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Öğe Chronic immobilization stress induces anxiety-related behaviors and affects brain essential minerals in male rats(Hogrefe Ag-Hogrefe Ag Suisse, 2022) Sahin, Zafer; Ozkurkculer, Alpaslan; Kalkan, Omer Faruk; Ozkaya, Ahmet; Koc, Aynur; Koca, Raviye Ozen; Solak, HaticeAlterations of essential elements in the brain are associated with the pathophysiology of many neuropsychiatric disorders. It is known that chronic/overwhelming stress may cause some anxiety and/or depression. We aimed to investigate the effects of two different chronic immobilization stress protocols on anxiety-related behaviors and brain minerals. Adult male Wistar rats were divided into 3 groups as follows (n = 10/group): control, immobilization stress-1 (45 minutes daily for 7-day) and immobilization stress-2 (45 minutes twice a day for 7-day). Stress-related behaviors were evaluated by open field test and forced swimming test. In the immobilization stress-1 and immobilization stress-2 groups, percentage of time spent in the central area (6.38 +/- 0.41% and 6.28 +/- 1.03% respectively, p < 0.05) and rearing frequency (2.75 +/- 0.41 and 3.85 +/- 0.46, p < 0.01 and p < 0.05, respectively) were lower, latency to center area (49.11 +/- 5.87 s and 44.92 +/- 8.04 s, p < 0.01 and p < 0.01, respectively), were higher than the control group (8.65 +/- 0.49%, 5.37 +/- 0.44 and 15.3 +/- 3.32 s, respectively). In the immobilization stress-1 group, zinc (12.65 +/- 0.1 ppm, p < 0.001), magnesium (170.4 +/- 1.7 ppm, p < 0.005) and phosphate (2.76 +/- 0.1 ppm, p < 0.05) levels were lower than the control group (13.87 +/- 0.16 ppm, 179.31 +/- 1.87 ppm and 3.11 +/- 0.06 ppm, respectively). In the immobilization stress-2 group, magnesium (171.56 +/- 1.87 ppm, p < 0.05), phosphate (2.44 +/- 0.07 ppm, p < 0.001) levels were lower, and manganese (373.68 +/- 5.76 ppb, p < 0.001) and copper (2.79 +/- 0.15 ppm, p < 0.05) levels were higher than the control group (179.31 +/- 1.87 ppm, 3.11 +/- 0.06 ppm, 327.25 +/- 8.35 ppb and 2.45 +/- 0.05 ppm, respectively). Our results indicated that 7-day chronic immobilization stress increased anxiety-related behaviors in both stress groups. Zinc, magnesium, phosphate, copper and manganese levels were affected in the brain.Öğe Chronic Manipulation of Arcuate Kisspeptin Neurons in A1-42 Induced Mouse Model of Alzheimer's Disease(Karger, 2018) Agus, Sami; Eyuboglu, Signem; Solak, Hatice; Bilgin, Volkan Adem; Yavuz, Yavuz; Akkaya, Hatice; Ozge, Baser[Abstract Not Availabe]Öğe Comparison of Fluoxetine and Sertraline in Treatment of Postoperative Depression(Wiley, 2018) Gormus, Z. Isik Solak; Gormus, Niyazi; Solak, Hatice; Koca, Raviye Ozen; Koc, Aynur; Taki, Fatma Nur; Kutlu, Selim[Abstract Not Availabe]Öğe Deneysel depresyon ve antidepresan tedavinin hipotalamik nörogenez ve oreksijenik peptitler üzerine etkisinin araştırılması(Necmettin Erbakan Üniversitesi Sağlık Bilimleri Enstitüsü, 2021) Solak, Hatice; Kutlu, SelimDepresyon, dünya populasyonunun yaklaşık %15’ini etkileyen kronik, tekrarlayan ve hayatı tehdit eden bir hastalıktır. İnsanlardaki yaygın etkisine rağmen depresyon fizyopatolojisi hakkında bilinenler sınırlıdır. Depresyon nörogenezde azalma, dendritik atrofinin artması gibi nöropatolojilerden sorumludur. Antidepresan tedaviler erişkin hipokampal nörogenezi ve nörotrofik faktör ekspresyonunu artırmakta, stresin hipokampal atrofi üzerine olan etkisini düzeltebilmektedir. Bu bilgilere dayanarak kronik hafif stres (KHS) modeli oluşturulmuş sıçanlarda sertralinin depresyon üzerine etkisinin araştırılması ve depresyonun hipotalamustaki hücre proliferasyonu ve hipotalamik peptit düzeylerinin nasıl etkilendiğinin belirlenmesi amaçlanmıştır. Etik Kurul izni alındıktan sonra 56 adet yetişkin erkek Wistar albino sıçan; 1) Kontrol (K), 2) Depresyon (D), 3) Depresyon+ Sertralin (DS) 4) Sertralin (S) gruplarına ayrılmıştır. D ve DS grubuna 15 gün boyunca çeşitli stresörler uygulanmıştır. Hayvanların depresyona girip girmediğini kontrol etmek için 15. gün açık alan testi (AAT) ve zorunlu yüzme testi (ZYT) yapılmıştır. Deneyin 16. günü subkutan olarak ozmotik minipompa yerleştirilmiş ve 15 gün süreyle sertralin (10 mg/kg/gün) uygulanmıştır. Hayvanlarda sertralinin etkinliğini araştırmak amacıyla AAT, yükseltilmiş artı labirent testi (YAT) ve ZYT yapılmıştır. Deneyin sonunda hayvanlar dekapite edilerek hipotalamus dokuları alınmıştır. Tüm sıçanların hipotalamus dokusunda hipotalamik peptit gen ekspresyon seviyeleri kantitatif RT-PZR ile analiz edilmiştir. İstatistiksel değerlendirmelerde ANOVA kullanılarak yapılmıştır. Deneyin başlangıcında ve deney sonundaki hayvan ağırlıkları karşılaştırıldığında D grubunda istatistiksel olarak anlamlı bir azalma gözlemlendi (p<0,01). AAT’de hayvanların katettiği mesafe, hız ve hareket yüzdesi parametrelerinde gruplar arası karşılaştırıldığında S grubunda istatistiksel olarak anlamlı bir artış bulundu (p<0,01), (p<0,05). YAT’de hayvanların açık kolda geçirdiği zaman yüzdesi gruplar arasında istatistiksel olarak anlamlıydı (p<0,01). ZYT’de K ve D oluşturulmuş hayvanların yüzme, tırmanma ve immobil kalma süreleri gruplar arasında karşılaştırıldığında istatistiksel olarak anlamlı fark bulundu (p<0,0001). D grubu diğer gruplara kıyasla en hareketsizken, DS ve S grubunda yüzme davranışında diğer gruplara göre istatistiksel olarak anlamlı bir artış gözlemlendi. Sıçanların hipotalamus dokusundaki gen ekspresyon analizlerinde GLUT2 ve NPY’de D grubunda diğer gruplara kıyasla istatistiksel olarak anlamlı bir azalma gözlemlendi (p<0,05). FGFR2 ve POMC’de D grubunda diğer gruplara göre istatistiksel olarak anlamlı bir artış bulundu (p<0,05). BDNF ve FGF2’de gruplar arasında anlamlı fark görülmedi (p>0,05). Sonuç olarak; Sertralin tedavisinin, KHS tarafından indüklenen depresif benzeri davranışları ve anksiyojenik etkileri iyileştirdiği görülmüştür. Serotoninin hipotalamusta hem nöral öncü hücrelerin oluşumunda hem de yeni üretilen nöronların hayatta kalması üzerinde genel olarak olumlu bir düzenleyici etkiye sahip olduğu sonucuna ulaşılmıştır. Hipotalamustaki yeni oluşmuş nöronların besin alımıyla ilişkili NPY, POMC ve GLUT2 nöronlarını eksprese ettiği gözlenmiştir. Bu durum hipotalamik tanisitlerin enerji metabolizmasının kontrolünde kilit bir rol oynayabileceğini göstermektedir.Öğe Determination of Cardiac Physiological Changes in Experimental Morphine Addiction Model with Rats(Wiley, 2022) Cagliyan, Hande; Gormus, Zulfikare Isik Solak; Solak, Hatice; Koca, Raviye Ozen[Abstract Not Availabe]Öğe Does Fluoksetine Reduce Positive Inotropic Effect of Heart?(Wiley, 2018) Gormus, Z. Isik Solak; Koca, Raviye Ozen; Solak, Hatice; Kutlu, Selim; Gormus, Niyazi[Abstract Not Availabe]Öğe Does Neurokinin 3 Receptor Agonism Affect Hippocampal Neurogenesis in an Experimental Rat Model of Alzheimer's Disease?(Wiley, 2023) Koca, Raviye Ozen; Gormus, Z. Isik Solak; Solak, Hatice; Celik, Fatma Secer; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe Does Phosphodiesterase Inhibiting Agent-Milrinone Prevent Negative Inotropic Effects of Sertraline on Postoperative Human Heart Muscle Contractility? An In Vitro Experimental Study(Wiley, 2017) Gormus, Zulfikare Isik Solak; Koca, Raviye Ozen; Koc, Aynur; Solak, Hatice; Ozdemir, Ayse; Sahin, Zafer; Kutlu, Selim[Abstract Not Availabe]Öğe Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression?