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Öğe 3rd and 4th Degree Perineal Tears that Occurs During Vaginal Delivery(Marmara Univ, Inst Health Sciences, 2022) Senturk, Mustafa; Yavuz, YusufObjective: Perineal injuries are common in vaginal delivery. In this study, we aimed to investigate the factors affecting the degree of perineal injury and the effect of injury degree on incontinence. Methods: Fifteen patients, underwent sphincter repair by the general surgery unit, who had perineal tear during normal vaginal delivery between January 2018 and March 2019 in our hospital and were retrospectively evaluated. Those with grade 3a and 3b perineal tears were divided into 2 groups as group-1, and those with grade 3c and grade 4 perineal tears as group-2. Episiotomy type, fetal characteristics [head circumference and birth weight], early postoperative continence findings were compared in between groups. Results: The average age of the patients was 30 +/- 8.7 years. When the groups were compared, there was no significant superiority of episiotomy in terms of perinea! injury (p=0.07). 4 patients had 3a, 3 patients had 3b, 6 patients had 3c and 2 patients had fourth-degree perineal injuries. The average birth weight of the newborns was 3438 +/- 492 g, and the head circumference was 34.33 +/- 1.23 cm. There was no significant difference in incontinence between the groups (p=0.55). Conclusion: The treatment of anorectal injuries is surgery. The method of treatment varies according to the time elapsed between injury and intervention, fecal contamination, degree of injury, general condition of the patient, presence of accompanying injury, experience and preference of surgeon. We think that sphincter damage during delivery can be looked after successfully with early diagnosis and intervention before tissue edema develops.Öğe Acute appendicitis in pregnancy(Turkish Assoc Trauma Emergency Surgery, 2021) Yavuz, Yusuf; Senturk, Mustafa; Gumus, Tufan; Patmano, MehmetBACKGROUND: Acute appendicitis is the most common cause of non-obstetric acute abdomen in pregnant women. We examined the patients who were admitted to our emergency department with abdominal pain and diagnosed with acute appendicitis in the light of the literature. METHODS: Seventeen pregnant patients with acute appendicitis who were admitted to the emergency department of Sanliurfa Training and Research Hospital between the years of 2016-2019 were retrospectively analyzed using an electronic recording system. Our patients were evaluated concerning age, gestational week, clinical status, the operation performed, ultrasonography results, pathology results, presence of additional diseases, laboratory results and hospital stay length. RESULTS: The mean age of our patients was 25.5 (18-41) years. Three patients were in the first trimester (17.6%), 11 patients were in the second trimester (64.8%), and three patients were in the third trimester (17.6%) at the time of admission. All of our patients had abdominal pain. Acute appendicitis was detected in 11 patients, while it was not detected in six patients on the USG examination. Two patients having term delivery underwent caesarean section with concurrent appendectomy. The mean hospital stay length was 2.9 (2-5) days. Histopathologically, 13 (86.7%) of our operated patients were diagnosed with appendicitis. No additional problems were observed in the mothers and infants in the postoperative period. CONCLUSION: Acute appendicitis should be considered as a non-obstetric pathology in pregnant patients admitted to the emergency department with abdominal pain. We think that it is important for both maternal and infant health to examine this condition, which shows differences concerning clinical course and physical examination, with a meticulous and multidisciplinary approach.Öğe Acute appendicitis in pregnancy(Turkish Assoc Trauma Emergency Surgery, 2021) Yavuz, Yusuf; Senturk, Mustafa; Gumus, Tufan; Patmano, MehmetBACKGROUND: Acute appendicitis is the most common cause of non-obstetric acute abdomen in pregnant women. We examined the patients who were admitted to our emergency department with abdominal pain and diagnosed with acute appendicitis in the light of the literature. METHODS: Seventeen pregnant patients with acute appendicitis who were admitted to the emergency department of Sanliurfa Training and Research Hospital between the years of 2016-2019 were retrospectively analyzed using an electronic recording system. Our patients were evaluated concerning age, gestational week, clinical status, the operation performed, ultrasonography results, pathology results, presence of additional diseases, laboratory results and