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Öğe Agomelatine has relaxant effect on isolated rat thoracic aorta through nitric oxide dependent mechanism(Wiley-Blackwell, 2015) Solak, H.; Koca, Ozen R.; Nurullahoglu-Atalik, K. E.; Kutlu, S.[Abstract Not Availabe]Öğe Assessment of myocardial protection with new biochemical markers during on-pump coronary bypass surgery(Wiley-Blackwell, 2014) Gormus, Z. I. Solak; Cicek, M. C.; Solak, H.; Gormus, N.; Kutlu, S.[Abstract Not Availabe]Öğe Cilostazol enhances atorvastatin-induced vasodilation of female rat aorta during aging(Akademiai Kiado Zrt, 2017) Nurullahoglu-Atalik, K. E.; Kutlu, S.; Solak, H.; Koca, R. OzenStatins have cholesterol-independent effects including an increased vascular nitric oxide activity and are commonly used by patients with cardiovascular disease. Such patients frequently have cardiovascular diseases, which may be treated with cilostazol, a platelet aggregation inhibitor. This study was designed to investigate whether combined use of cilostazol would increase the inhibitory effect of statin on vascular smooth muscle and how maturation would affect these responses. Female Wistar rats, aged 3-4 months (young) and 14-15 months (adult), were sacrificed by cervical dislocation and the thoracic aorta was dissected and cut into 3- to 4-mm-long rings. The rings were mounted under a resting tension of 1 g in a 20-ml organ bath filled with Krebs-Henseleit solution. Rings were precontracted with phenylephrine (10(-6) M), and the presence of endothelium was confirmed with acetylcholine (10(-6) M). Then, the concentration-response curves were obtained for atorvastatin alone (10(-10) to 3 x 10(-4) M; control) and in the presence of cilostazol (10(-6) M) in young and adult rat aortas. This experimental protocol was also carried out in aorta rings, which had been pretreated with NG-nitro-L-arginine methyl ester (L-NAME, 10(-4) M). Atorvastatin induced concentration-dependent relaxations in young and adult rat thoracic aorta rings precontracted with phenylephrine. The pIC(50) value of atorvastatin was significantly decreased in adult rat aortas. In addition, pretreatment of aortas with cilostazol enhanced the potency of atorvastatin in both young and adult aortas. Incubation with L-NAME did not completely eliminate the relaxations to atorvastatin in the presence of cilostazol. These results suggest that combined application of cilostazol with atorvastatin was significantly more potent than atorvastatin alone. Combined drug therapy may be efficacious in delaying the occurrence of cardiovascular events.Öğe Cilostazol enhances atorvastatin-induced vasodilation of female rat aorta during aging(Akademiai Kiado Zrt, 2017) Nurullahoglu-Atalik, K. E.; Kutlu, S.; Solak, H.; Koca, R. OzenStatins have cholesterol-independent effects including an increased vascular nitric oxide activity and are commonly used by patients with cardiovascular disease. Such patients frequently have cardiovascular diseases, which may be treated with cilostazol, a platelet aggregation inhibitor. This study was designed to investigate whether combined use of cilostazol would increase the inhibitory effect of statin on vascular smooth muscle and how maturation would affect these responses. Female Wistar rats, aged 3-4 months (young) and 14-15 months (adult), were sacrificed by cervical dislocation and the thoracic aorta was dissected and cut into 3- to 4-mm-long rings. The rings were mounted under a resting tension of 1 g in a 20-ml organ bath filled with Krebs-Henseleit solution. Rings were precontracted with phenylephrine (10(-6) M), and the presence of endothelium was confirmed with acetylcholine (10(-6) M). Then, the concentration-response curves were obtained for atorvastatin alone (10(-10) to 3 x 10(-4) M; control) and in the presence of cilostazol (10(-6) M) in young and adult rat aortas. This experimental protocol was also