimed to investigate the levels of serum and urine L-FABP in acute hepatitis and diagnostic value of serum and urine L-FABP levels in patients with acute hepatitis. Materials and Methods: The present study included a total of 85 patients. Total number of patients with acute hepatitis were 17 (five of acute hepatitis B, one of acute hepatitis A, two of acute hepatitis C, five of autoimmune hepatitis and four of toxic hepatitis), 19 of hepatic encephalopathy, 29 of liver cirrhosis, and 20 controls were included. Serum and urinary L-FABP levels were analyzed by the Enzyme-Linked Immunosorbent Assay (ELISA). Results: Serum L-FABP levels were 9110 +/- 3352.5, 9410 +/- 1355, 9715 +/- 2462 and 3672 +/- 982.5 ng/l in patients with acute hepatitis, hepatic encephalopathy and cirrhosis and control subjects, respectively. There were statistically significant positive correlations between serum levels of L-FABP and Aspartate Aminotransferases (AST), Alanine Aminotransferases (ALT), Creatinine (Cre) and Gamma Glutamyl Transferases (GGT) (p<0.001, p<0.001, p<0.001 and p<0.001, respectively). While the cut-off value of serum L-FABP for all of the patients was 5183 ng/ l {p<0.001 and Area Under Curve (AUC)0.985}, the sensitivity and specificity were 95.4% and 100%, respectively. Positive and negative predictive values for serum L- FABP were 100% and 87%, respectively. Conclusion: Serum and urine L-FABP may be a new diagnostic marker for liver damage in patients with acute hepatitis. However, our study showed that except of aminotransferases, L-FABP should be used for diagnosis of liver damage in patients with acute hepatitis, chronic hepatitis and also cirrhosis.Öğe Liver abscess after implantation of dental prosthesis(Baishideng Publishing Group Inc, 2012) Gungor, Gokhan; Biyik, Murat; Polat, Hakki; Ciray, Hilal; Ozbek, Orhan; Demir, AliPyogenic liver abscesses are rare but a life-threatening important condition. Dental procedures constitute only rare cases of pyogenic liver abscesses, with only a few cases in the literature. We report a patient with liver abscess following a dental procedure. A 74 years old diabetic male patient was admitted to our hospital with complaints of fatigue, 40 degrees C fever, rigors and right upper quadrant pain, 3-4 d after a dental procedure. Physical examination revealed fever and tenderness in the right upper quadrant. Laboratory examination revealed leucocytosis, elevated erythrocyte sedimentation rate and C-reactive protein and moderately elevated transaminases. An abscess was detected in radiological examination in the medial part of the left lobe of liver, neighboring the gall bladder. He was successfully treated with percutaneous abscess drainage and antibiotherapy. (C) 2012 Baishideng. All rights reserved.Öğe Obesity Is an Independent Determinant of Ischemia-Modified Albumin(Karger, 2012) Mehmetoglu, Idris; Kurban, Sevil; Yerlikaya, Fatma Humeyra; Polat, HakkiObjective: We have measured ischemia-modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS) and high-sensitivity C-reactive protein (hsCRP) levels in obese and normal-weight subjects to investigate if IMA can be used as a biomarker of oxidative stress and inflammation and if IMA was an independent determinant of obesity or not. Methods: The study was performed on 92 obese subjects (20 male, 72 female) aged 38 +/- 11 years and 78 normal-weight controls (19 male, 59 female) aged 37 +/- 11 years. Serum lipids, IMA, TAS, TOS, and hsCRP levels of the subjects were measured. Results: IMA (p < 0.05), TOS (p < 0.001), and hsCRP (p < 0.001) levels of the obese subjects were significantly higher, whereas TAS levels were significantly lower (p < 0.05) than those of the controls after adjustment for age and gender. In the linear regression analysis, waist circumference (r(2) = 0.139, p < 0.01), BMI (r(2) = 0.136, p < 0.01) and insulin (r(2) = 0.120, p < 0.05) were shown to be significant independent determinants of IMA levels. Conclusions: We have found that oxidative stress and inflammation were increased and antioxidative defense was decreased, which resulted in increased levels of IMA, a biomarker of ischemia, in obese subjects. Also, obesity and insulin were found to be independent determinants of IMA. Thus, obese subjects are under high risk of ischemia, and IMA may be used as a biomarker of oxidative stress and ischemia. Further larger investigations are needed to confirm this opinion. Copyright (C) 2012 S. Karger GmbH, FreiburgÖğe A polypoid mass in the common bile duct(Aves, 2016) Asil, Mehmet; Dertli, Ramazan; Biyik, Murat; Oltulu, Pembe; Ataseven, Huseyin; Polat, Hakki; Demir, Ali[Abstract Not Availabe]Öğe Predictive Ability of Liver Fatty Acid Binding Protein for All Cause Mortality in Patients With Hepatic Encephalopathy: A Prospective Observational Study(Nature Publishing Group, 2017) Cakir, Ozlem Ozer; Toker, Aysun; Ataseven, Huseyin; Demir, Ali; Polat, Hakki; Gungor, Gokhan; Biyik, Murat[Abstract Not Availabe]Öğe Predictive Ability of Liver Fatty Acid Binding Protein for All Cause Mortality in Patients With Hepatic Encephalopathy: A Prospective Observational Study(Nature Publishing Group, 2017) Cakir, Ozlem Ozer; Toker, Aysun; Ataseven, Huseyin; Demir, Ali; Polat, Hakki; Gungor, Gokhan; Biyik, Murat[Abstract Not Availabe]