hospital stay length. RESULTS: The mean age of our patients was 25.5 (18-41) years. Three patients were in the first trimester (17.6%), 11 patients were in the second trimester (64.8%), and three patients were in the third trimester (17.6%) at the time of admission. All of our patients had abdominal pain. Acute appendicitis was detected in 11 patients, while it was not detected in six patients on the USG examination. Two patients having term delivery underwent caesarean section with concurrent appendectomy. The mean hospital stay length was 2.9 (2-5) days. Histopathologically, 13 (86.7%) of our operated patients were diagnosed with appendicitis. No additional problems were observed in the mothers and infants in the postoperative period. CONCLUSION: Acute appendicitis should be considered as a non-obstetric pathology in pregnant patients admitted to the emergency department with abdominal pain. We think that it is important for both maternal and infant health to examine this condition, which shows differences concerning clinical course and physical examination, with a meticulous and multidisciplinary approach.Öğe Appendix Vermiformis Morphology in the Adult Age Group: What we've learned from more than 250 Patients on Computer Tomography(Gazi Univ, Fac Med, 2021) Ozer, Halil; Yazol, Merve; Senturk, MustafaObjective: This article assesses normal appendix vermiformis morphology in the adult age group by computed tomography (CT). Material and Methods: A total amount of 256 cases who had a clinical suspicion of urolithiasis and underwent abdominal-pelvic non-enhanced CT were enrolled in the study. Appendiceal diameter, wall thickness, intraluminal content, and the presence of an appendicolith were evaluated. Variables summarized by descriptive statistics. Groups were compared using the chi-square test and student t-test. Results: The mean diameter of the appendix was 6.5 +/- 1.2 mm (range, 3.1-9.7 mm) in all cases. Intraluminal air content detected in 199 (77.7%) cases. In 57 (22.3%) cases without air within the lumen, the appendix was evaluated as collapsed or isodense. Mean appendix diameter was 6.7 +/- 1.1 mm in cases with air in the lumen and the mean appendix diameter was 5.8 +/- 1.3 mm in cases with isodense or collapsed appearances (p < 0.001). Mean wall thickness of appendix determined as 1.7 +/- 0.3 mm (range, 0.9-3.1 mm). Appendicolith was detected in seven (2.7%) cases. Conclusion: In the presence of air in the appendiceal lumen, the increase in diameter can be interpreted normal unless not accompanied by inflammatory findings. It should be kept in mind that normal appendix diameter may be 6 mm or above when the intraluminal content of the appendix could not be distinguished.Öğe Appendix Vermiformis Morphology in the Adult Age Group: What we've learned from more than 250 Patients on Computer Tomography(Gazi Univ, Fac Med, 2021) Ozer, Halil; Yazol, Merve; Senturk, MustafaObjective: This article assesses normal appendix vermiformis morphology in the adult age group by computed tomography (CT). Material and Methods: A total amount of 256 cases who had a clinical suspicion of urolithiasis and underwent abdominal-pelvic non-enhanced CT were enrolled in the study. Appendiceal diameter, wall thickness, intraluminal content, and the presence of an appendicolith were evaluated. Variables summarized by descriptive statistics. Groups were compared using the chi-square test and student t-test. Results: The mean diameter of the appendix was 6.5 +/- 1.2 mm (range, 3.1-9.7 mm) in all cases. Intraluminal air content detected in 199 (77.7%) cases. In 57 (22.3%) cases without air within the lumen, the appendix was evaluated as collapsed or isodense. Mean appendix diameter was 6.7 +/- 1.1 mm in cases with air in the lumen and the mean appendix diameter was 5.8 +/- 1.3 mm in cases with isodense or collapsed appearances (p < 0.001). Mean wall thickness of appendix determined as 1.7 +/- 0.3 mm (range, 0.9-3.1 mm). Appendicolith was detected in seven (2.7%) cases. Conclusion: In the presence of air in the appendiceal lumen, the increase in diameter can be interpreted normal unless not accompanied by inflammatory findings. It should be kept in mind that normal appendix diameter may be 6 mm or above when the intraluminal content of the appendix could not be distinguished.