carried out in aorta rings, which had been pretreated with NG-nitro-L-arginine methyl ester (L-NAME, 10(-4) M). Atorvastatin induced concentration-dependent relaxations in young and adult rat thoracic aorta rings precontracted with phenylephrine. The pIC(50) value of atorvastatin was significantly decreased in adult rat aortas. In addition, pretreatment of aortas with cilostazol enhanced the potency of atorvastatin in both young and adult aortas. Incubation with L-NAME did not completely eliminate the relaxations to atorvastatin in the presence of cilostazol. These results suggest that combined application of cilostazol with atorvastatin was significantly more potent than atorvastatin alone. Combined drug therapy may be efficacious in delaying the occurrence of cardiovascular events.Öğe Comparison of housekeeping genes for qPCR analysis in rat hippocampus: chronic depression model(Wiley, 2019) Kurar, E.; Eroglu, C.; FarukUguz; Ak, Mehmet; Koca, R. O.; Solak, H.; Koc, A.[Abstract Not Availabe]Öğe Comparison of Saphena with Sertraline and Alarin On Human(Wiley, 2019) Gormus, Solak Z., I; Koca, Ozen R.; Solak, H.[Abstract Not Availabe]Öğe Comparison of Sertraline Usage on Human and Rat Atrium(Wiley, 2019) Gormus, Solak Z., I; Solak, H.; Koca, Ozen R.; Gormus, N.[Abstract Not Availabe]Öğe Effect of boron on spontaneous and oxytocin induced contraction in rat myometrium(Wiley-Blackwell, 2014) Kutlu, S.; Akgunlu, M.; Solak, H.; Gormus, Z. I. Solak; Uysal, H.; Ergene, N.[Abstract Not Availabe]Öğe Effects of Sertraline in Healthy and Damaged Rat Aorta(Wiley, 2017) Koc, A.; Gormus, Z. I. Solak; Solak, H.; Koca, R. Ozen; Sahin, Z.; Gormus, N.; Kutlu, S.[Abstract Not Availabe]Öğe Investigation of Effects of Two Chronic Stress Protocols on Depression-Like Behaviors and Brain Mineral Levels in Female Rats: an Evaluation of 7-Day Immobilization Stress(Springernature, 2021) Sahin, Z.; Ozkurkculer, A.; Kalkan, O. F.; Ozkaya, A.; Koc, A.; Koca, R. Ozen; Solak, H.We aimed to investigate the effects of two different chronic immobilization stress protocols on depression-related behaviors and brain mineral levels. Adult female Wistar albino rats were divided into 3 groups as follows (n = 10/group): control, immobilization stress-1 (45 min daily for 7 days), and immobilization stress-2 (45 min twice a day for 7 day). Stress-related behavior was evaluated by means of the forced swimming test (FST) and open field test (OFT). Minerals were analyzed using an inductively coupled plasma mass spectrometer. In the FST, swimming and immobility were significantly lower in the immobilization stress-1 and immobilization stress-2 groups. The climbing duration of the immobilization stress-2 group was higher than the control group. In the OFT, percentage of time spent in the central area was significantly lower in the immobilization stress-1 and immobilization stress-2 groups. Values of latency to center area, rearing, and grooming did not significantly differ between groups. In the immobilization stress-1 group, zinc was lower, and iron, copper, and manganese were higher than the control group. In the immobilization stress-2 group, copper and manganese were higher, and phosphate was lower than the control group. Our results showed that depression-related behaviors were more dominant in the immobilization stress-1 group. A decrease in the brain zinc level was valid only for the immobilization stress-1 group. These results point to the role of low brain zinc levels in the pathophysiology of depression.Öğe Is alarin really a novel hormone for reproduction?(Wiley, 2019) Gormus, Solak Z., I; Koca, Ozen R.; Solak, H.; Sahin, Z.; Kutlu, S.[Abstract Not Availabe]Öğe Possible Effects of Sertraline on Human Heart Muscle Contractility: An in vitro experimental study(Wiley, 2017) Solak, H.; Gormus, Z. I. Solak; Koca, R. Ozen; Koc, A.; Karaibrahimoglu, A.; Kutlu, S.; Gormus, N.[Abstract Not Availabe]
