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Öğe 68Ga-PSMA PET/CT Uptake in Cutis Verticis Gyrata(Lippincott Williams & Wilkins, 2023) Sahin, Ozlem; Karakasoglu, Cennet Cansel; Erol, Caglagul; Daye, Munise[Abstract Not Availabe]Öğe Comparison of DMSA Scintigraphy and USG in Detecting Renal Cortical Scars in Children with Urinary Tract Infection(Georg Thieme Verlag Kg, 2018) Sahin, Ozlem; Tasbent, Fatma EsenkayaObjective Multiple imaging techniques may be used to evaluate the development of progressive renal damage in children with urinary tract infections (UTIs). The aim of this study was to compare the efficacy of Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy and renal ultrasonography (USG) in detecting renal scars in children with UTIs. Methods A total of 630 kidneys from 364 children were included in the study and the results of DMSA and USG of children with UTIs were evaluated retrospectively between January 2016 and October 2017. DMSA scintigraphy is accepted as the gold standard and it was compared with USG results. Results The sensitivity, specificity, positive predictive value, and negative predictive value for USG in the detection of renal scarring was found as 57.1, 89.6, 40.8, and 94.4%, respectively. Conclusions Although USG is known to be safe, readily available, and relatively inexpensive, the sensitivity of USG does not seem to be sufficient to identify the renal parenchymal damage. We concluded that USG cannot replace DMSA in the evaluation of renal scarring.Öğe COVID-19 Pneumonia Presenting with Multiple Nodules Mimicking Metastases: An Atypical Case(Ubiquity Press Ltd, 2022) Babaoglu, Seyma; Poyraz, Necdet; Sahin, OzlemCoronavirus disease 2019 (COVID-19) is an outbreak causing pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and computed tomography (CT) images are a significant part of the diagnosis of COVID-19 related pneumonia. Typical chest CT findings are bilateral peripheral ground-glass opacities (GGO) with or without consolidation. Although rare, atypical CT findings have been described, no case of COVID-19 causing multiple solid pulmonary nodules has been reported. In this article, atypical CT findings of a 45-year-old female patient with multiple solid pulmonary nodules mimicking metastasis diagnosed with COVID-19 confirmed by reverse transcription polymerase chain reaction (RT-PCR). Teaching point: COVID-19 pneumonia may mimic multiple metastatic nodules radiologically.Öğe Effect of R-CHOP chemotherapy on liver and mediastinal blood pool 18F-FDG standardized uptake values in patients with non-Hodgkin's lymphoma(Elsevier Science Inc, 2015) Kaya, Bugra; Dostbil, Zeki; Ismailoglu, Murat; Tasdemir, Bekir; Sahin, OzlemAim: We aimed to investigate the impact of chemotherapy on F-18-FDG uptake in the liver and mediastinal blood pool (MBP) among patients with non-Hodgkin's lymphoma. Methods: Twenty-three patients with NHL underwent baseline, interim, and postchemotherapy F-18-FDG PET/CT. SUVmax and SUVmean values of the liver and MBP at imaging time were compared statistically. Results: We did not find any significant differences between the liver and mediastinum SUVmean and SUVmax values (P>.05). Conclusions: Our study demonstrates that the F-18-FOG uptake in the liver and MBP are not significantly affected by R-CHOP chemotherapy in patients with NHL. (C) 2015 Elsevier Inc. All rights reserved.