Öğe Approach to Traumatic Diaphragm Injuries: Single Center Experience(Taiwan Soc Emergency Medicine, 2021) Senturk, Mustafa; Cakir, Murat; Akbulut, Muhammed Ali; Yesildag, KerimBackground: Traumatic diaphragm injuries are rare. After blunt trauma, injuries occur with a 1-7% rate. This rate increases up to 15% in penetrating injuries. Diagnosis may be difficult and imaging tests may be misleading. The misdiagnosis may lead to herniated abdominal organs towards the intrathoracic cavity, with a mortality rate between 30% and 60%. This study was designed to investigate the data of patients operated for diaphragmatic injury in our clinic. Methods: The files of trauma patients admitted to our hospital between 2014-2019 were reviewed retrospectively. The files of cases with diaphragmatic injury were examined. Patients were evaluated in terms of age, sex, type of injury, localization, additional organ injuries, grade, surgical method, and mortality. Values were statistically analyzed. Results: A total of 20 patients were included in the study. Of the patients, 7 were female and 13 were male. The mean age was 32.7 (17-52) years. Of the cases, 10 were with stab wounds while 4 were incar traffic accidents and 6 were gunshot wounds. Although all patients had thoracoabdominal injuries, 4 patients had additional pelvic injuries. Of the cases, 14 were accompanied with lung injury while 5 with intestinal, 4 with the spleen, 3 with liver, and 2 with cardiovascular injury. Patients with intestinal resection performed had a longer hospitalization period than others. When the severity of the injury was evaluated, grade 3 injuries were detected most commonly, whereas 3 patients had grade 1, 2, and 4 injuries. Grade 5 injury was detected in 1 patient. Primary repair was performed in 18 patients and mesh repair was performed in 2 patients. In three cases, the repair was performed with a thoracic way. One patient died on the postoperative first day. Conclusions: Diaphragmatic injuries that may be missed during imaging may be damaged with many organs. Diaphragmatic injuries should be kept in mind in the upper abdominal and thoracic injuries.Öğe Changes in cerebral oxygen saturation with the Trendelenburg position and increased intraabdominal pressure in laparocopic rectal surgery(Turkish Surgical Assoc, 2022) Alkan, Selman; Cakir, Murat; Senturk, Mustafa; Varman, Alper; Buyukbezirci, Gulcin; Yildirim, Mehmet Aykut; Bicer, MehmetObjective: Position changes and increased intra-abdominal pressure in laparoscopic interventions lead to some physiopathological changes. There is no definite information in the literature regarding cerebral oxygen saturation in patients undergoing colorectal surgery. Our aim was to investigate whether there is oxygen saturation change in the brain tissue in pneumoperitoneum and the Trendelenburg position during laparoscopic rectal surgery. Material and Methods: Cerebral oxygen saturation was measured in 35 patients who underwent laparoscopic rectal surgery in the Trendelenburg position. Measurements were made under general anesthesia in the pneumoperitoneum and the Trendelenburg position. Results: The values that are statistically affected by the position are systolic blood pressure, mean arterial blood pressure and cerebral oxygen saturation. The Trendelenburg position does not disturb the cerebral oxygen saturation and it causes an increase in saturation. After pneumoperitoneum occurred, changes in systolic blood pressure, mean arterial blood pressure and brain oxygen saturation were detected. Cerebral oxygen saturation increases with the formation of pneumoperitoneum. Conclusion: The Trendelenburg position and increased intraabdominal pressure during laparoscopic rectal surgery do not impair brain oxygen saturation.Öğe Clinicopathologic and Surgical Characteristics Study of 151 Cases of GIST(Springer, 2021) Senturk, Mustafa; Yildirim, Mehmet Aykut; Cakir, Murat; Kisi, OmerBackground Gastrointestinal stromal tumor (GIST) is the most appearing mesenchymal tumor of the gastrointestinal system. In this study, we are aiming to share the most up to date knowledge about diagnosis and treatment of these tumors by transferring our clinical experience about GISTs. Methods The 151 patients who were operated between 2006-2020 and whose pathological examination was reported as GIST were analyzed retrospectively. Demographic, clinical, and pathological features and treatment methods of patients were evaluated. Results Seeventy-six of the patients were women and 75 of them were men whose age averages were 66.1 (31-86). The most common location was the stomach (55.6%), followed by the small intestine, retroperitoneal, large intestine, rectum, esophagus, and another organ. With surgical intervention, 139 of them had been cured. Twelve of cases were accepted as inoperable. The diameter of tumors in our cases were between 0.4 cm and 35 cm. Determined mitotic activity was <= 5 in 71 patients and 5 < in 80 patients. In 8 of 12 unresectable cases, it has been seen that partial remission after the treatment of 12-month tyrosine kinase inhibitors, C-KIT, was positive in 96.7% of our cases. CD34 and Ki-67 was analyzed in patients. CD34 was found positive in 98 (64.9%) of them, Ki-67 was positive in 82 (54.3%) patients. Patients had been observed for 40 months. Conclusion Despite GISTs are not appearing frequently, nowadays they have started to be seen more frequently than before with the growing present-day diagnostic methods. The ideal treatment is performing radical resection without leaving any tumor cells behind. Tyrosine kinase inhibitors have an important place in unresectable cases.