(Springer/Plenum Publishers, 2022) Solak, Hatice; Gormus, Z. Isik Solak; Koca, Raviye Ozen; Gunes, Canan Eroglu; Kutlu, SelimDepression is a chronic, recurrent and life-threatening disease affecting approximately 15% of the world population. Depression is responsible for neuropathologies like decreased neurogenesis and increased dendritic atrophy. Antidepressant treatments increase hippocampal neurogenesis and neurotrophic factor expression. Based on this information, it was aimed to investigate effect of sertraline on depression in rats with chronic mild stress (CMS) model and to determine how it affects cell proliferation and hypothalamic peptide levels in hypothalamus. 56 adult male Wistar albino; control, depression(D), depression + sertraline, sertraline were divided into groups. Various stressors were applied to D for 30 days. Open field test (OFT) and forced swimming test (FST) were conducted to check whether the animals were depressed. On the 16th day osmotic minipump was placed subcutaneously and sertraline (10 mg/kg/day) was administered for 15 days. Behavior tests were done. Hypothalamic peptide gene expression levels were analyzed by quantitative RT-PCR. Statistical evaluations were made using ANOVA. It caused a decrease in the percentage of movement in the D and control groups in the OFT, an increase in the immobility time in the D group in the FST, and an increase in the swimming behavior in the DS group. Animals did not show any anxiological behavior based on the elevated plus maze test results. CMS caused a decrease in GLUT2 and NPY gene expression in the hypothalamus of animals, an increase in POMC and FGFR2, and an increase in IGFIR and GLUT2 gene expression in the DS group. Sertraline has been shown to ameliorate the effects of CMS-induced depression. Sertraline is thought to have a positive regulatory effect on both the formation of neural precursor cells and the survival of newly formed neurons in the hypothalamus. Newly formed neurons in the hypothalamus express food intake-related NPY, POMC, GLUT2 neurons, and thus hypothalamic tanycytes may play a key role in the control of energy metabolism.Öğe Effect of Apelin on Anxiety Like Behaviour in Male Rats(Karger, 2021) Sak, Zeynep Caliskan; Kutlu, Selim; Ozkurkculer, Alpaslan; Koca, Raviye Ozen; Solak, Hatice; Gormus, Zisik Solak[Abstract Not Availabe]Öğe Effect of Intravenous Glucose Administration on Catecholamine Concentrations in Hypothalamic Ventromedial Nucleus in Rats: A Microdialysis Study(Wiley-Blackwell, 2016) Solak, Hatice; Koca, Raviye Ozen; Gormus, Z. Isik Solak; Sahin, Zafer; Koc, Aynur; Karaibrahimoglu, Adnan; Kutlu, Selim[Abstract Not Availabe]Öğe Effect of Neurokinin 3 Receptor on Cognitive Behavior and Catecholaminergic System in a Rat Experimental Alzheimer Model(Wiley, 2019) Koca, Raviye Ozen; Solak, Hatice; Gormus, Zulfikare Solak; Kutlu, Selim[Abstract Not Availabe]Öğe The Effect of Phenoxybenzamine to Decreased Heart Muscle Contractility After in vitro Constituted Ischemia(Wiley-Blackwell, 2016) Gormus, Z. Isik Solak; Solak, Hatice; Koca, Raviye Ozen; Sahin, Zafer; Kutlu, Selim; Gormus, Niyazi[Abstract Not Availabe]Öğe Effect of Pregnancy and Lactation Period on Depression Like Behaviour in Depressive Rats(Karger, 2018) Solak, Hatice; Koca, Raviye Ozen; Koc, Aynur; Sahin, Zafer; Uguz, Faruk; Ak, Mehmet; Kurar, Ercan[Abstract Not Availabe]Öğe The Effect of Sertraline on Cognitive Behaviors in Depressed Rats with Chronic Mild Stress Model(Wiley, 2022) Solak, Hatice; Gormus, Z. Isik Solak; Koca, Raviye Ozen; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe The effects of agomelatine, fluoxetine, and sertraline on rat bladder contraction in vitro(Kare Publ, 2023) Gormus, Zulfikare Isik Solak; Vidin, Tuba; Koca, Raviye Ozen; Solak, Hatice; Uslu, Esra FidanObjective: This study aimed to determine the potential effects of three popular antidepressants: agomelatine, fluoxetine, and sertraline on in vitro rat bladder contraction responses, and to investigate their contribution to overactive bladder syndrome. Method: Thirty-two adult male Wistar albino rats, weighing between 300-350 g, were randomly divided into