Öğe Erdheim-Chester disease diagnosed by 99mTc-MDP bone scintigraphy and brief literature review(Hellenic Soc Nuclear Medicine, 2018) Sahin, Ozlem; Oltulu, PembeErdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis with lipid-laden macrophages and fibrosis. Although ECD is a multisystemic disease, the most common finding is sclerotic bone involvement in the diametaphyseal regions of bilateral distal femur and in proximal and distal tibia. We present a 40 years old woman who for the last two years had various systemic symptoms, especially knee pain, polyuria and polydipsia. Although a hot knee pattern was seen in bone scintigraphy (BS), a femur biopsy was performed, due to the preliminary diagnosis of haematologic malignancy. The biopsy specimen showed only intense fibrosis. One year later while the patient was in our clinic, BS showed characteristic for ECD bone involvement. Bone biopsy specimens stained in hematoxylin and eosin showed dense fibrosis but not histiocytosis. However, after immunohistochemical staining with CD-68, histiocytes were discerned. In conclusion, the authors underline that ECD was diagnosed at a second diagnostic attempt both clinically and by specific staining pathology specimens.Öğe Hot Lung Sign in Pulmonary Intravascular Large B-Cell Lymphoma on 18F-FDG PET/CT(Lippincott Williams & Wilkins, 2020) Sahin, Ozlem; Kaya, Bugra; Serdengecti, Mustafa; Cizmecioglu, Hilal Akay; Sen, Ahmet ErenIntravascular large B-cell lymphoma is a rare type of non-Hodgkin lymphoma characterized by intravascular proliferation of clonal lymphocytes within the lumen of small vessels, which is often fatal. Diffuse FDG uptake in the lung without clear/evident CT findings, hot lung, is quasi-pathognomonic for lung intravascular large B-cell lymphoma. In this report, we present the case of a 43-year-old man who was diagnosed as having intravascular lymphoma thanks to this rare finding.Öğe Incidental Detection of Inguinoscrotal Bladder Hernia with Associated Factors on 18F-fluorodeoxyglucose PET/CT Scans(Coll Physicians & Surgeons Pakistan, 2022) Acar, Gulay; Sahin, OzlemObjective: To evaluate the associated factors of inguinoscrotal bladder hernia (ISBH), which was detected on F-18-fluorodeoxyglu-cose positron emission tomography/computed tomography (F-18-FDG PET/CT) scans. Study Design: An observational study. Place and Duration of Study: Department of Nuclear Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey, from August 2010 to April 2021. Methodology: In this study, 60 cases were subclassified in three age-matched groups; 15 patients diagnosed with ISBH in Group Ia, 15 cases with inguinoscrotal herniation (ISH) of bowel in Group Ib, and 30 patients without ISH in Group II. In the reconstructed PET/CT images, the prostate volume (PV), abdominal subcutaneous fat (SFV), and visceral fat (VFV) volumes were measured, and body mass index (BMI) was calculated. Results: There was a statistically significant relationship between subgroups of Group I in the measurements of BMI, PV, SFV, and VFV, which were higher in Group Ia than Group Ib. The lower SFV/VFV value in Group Ib was considered as the most important risk factor in developing ISH of the bowel. A significant statistical difference was found between Group I and II in terms of PV, VFV, and SFV/VFV parameters. Conclusions: This study reiterated the impact of PV and the parameters representing abdominal fat distribution on ISBH development. PET/CT scan provided valuable information regarding both the hernia contents and the associated factors in which the higher PV had a significant association for the development of ISBH as well as lower SFV/VFV that was more prominent in ISH with bowel.Öğe Late PET/CT Findings of COVID-19 Pneumonia With 2 Different Radiopharmaceuticals in a Patient PSMA Avidity Higher Than FDGs(Lippincott Williams & Wilkins, 2021) Sahin, Ozlem; Kaya, Bugra; Aydin, Zeynep; Karaagac, Mustafa; Kanyilmaz, GulWe present the Ga-68-PSMA and F-18-FDG PET/CT findings comparatively of a 67-year-old prostate cancer and malignant melanoma patient who had COVID-19 pneumonia 3 months ago. In Ga-68-PSMA PET/CT, ground-glass opacities showing markedly increased PSMA uptake were observed in the patient's lungs. It was learned that the patient had COVID-19 pneumonia 3 months ago and was treated in the intensive care unit for 13 days. In F-18-FDG PET/CT, FDG uptake was minimal in the same areas. In the midterm period after COVID-19 pneumonia, lung PSMA uptake is more intense than FDG, which may help better understand the disease's healing phase.