Öğe Clinicopathological Characteristics of Gastroenteropancreatic Neuroendocrine Tumors 10 Years of Experience From a Single Center(Lippincott Williams & Wilkins, 2022) Senturk, Mustafa; Acar, Berkan; Yildirim, Mehmet Aykut; Cakir, Murat; Kucukkartallar, Tevfik; Vatansev, CelalettinObjectives Gastorenteropancreatic neuroendocrine (GEP-NET) tumors are the second most common tumors of the gastrointestinal tract. We aimed to investigate the clinicopathological features and factors affecting the prognosis of patients with GEP-NET. Methods Clinicopathological features of 158 patients were evaluated, including tumor location, TNM stage and grade, pathological features, presence of lymph nodes and distant metastases at the time of diagnosis, maximum tumor diameter and treatment details. Also, follow-up information was analyzed to discover possible prognostic factors. Results The most common primary site is pancreas (45.6%, n = 72). Most of the GEP-NETs were nonfunctional (93.6%, n = 148). Of the 158 patients, 94 (59.5%) were grade 1, 46 (29.1%) grade 2, and 18 (11.4%) grade 3. The 1-year, 3-year, and 5-year survival rates were 82.3% (130/158), 61.4% (70/114), and 47.2% (35/74), respectively. In multivariate analysis, histological grade (P = 0.04) and TNM stage (P < 0.001) were independent prognostic factors for survival in patients with GEP-NET. Conclusions They are increasing in frequency and are the most common tumors in the pancreas. Nonfunctional tumors made up the majority of cases. The main treatment was surgical resection. Histological grade and TNM stage are independent prognostic factors.Öğe Comparison of primary repair and repair with polyglycolic acid coated tube in recurrent laryngeal nerve cuts (an experimental study)(Excerpta Medica Inc-Elsevier Science Inc, 2020) Senturk, Mustafa; Cakir, Murat; Tekin, Ahmet; Kucukkartallar, Tevfik; Yildirim, Mehmet Aykut; Alkan, Selman; Findik, SiddikaBackground: Recurrent laryngeal nerve (RLN) injury is an important complication of thyroid surgery. In our study, we aimed to compare the effects of primary repair and polyglycolic acid (PGA) coated tube repair on nerve function and regeneration in RLN cuts in rats. Methods: Twenty seven rats were used for the study. Group-1 with only nerve cuts, group-2 with primary repair, and group-3 with conduit repair. The study was planned over two-stage surgery. In the first step, nerve defect formation and nerve repair were performed in the same session. In the second step, samples were taken from the subjects for histopathological. Results: Vocal cord mobility was proportionally higher in group-3 than other groups. However, there was no statistically significant difference between the groups (p < 0.239). The mean number of highest axons were detected the group-3. Conclusions: We think that PGA coated conduit can provide a more accurate orientation of nerve fibers by creating an isolated environment when compared to the primary repair. And this may be the cause of functional improvement in the nerve. (C) 2019 Elsevier Inc. All rights reserved.Öğe Comparison of the efficacy of growth factor collagen and antibiotic collagen on colon anastomosis in experimental animals with peritonitis(Springer India, 2021) Yildirim, Mehmet Aykut; Cakir, Murat; Findik, Siddika; Kisi, Omer; Senturk, MustafaIntroduction In spite of advances in surgical techniques, the significance of anastomosis leak continues in colorectal surgery. There is no ideal method in spite of all studies and technical advances in this field. Our aim of this study was to use fibroblast growth factor collagen (FGF-C) and antibiotic collagen (AB-C) to increase the rate of anastomosis healing in experimental animals with peritonitis. Methods This animal experimental study received ethics committee approval. The animals were divided into three groups of seven animals each; the first group was control, the second group was the fibroblast growth factor collagen group, and the third group was the antibiotic collagen group. Under anesthesia, more than 50% of the colonic lumen was opened 