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Öğe Hematopoietic Stem Cell Transplantation From Unrelated Donors in 2 Cases of Interleukin-10 Receptor Deficiency: Is Surgery Not a Requirement?(Lippincott Williams & Wilkins, 2019) Uygun, Dilara F. Kocacik; Uygun, Vedat; Daloglu, Hayriye; Ozturkmen, Seda; Karasu, Gulsun; Reisli, Ismail; Sayar, ErsinMutations in interleukin-10 and its receptors cause infantile inflammatory bowel disease (IBD), a hyperinflammatory disorder characterized by severe, treatment-refractory colitis, multiple abscesses, and enterocutaneous fistulas. Patients with infantile IBD often require several surgical interventions, including complete colectomy, and hematopoietic stem cell transplantation is currently the only known medical therapy. Traditionally, operative management has been preferred before stem cell transplantation because of the latter's increased susceptibility to procedural complications; however, surgical intervention could be delayed, and possibly reconsidered, because our 2 patients with infantile IBD demonstrated a rapid response to treatment via engraftment.Öğe The Ineffectiveness of Tacrolimus in an Infant With a Mutation in the IL-10 Receptor(Lippincott Williams & Wilkins, 2016) Sayar, Ersin; Yucel, Aylin; Eisele, Bianca; Sayar, Esra Hazar; Glocker, Erik; Yuksekkaya, Hasan Ali[Abstract Not Availabe]Öğe Langerhans cell histiocytosis in IPEX syndrome: Possible role for natural regulatory T cells?(Wiley, 2014) Sayar, Ersin; Uygun, Dilara F. Kocacik; Islek, Ali; Hazar-Sayar, Esra; Akkaya, Bahar; Vignoli, Marina; Gambineri, Eleonora[Abstract Not Availabe]