Öğe Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary Report(Wiley, 2017) Kaptanoglu, Ece; Sahin, Ozlem; Tuncer, Tiraje; Hizmetli, Sami; Altan, Lale; Ayhan, Figen; Bal, Ajda[Abstract Not Availabe]Öğe Prostate incidentaloma on 18F-fluorodeoxyglucose positron emission tomography: Diagnostic value of volumetric positron emission tomography parameters(Georg Thieme Verlag Kg, 2021) Sahin, Ozlem; Kaya, Bugra; Aydin, Zeynep; Sen, Ahmet Eren; Iyisoy, Mehmet Sinan; Aydin, ArifObjective To evaluate whether volumetric PET parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) contributed to maximum standardized uptake value (SUVmax) in predicting prostate carcinoma in the prostate incidentalomas (PI) in 18F-FDG PET/CT. Materials and methods This retrospective study comprised 107 patients with PI of 4723 male patients who had undergone 18F-FDG PET/CT. SUVmax and volumetric PET parameters of PIs were assessed. MTV and TLG were acquired with each SUV threshold as 2.5, 3.0, 3.5, 4.0, 4.5, and 5.0. Results The PI incidence was 2.3 %, and the malignancy ratio of PI was 15.9 %. According to further analysis results, 17 patients were in the malignant group, and 46 patients were in the benign group. Malignant PIs had higher SUVmax (10.6 vs. 6.4 and p < 0.01), MTV (all p < 0.01) and TLG (all p < 0.01) than benign incidentalomas. All volumetric PET parameters had higher area under the curve (AUC) than SUVmax. SUVmax AUC was 0.835 [95 % confidence interval (CI): 0.728-0.942]. MTV 2.5 and TLG 2.5 had the highest performance for predicting malignant PI. MTV2.5 AUC was 0.871 (95 % CI: 0.775-0.968), and TLG2.5 AUC was 0.882 (95 % CI: 0.797-0.967). Using TLG 2.5 greater than 29.8 as the cut-off point, the sensitivity and specificity for malignancy prediction were 94.1 % and 82.6 %, respectively. Conclusion In this study, in which the effectiveness of volumetric parameters in the diagnosis of PI was evaluated for the first time, it was shown that they could potentially have clinical value along with SUVmax.Öğe A Rare Case of Pulmonary Alveolar Microlithiasis with Diffuse Lung Uptake on Bone Scintigraphy(Galenos Publ House, 2022) Sen, Ahmet Eren; Sahin, Ozlem; Aydin, Zeynep; Kaya, Bugra; Erol, Caglagul[Abstract Not Availabe]Öğe Synthesis of asymmetrical tridendate Schiff bases and metal complexes and investigation of anticarcinogen effects on human colon and cervical cancers(Taylor & Francis Inc, 2017) Sahin, Mustafa; Korkmaz, Hatice; Kocak, Nuriye; Sahin, Ozlem; Karakurt, Serdar; Yilmaz, MustafaThe metal complexes of Zn(II), Ni(II), Cu(II) and Pb(II) with asymmetrical Schiff bases were synthesized. The asymmetrical Schiff base was obtained through the condensation of 1,2-phenylenediamine, 4-methyl-1,2-phenylenediamine, 2-hydroxy-1-napthaldehyde and biphenyl-4-carbaldehyde. The new Schiff base ligands (L-1' and L-2') and their metal complexes were characterized by TG/DTG, FT-IR, H-1-NMR, UV-Vis, ESR, powder XRD, elemental analysis, magnetic moment and fluorescence studies. The powder XRD studies indicate that Co(II) and Cu(II) complexes are amorphous, while Ni(II) and Zn(II) complexes are crystalline. The anticarcinogenic effects of L-1' and L-2' were also investigated against colon (SW-620) and cervical cancer (HeLa) cell lines and compound L-2' was found to possess the highest anticarcinogenic potential, with 16.7 mu M and 27.5 mu M of IC50 values for HeLa and SW620 cells, respectively.