4-5 cm distal to the ileocecal junction to create a defect. Twenty-four hours later, primary anastomosis was performed. The second group had the anastomosis line covered with a cover containing FGF-C. The third group had the anastomosis line covered by material containing AB-C. The experiment was concluded on the postoperative 7th day, and the anastomosis burst pressure, tissue hydroxyproline level, and histopathological assessment were performed. Results Though the burst pressure was higher in the experimental groups, it was not statistically significant. In the second and third groups, vascular proliferation and fibroblastic activity appeared to be better than in the control group. Hydroxyproline values were statistically significant in the experimental groups compared to the control group. Conclusion FGF-C and AB-C may have potential utility in anastomosis healing, especially in those susceptible to infection due to anastomosis leak.Öğe Comparison of two different techniques in emergency surgery of colon diverticulitis: Hartmann's procedure and resection with primary anastomosis(Wiley, 2022) Senturk, Mustafa; Celik, Abdulkadir; cakir, Murat; Yildirim, Mehmet Aykut; Belviranli, Mehmet MetinColon diverticula may require emergency or elective surgery depending on its complications. Our aim is to compare the Hartmann's procedure and resection with primary anastomosis in the patients with colon diverticulitis and to demonstrate the surgical approach of our clinic. Patients were evaluated retrospectively who were operated for colon diverticulitis between January 2010 and January 2020. The patients who underwent emergency surgery for left colon diverticulitis were divided into two groups as patients with primary anastomosis resection (group 1) and Hartmann's procedure (group 2) and the groups were compared. In the aspect of the development of complications there was no remarkable difference between the groups (P = .56). Postoperative early mortality rate was similar in two groups (P = .12). According to the Hinchey classification, 31.7% of the cases were stage I, 9.8% were stage II, 31.7% were stage III, and 26.8% were stage IV. There was not a distinction in morbidity and mortality rates between Hartmann's procedure and resection with primary anastomosis. The best surgical approach should be determined by considering the operation to be performed, the patient's preferences, clinical status, and the predicted results of the surgical treatment of perforated diverticulitis.Öğe Effects of Tumor Volume on Lymph Node Involvement and Prognosis at Stage pt3 Colon Cancers(Springer India, 2022) Senturk, Mustafa; Ozer, Halil; Celik, Abdulkadir; Yildirim, Mehmet Aykut; Cakir, Murat; Vatansev, CelalettinSome studies showed that the increase of tumor size has a negative effect on survival in colon cancers. Our study aims to assess the effects of tumor volume on lymph node positivity and prognosis in stage pT3 colon cancers. All patients who underwent surgery for colon cancer in our clinic were evaluated retrospectively. The study included 213 patients who were diagnosed with colon adenocarcinoma and reported as pathologic. Preoperative abdomen computed tomography scans were used for measurements of tumor volume. Tumor volumes were compared according to the pathological lymph node involvement. Cut-off values were determined with ROC analysis. The cases were divided into groups according to the determined cut-off value and data compared. Mean tumor volume was found to be higher in the lymph node-positive group (p=0.01). The higher number of removed lymph nodes and lymph node positivity was detected more in cases that were above the cut-off value (p=0.003 and p=0.004, respectively). The mean survival time was 37.3 +/- 1.3 months. There was no correlation between tumor volume and the overall survival time (p=0.21). According to data comparison of the lymph node positivity, Kaplan-Meier analysis showed that the increase of the N stage reduces the 5-year survival rate (for the N0, N1, N2 stages, 60%, 52%, 35%, respectively). Tumor volume is correlated with lymph node involvement. It has been shown that increasing the N stage has a negative effect on prognosis. Our study showed that tumor volume has no significant impact on survival but may have an indirect effect on prognosis.