Yazar "Sivri, Rukiye Colak" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim Yok
    Öğe
    8-F2-isoprostane, thioredoxin and thioredoxin reductase levels in children with obsessive-compulsive disorder
    (Taylor & Francis Ltd, 2018) Bilgic, Ayhan; Sivri, Rukiye Colak; Kilinc, Ibrahim
    Purpose: Accumulating data demonstrate that oxidative stress may play a crucial role in obsessive-compulsive disorder (OCD). This study aimed to investigate the role of 8-F2-isoprostane, thioredoxin (Trx), and thioredoxin reductase (TrxR) in children with OCD.Materials and methods: Thirty-three drug-free children with OCD and 35 healthy controls were included in this study. The severity of OCD symptoms was assessed via the Children's Yale Brown Obsessive-Compulsive Scale. The severity of anxiety levels was determined through the Screen for Child Anxiety-Related Emotional Disorders. Plasma levels of 8-F2-isoprostane, Trx, and TrxR were measured using commercial enzyme-linked immunosorbent assay kits.Results: Plasma 8-F2-isoprostane, Trx, and TrxR levels did not show any significant differences between patient and control groups. There were no significant correlations between plasma levels of these antioxidants and severity of OCD.Conclusions: Findings of this study did not support the involvement of oxidative stress in the etiology of childhood OCD.
  • Küçük Resim Yok
    Öğe
    Buspirone in the Treatment of Fluoxetine-Induced Sleep Bruxism
    (Mary Ann Liebert, Inc, 2016) Sivri, Rukiye Colak; Akca, Omer Faruk
    [Abstract Not Availabe]
  • Küçük Resim Yok
    Öğe
    Cytokine, chemokine and BDNF levels in medication-free pediatric patients with obsessive-compulsive disorder
    (Springer, 2018) Sivri, Rukiye Colak; Bilgic, Ayhan; Kilinc, Ibrahim
    The aim of this study was to investigate whether the serum levels of IL-12, IL-17, TGF beta, TNF-alpha, sTNFR1, sTNFR2, IL-1 beta, CCL3, CCL24, CXCL8, and BDNF are associated with obsessive-compulsive disorder (OCD) in medication-free children. A total of 44 (22 boys/22 girls) medication-free children with OCD and 40 (23 boys/17 girls) healthy controls were included in this study. The severity of the OCD symptoms were assessed by the Children's Yale-Brown Obsessive-Compulsive Scale and the Maudsley Obsessive-Compulsive Inventory. The Children's Depression Inventory and the Screen for Child Anxiety-Related Emotional Disorders were applied to the children in order to determine depression and anxiety levels. IL-17, IL-12, TGF beta, TNF-alpha, sTNFR1, sTNFR2, IL-1 beta, CCL3, CCL24, CXCL8, and BDNF levels were measured by enzyme-linked immunosorbent assay. Multivariate analysis of covariance (MANCOVA) revealed a significant main effect on both groups for the levels of serum cytokine, chemokine, and BDNF, an effect that was independent of severities of depression and anxiety [Pillai's Trace V = 0.371, F (11, 70) = 3.756, p < 0.001, hp(2) = 0.187]. Analysis of covariance (ANCOVA) indicated that serum TNF-alpha levels were significantly higher in the OCD group than in the control group (p < 0.001). In contrast, serum IL-12 levels were significantly lower in the OCD group than in the control group (p = 0.014). These findings suggest that TNF-alpha and IL-12 may play a role in the pathophysiology of OCD in children. The causal relationship between these proinflammatory cytokines and pediatric OCD requires further investigation.
  • Küçük Resim Yok
    Öğe
    Methylphenidate-Induced Awake Bruxism: A Case Report
    (Lippincott Williams & Wilkins, 2015) Sivri, Rukiye Colak; Bilgic, Ayhan
    Methylphenidate (MPH) is a stimulant that is commonly used in the treatment of attention-deficit/hyperactivity disorder in children and adults. Several reports are available regarding the relationship of MPH use and sleep bruxism. We report the case of a 9-year-old boy who presented with severe awake bruxism after his second dose of sustained release form of MPH treatment, which was confirmed on rechallenge. This is the first report of its kind showing such relationship in the literature.