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    Cognitive Functions and Serum BDNF, GDNF, VEGF, Phoenixin-20 and IL-12 Levels of Half-Marathon Runners Aged 50 and Over
    (Wiley, 2023) Sen, Aysu; Yargic, Melda Pelin; Celen, Murat Cenk; Pehlivanoglu, Suray; Kostak, Feyza; Karakus, Behiye Nur; Kiziltan, Erhan
    [Abstract Not Availabe]
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    The effects of chronic restraint stress on empathy-like behaviour in rats
    (Elsevier Ireland Ltd, 2021) Sen, Aysu; Kara, Ali Yucel; Koyu, Ahmet; Simsek, Fatma; Kizildag, Servet; Uysal, Nazan
    It is clearly known that psychological stress is an important threat to health in today's modern societies. Recent studies have shown that acute stress causes an increase in positive social behaviours such as prosocial behaviour and devotion which are components of empathic behaviour. Neuropsychiatric manifestations such as anxiety and depression may affect empathic behaviour. The aim of this study was to investigate the effects of chronic restraint stress on empathy-like behaviour and the histopathological changes in the amygdala, prefrontal cortex in the adrenal glands and thymus, as well as the neurochemical pathways associated with empathy, oxytocin and vasopressin. The chronic stress group was subjected to restraint stress daily for 14 days after all subjects were trained to rescue its stressed cagemate using empathy test equipment for 12 days. It was observed that chronic restraint stress had no effect on empathy-like behaviour in rats. Vasopressin levels in amygdala was increased in chronic stress group compared to control group. Anxiety and depression indicators did not change in both groups. In the open field test, control group spent more time in thigmo zone compared to chronic stress group. Adrenal glands relative weights and apoptotic cell ratios were significantly higher in the chronic stress group compared to the control group (expectedly). Although there was no significant difference in behavioral tests, histopathological changes were detected. In subsequent studies, it is appropriate to examine the effects of different types of stress applications, gender-related changes, and other neurochemical pathways associated with stress and empathy.
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    Effects of Mu Opioidergic Receptors on Endoplasmic Reticulum Stress in the Hypothalamus on Rats
    (Wiley, 2023) Sen, Aysu; Gunes, Canan Eroglu; Caliskan, Zeynep; Erkaya, Zeliha; Dursun, Ebru Nur; Kurar, Ercan; Kutlu, Selim
    [Abstract Not Availabe]
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    Evaluation of Histopathological Effects of Acamprosate Use on Kidneys in Alcohol-Dependent Rats
    (Aves, 2023) Ozdengul, Faik; Gultekin, Burcu; Kusen, Hande; Karakus, Behiye Nur; Sen, Aysu
    Objective: Alcohol addiction is one of the growing global addiction threads. The present study aims to investigate histopathological effects of acamprosate, which is widely used in the treatment of alcohol dependence, on kidneys. Methods: Rats were divided into 4 groups. The control group was given 10 mg/kg/day saline, and the alcohol group was given 10 mg/kg/day ethanol, diluted with 10 mg/kg/day saline. To the acamprosate group, 200 mg/kg/day acamprosate diluted with 10 mg/kg/day saline was given. The alcohol + acamprosate group was given 10 mg/kg/day ethanol diluted with 10 mg/kg/day saline, then combined with 200 mg/kg/day acamprosate. On the 21st day, after the study began, signs of alcohol withdrawal syndrome in the rats were evaluated. On the 22nd day, kidney tissues of the rats were extracted. Results: Histopathological evaluation revealed that kidney tissues of the control group had normal structure. It was determined that Bowman's spaces were close to normal in kidneys of the alcohol group. In kidneys of the acamprosate group, an increased Bowman's space distance and intense tubular degeneration, shedding in tubule epithelial cells, and tubular dilatation were detected (P <.05). In kidneys of the alcohol + acamprosate group, Bowman's space distance was better than the acamprosate group, but tubular degeneration, shedding in tubule epithelial cells, and tubular dilatation continued (P <.05). Our findings revealed that the use of acamprosate alone produced serious histopathological consequences for kidneys. Conclusion: It has been understood that it is important to control kidney health at certain intervals during the period of alcohol-dependent individuals without any kidney disease receiving acamprosate treatment.
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    Investigation of the effect of trazodone on spontaneous and acetylcholine-induced bladder detrusor smooth muscle contractions
    (Kare Publ, 2022) Burunsuz, Ozge; Ozdengul, Faik; Gica, Sakir; Sen, Aysu; Sahin, Zafer
    Objective: The management of psychiatric patients is often complicated by medical comorbidities, complex pharmacological regimens, and side effects secondary to these regimens. In the current study, it was aimed to investigate the effects and mechanism of action of trazodone on rat bladder smooth muscle contractility in vitro. Method: Sixteen adult male Wistar albino rats were euthanized by the cervical dislocation method following ether anesthesia. Two muscle strips of 2x10 mm in size were prepared vertically from the bladder by opening a longitudinal incision from the neck of the bladder in the direction of the apex. The strips were tied properly and hung in the organ bath. All contraction amplitudes and frequencies were recorded. After a 45-min adaptation period, contractions were induced by applying 10(-5) M acetylcholine (ACh) to all spontaneously contracting bladder strips. After 20 min, doses of trazodone (10(-9) M vs 10(-3) M) were given cumulatively. The resulting effects were recorded. Results: The groups were compared within themselves: a significant difference was found between the initial tensions in the group with ACh-induced contractions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-7), 10(-6) , 10(-5), 10(-4), and 10(-3) M doses (p<0.0001). In the group with spontaneous contractions, a significant difference was found between the initial tensions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-5), and 10(-4) M doses (p<0.0001). Conclusion: Results showed that trazodone had a significant inhibitory effect on bladder smooth muscle contractions in vitro, especially at concentrations of 10(-4) and 10(-3) M.
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    Investigation of the effect of trazodone on spontaneous and acetylcholine-induced bladder detrusor smooth muscle contractions
    (Kare Publ, 2022) Burunsuz, Ozge; Ozdengul, Faik; Gica, Sakir; Sen, Aysu; Sahin, Zafer
    Objective: The management of psychiatric patients is often complicated by medical comorbidities, complex pharmacological regimens, and side effects secondary to these regimens. In the current study, it was aimed to investigate the effects and mechanism of action of trazodone on rat bladder smooth muscle contractility in vitro. Method: Sixteen adult male Wistar albino rats were euthanized by the cervical dislocation method following ether anesthesia. Two muscle strips of 2x10 mm in size were prepared vertically from the bladder by opening a longitudinal incision from the neck of the bladder in the direction of the apex. The strips were tied properly and hung in the organ bath. All contraction amplitudes and frequencies were recorded. After a 45-min adaptation period, contractions were induced by applying 10(-5) M acetylcholine (ACh) to all spontaneously contracting bladder strips. After 20 min, doses of trazodone (10(-9) M vs 10(-3) M) were given cumulatively. The resulting effects were recorded. Results: The groups were compared within themselves: a significant difference was found between the initial tensions in the group with ACh-induced contractions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-7), 10(-6) , 10(-5), 10(-4), and 10(-3) M doses (p<0.0001). In the group with spontaneous contractions, a significant difference was found between the initial tensions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-5), and 10(-4) M doses (p<0.0001). Conclusion: Results showed that trazodone had a significant inhibitory effect on bladder smooth muscle contractions in vitro, especially at concentrations of 10(-4) and 10(-3) M.