Öğe The Investigation of 14 Appendiceal Mucocele Cases Encountered in 4850 Appendectomy Patients(Springer, 2021) Senturk, Mustafa; Yavuz, Yusuf; Alkan, Selman; Kafadar, Mehmet TolgaBackground Appendiceal mucocele is a rarely seen disease which occurs when the appendix lumen is filled and obstructed by mucous. In our study, we aimed to reveal the surgical approach of our clinic, features of tumors, and clinical presentations in line with literature in cases of appendix mucocele. Methods Fourteen appendix mucocele patients who were admitted in our hospital between 2012 and 2019 were examined retrospectively in the electronic recording medium. Our patients were evaluated in terms of age, gender, clinical status, operation, imaging results, and pathology results. Results Of the fourteen patients, 12 applied to the emergency department and 2 to the general surgery clinic. All of our patients had abdominal pain at the time of admission. In the physical examination, 5 (35%) patients had defenses, 10 (71%) patients had rebound tenderness, and 12 (85%) patients had tenderness. In preoperative imaging studies, 11 patients were interpreted as having acute appendicitis and 3 patients were evaluated as having appendix mucocele. The pathological results were reported as 6 patients had appendiceal mucocele and 8 patients had appendiceal mucocele together with acute appendicitis. Conclusion Appendiceal mucocele is a disease which generally causes similar clinical findings of acute appendicitis. Ultrasound and CT may be useful in preoperative diagnosis. Surgical treatment options of mucocele are open or laparoscopic appendectomy, cecum resection, and right hemicolectomy. Although its incidence is low, due to pseudomyxoma peritonei, it is a pathology that requires careful surgery.Öğe Lifestyle and Chronic Constipation in Medical Students(Hindawi Ltd, 2021) Yildirim, Mehmet Aykut; Cakir, Murat; Bicer, Mehmet; Senturk, Mustafa; Yonar, Harun; Gur, Merve Nur; Akiner, Zeliha NurAim. Constipation is one of the most common complaints of the digestive system indicated with an increase in defecation frequency, difficulty in defecation, and hard and strained defecation. Environmental, personal, and genetic factors may be affecting constipation although the affecting factors have not yet been thoroughly explained. The aim of this study was to investigate constipation frequency and lifestyles in medical students. Method. The population was selected among medical students for the study, which was planned as a survey study. Demographic data of all the participants and the factors suggested to affect constipation were questioned and analyzed. Results. The study covered a total of 425 medical students. Among the students reporting constipation, 2.86% were in their first year of medical school, while 7.53% were in the third year and 9.09% were in the sixth year. The rate of students reporting constipation and familial history was statistically significant. While regular eating habits were reported in the first and third years, this rate was much lower in the sixth year group working at clinical departments. The results of our study did not reveal any significant relationship between daily intake of water and constipation. There was, however, a significant relationship between stress and constipation. Conclusion. The results of our study showed that medical education did not curb constipation frequency. We believe that stress is significant in constipation. The data we collected indicate that regular eating habits and excess liquid intake are not as effective as suggested in the treatment of constipation.Öğe Reasons for transition to open surgery in laparoscopic cholecystectomy(Bayrakol Medical Publisher, 2021) Senturk, Mustafa; Cakir, Murat; Bicer, Mehmet; Yildirim, Mehmet AykutAim: Laparoscopic cholecystectomy is a minimally invasive surgical technique that has become widespread since the 1980s. Many factors are effective in the conversion to open surgery. This study aimed to investigate the rates and reasons for the conversion to open in laparoscopic cholecystectomy surgeries in our hospital. Material and Methods: This study aimed to examine 3263 cholecystectomy cases with the conversion to open during surgery between June 2014 and June 2019. Patients were examined in terms of age, sex, comorbidities, acute cholecystitis attack status, previous surgery, adhesion, gallbladder wall thickness, revealing surgical anatomical structure, surgical complications, length of hospital stay, and mortality. The results were evaluated statistically. Results: Data of 70 patients, who were performed laparoscopic cholecystectomy with the conversion to open surgery during the procedure, were reviewed. The conversion rate was 2.3%. Among the patients, 28 were female and 42 were male. Sixty-two of the patients had an episode of acute cholecystitis. The most common reason for the conversion was that the anatomy could not be revealed . Discussion: It should be kept in mind that laparoscopic cholecystectomy surgery, which is interpreted as a simple surgical procedure, can always be converted to an open surgery and there may be vital complications.