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Antioxidant and Anti-Atherogenic Properties of Hawthorn Vinegar in Drosophila melanogaster Fed a High-Fat Diet
(New Century Health Publishers, Llc, 2022) Sayin, Kubra; Gunes, Eda
Consumption of vinegar has been associated with protection against hyperglycemia, dyslipidemia, and hypertension. Hawthorn is a medicinal plant with hypolipidemic, anti-inflammatory, digestive modulator, antimicrobial, antioxidant, cardiac stimulant, and hypotensive properties. Therefore, Hawthorn vinegar rich in bioactives (epicatechin, triterpene, saponins, oligomeric procyanidins, chlorogenic acid, and flavonoids) may present a greater value as a functional food for the management of lifestyle diseases. Drosophila melanogaster, when placed on a high-fat diet, exhibit decreased life span and increased antioxidant enzymes. In this high-fat diet fly model, the Hawthorn vinegar led to a significant increase in mean life span, antioxidant enzyme activities, and reduction in malonyldialdehyde level. Furthermore, in vitro studies showed inhibition of alpha-glucosidase and alpha-amylase, and angiotensin-converting enzyme II activities, the measures of antiglycemic and antihypertensive potentials, respectively.