four groups (Control, Agomelatine, Fluoxetine, Sertraline). After cervical dislocation, the bladders were promptly removed, cut into 3-4-millimeter strips, and suspended in an isolated organ bath at a tension of 1 gram. Contractions were induced by acetylcholine (ACh) at a concentration of 10(-5) M. Cumulative doses of agomelatine, fluoxetine, and sertraline (ranging from 10(-8) to 10(-3) M) were administered to the organ bath chambers. The least squares means were compared using the Tukey-Kramer post-hoc test to compare the tension values of the groups at different time points.Results: The inhibition of rat bladder contractions was statistically significant at agomelatine doses of 10(-7) M (p=0.0413), 10(-6) M (p=0.033), 10(-5)M (p=0.003), and 10(-4) M (p<0.001), with a statistically significant recontraction response noticed after the agomelatine dose of 10(-3) M (p<0.001). Cumulative fluoxetine doses at 10(-7) M (p=0.0182), 10(-6) M (p=0.0012), and 10(-5), 10(-4), 10(-3) M (all at p<0.001), along with sertraline doses at 10(-5) M (p=0.0096), 10(-4) M (p=0.001), and 10(-3) M (p<0.001), also significantly inhibited contraction. Conclusion: Agomelatine, fluoxetine, and sertraline were found to exhibit inhibitory effects on bladder contraction in a dose-dependent manner.Öğe The effects of agomelatine, fluoxetine, and sertraline on rat bladder contraction in vitro(Kare Publ, 2023) Gormus, Zulfikare Isik Solak; Vidin, Tuba; Koca, Raviye Ozen; Solak, Hatice; Uslu, Esra FidanObjective: This study aimed to determine the potential effects of three popular antidepressants: agomelatine, fluoxetine, and sertraline on in vitro rat bladder contraction responses, and to investigate their contribution to overactive bladder syndrome. Method: Thirty-two adult male Wistar albino rats, weighing between 300-350 g, were randomly divided into four groups (Control, Agomelatine, Fluoxetine, Sertraline). After cervical dislocation, the bladders were promptly removed, cut into 3-4-millimeter strips, and suspended in an isolated organ bath at a tension of 1 gram. Contractions were induced by acetylcholine (ACh) at a concentration of 10(-5) M. Cumulative doses of agomelatine, fluoxetine, and sertraline (ranging from 10(-8) to 10(-3) M) were administered to the organ bath chambers. The least squares means were compared using the Tukey-Kramer post-hoc test to compare the tension values of the groups at different time points.Results: The inhibition of rat bladder contractions was statistically significant at agomelatine doses of 10(-7) M (p=0.0413), 10(-6) M (p=0.033), 10(-5)M (p=0.003), and 10(-4) M (p<0.001), with a statistically significant recontraction response noticed after the agomelatine dose of 10(-3) M (p<0.001). Cumulative fluoxetine doses at 10(-7) M (p=0.0182), 10(-6) M (p=0.0012), and 10(-5), 10(-4), 10(-3) M (all at p<0.001), along with sertraline doses at 10(-5) M (p=0.0096), 10(-4) M (p=0.001), and 10(-3) M (p<0.001), also significantly inhibited contraction. Conclusion: Agomelatine, fluoxetine, and sertraline were found to exhibit inhibitory effects on bladder contraction in a dose-dependent manner.Öğe Effects of Chronic Modulation of Kiss1 Neurons on Catecholamine Levels in Experimental Alzheimer Disease's Model(Wiley, 2018) Agus, Sami; Eyuboglu, Signem; Solak, Hatice; Bilgin, Volkan Adem; Yavuz, Yavuz; Akkaya, Hatice; Baser, Ozge[Abstract Not Availabe]Öğe Effects of Fluoxetine in Healty and Damaged Rat Aorta(Wiley, 2018) Taki, Fatma Nur; Solak, Hatice; Koca, Raviye Ozen; Ozdengul, Faik; Gormus, Z. Isik Solak; Kutlu, Selim[Abstract Not Availabe]Öğe Effects of Phenoxybenzamine after Hypothermic and Normothermic Ischemia Injury in Rat Aorta(Wiley-Blackwell, 2016) Gormus, Isik Solak; Koca, Raviye Ozen; Solak, Hatice; Sahin, Zafer; Karaibrahimoglu, Adnan; Gormus, Niyazi; Kutlu, Selim[Abstract Not Availabe]