Öğe Rectal Prolapse, Perineal Repair (Perineal Rectosigmoidectomy: Altemeier Procedure)(Lippincott Williams & Wilkins, 2021) Cakir, Murat; Senturk, Mustafa[Abstract Not Availabe]Öğe Role of thiol-disulfide hemostasis in early diagnosis of acute mesentery ischemia: An experimental study(Turkish Assoc Trauma Emergency Surgery, 2022) Yildirim, Mehmet Aykut; Kocabas, Rahim; Kilinc, Ibrahim; Simsek, Gurcan; Senturk, Mustafa; Cakir, Murat; Belviranli, MetinBACKGROUND: Acute mesenteric ischemia (AMI) is a rarely observed acute abdominal disease that may be mortal and is difficult to diagnose early. The aim of our study is to assess the role of Thiol-Disulphide Haemostasis (TDH), a new method for AMI which still has no specific biochemical markers for early diagnosis, and to assess it together with Ischemia-Modified Albumin (IMA) which METHODS: The study included 32 Wistar albino rats in four groups. The 1st group (n=8) was the control group, 2nd group (n=8) was the sham group, 3rd group (n=8) had 3 h of arterial mesentery ischemia and the 4th group (n=8) had 6 h of arterial mesentery ischemia. RESULTS: In the 3rd and 6th h, serum total thiol and native thiol values significantly reduced (p<0.001), while serum disulfide, IMA, and lactate values clearly increased (p<0.001). Serum thiol values were observed to reduce from the 1st h. CONCLUSION: TDH changes in the early period of AMI. The TDH parameters can be used with IMA as diagnostic parameters for patients with suspected AMI in the early period.Öğe Role of thiol-disulfide hemostasis in early diagnosis of acute mesentery ischemia: An experimental study(Turkish Assoc Trauma Emergency Surgery, 2022) Yildirim, Mehmet Aykut; Kocabas, Rahim; Kilinc, Ibrahim; Simsek, Gurcan; Senturk, Mustafa; Cakir, Murat; Belviranli, MetinBACKGROUND: Acute mesenteric ischemia (AMI) is a rarely observed acute abdominal disease that may be mortal and is difficult to diagnose early. The aim of our study is to assess the role of Thiol-Disulphide Haemostasis (TDH), a new method for AMI which still has no specific biochemical markers for early diagnosis, and to assess it together with Ischemia-Modified Albumin (IMA) which METHODS: The study included 32 Wistar albino rats in four groups. The 1st group (n=8) was the control group, 2nd group (n=8) was the sham group, 3rd group (n=8) had 3 h of arterial mesentery ischemia and the 4th group (n=8) had 6 h of arterial mesentery ischemia. RESULTS: In the 3rd and 6th h, serum total thiol and native thiol values significantly reduced (p<0.001), while serum disulfide, IMA, and lactate values clearly increased (p<0.001). Serum thiol values were observed to reduce from the 1st h. CONCLUSION: TDH changes in the early period of AMI. The TDH parameters can be used with IMA as diagnostic parameters for patients with suspected AMI in the early period.Öğe Sporadic mesenteric fibromatosis: a single center experience(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2017) Tasci, Halil Ibrahim; Cakir, Murat; Senturk, MustafaObjective: Our aim with this study is to present the surgical approach of our clinic, the characteristics of the tumor, clinical presentation and long-term follow-up results with the literature in the cases of spontaneous mesenteric fibromatosis. Material and Methods: The data collected from 8 cases of patients, who had underwent surgery because of sporadic mesenteric fibromatosis at Necmettin Erbakan University Medical School's Department of General Surgery between January 2005 and December 2014, were retrospectively evaluated. Results: The mean age of the patients was 46.7 +/- 19.9. Four (50%) of the patients were taken into emergency surgery having been diagnosed with ileus, 2 (25%) patients were ascertained to have mesenteric mass upon complaints of obscure abdominal pain, 1 (12.5%) patient underwent surgery on the detection of a mass in the meso of the small intestines during a surgical procedure performed by urologists because of a benign cause and in 1 (12.5%) patient's case, the pathology results of the piece, which was removed after a surgical procedure performed because of a mass that might have been originated from the distal pancreas, was reported to be mesenteric fibromatosis. Only 1 (12.5%) patient had recurrence and necessitated re-operation following an average of 33.5 +/- 34.5 months of follow-up. Conclusion: The fundamental principle in the treatment of this clinically aggressive tumor with a high recurrence rate, although it has the pathological characteristics of a benign tumor, is wide surgical resection.
