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Öğe Apoptosis-induced T-cell lymphopenia is related to COVID-19 severity(Wiley, 2021) Cizmecioglu, Ahmet; Cizmecioglu, Hilal Akay; Goktepe, Mevlut Hakan; Emsen, Ayca; Korkmaz, Celalettin; Tasbent, Fatma Esenkaya; Consultant, Fatma ColkesenIncreased levels of acute-phase reactants and lymphopenia are predictors of disease severity in coronavirus disease 2019 (COVID-19). This study aimed to investigate the role of apoptosis in the etiology of lymphopenia in patients with COVID-19. This multicentered, prospective, and case-control study was conducted with polymerase chain reaction (+) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients, and an age-gender-matched control group. Samples were taken at the time of diagnosis and analyzed via flow cytometry within 24 h. The participants' demographic data and initial laboratory tests were also recorded. In total, 33 patients with COVID-19 (mean age = 45.4 +/- 17.2) and 25 controls (mean age = 43.4 +/- 17.4) participated in the study. All patients were identified as having mild (16), moderate (5), or severe (12) disease severity. Both early and late apoptotic cells in B and T lymphocytes were increased in all patients with COVID-19 (p < .05). Early apoptotic (EA) B and T lymphocytes were also higher in severe cases compared to mild cases (p = .026). There was no significant difference between lymphopenia and apoptosis in patients with COVID-19. However, patients with lymphopenia (n = 14) and severe COVID-19 (p = .013) had increased EA T lymphocytes. This study's results show that B and T lymphocytes' apoptosis increases in patients with COVID-19. In addition, enhanced T lymphocyte apoptosis is associated with disease severity in lymphopenic patients with COVID-19.Öğe Comparison of DMSA Scintigraphy and USG in Detecting Renal Cortical Scars in Children with Urinary Tract Infection(Georg Thieme Verlag Kg, 2018) Sahin, Ozlem; Tasbent, Fatma EsenkayaObjective Multiple imaging techniques may be used to evaluate the development of progressive renal damage in children with urinary tract infections (UTIs). The aim of this study was to compare the efficacy of Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy and renal ultrasonography (USG) in detecting renal scars in children with UTIs. Methods A total of 630 kidneys from 364 children were included in the study and the results of DMSA and USG of children with UTIs were evaluated retrospectively between January 2016 and October 2017. DMSA scintigraphy is accepted as the gold standard and it was compared with USG results. Results The sensitivity, specificity, positive predictive value, and negative predictive value for USG in the detection of renal scarring was found as 57.1, 89.6, 40.8, and 94.4%, respectively. Conclusions Although USG is known to be safe, readily available, and relatively inexpensive, the sensitivity of USG does not seem to be sufficient to identify the renal parenchymal damage. We concluded that USG cannot replace DMSA in the evaluation of renal scarring.Öğe Influenza: Epidemiology, Laboratory Diagnosis, and Clinics(Georg Thieme Verlag Kg, 2016) Tasbent, Fatma Esenkaya; Pekcan, SevgiInfluenza is an infectious disease which causes significant morbidity and mortality. Complications of the disease are bronchitis, pneumonia, otitis media, rejection in recipients of transplantation, myocarditis, pericarditis, myositis, glomerulonephritis, and exacerbation of underlying disease such as asthma, chronic obstructive lung disease, and chronic renal failure. Some complications may be seen in high-risk groups. The early diagnosis of the infection and prompt initiation of specific therapy is important for individuals and public health. In this review, we aimed to overview the clinical and epidemiological importance of influenza infections and to give up-to-date information about laboratory diagnosis method.Öğe Investigating Hepatitis C, D and HIV Prevalance in Cases with Positive Hepatitis B Virus Antigen in a Tertiary Hospital and Examining Anti-HDV Positive Cases(Galenos Publ House, 2021) Kurt, Esma Kepenek; Bulut, Rukiyye; Kandemir, Bahar; Erayman, Ibrahim; Bitirgen, Mehmet; Tasbent, Fatma EsenkayaObjectives: Hepatitis B infection has a faster and more progressive course in the presence of hepatitis C virus (HCV), HDV and human immunodeficiency virus (HIV) infections. The aim of this study was to determine anti-HCV, anti-HDV and anti-HIV prevalance in hepatitis B surface antigen (HBsAg) (+) positive patients and to examine patients with positive anti-HDV. Materials and Methods: Data were obtained through scanning hepatitisB patient follow-up files and the hospital automation system. Descriptive data was expressed in numbers and percentages (%). Results: Mean age of 1829 HBsAg positive patients was 42.65 +/- 14.83 (7-95) and 1099 (60.1%) were male and 730 (39.9%) were female. 30 patients (1.64%) had anti-HCV and 28 patients (1.53%) had anti-HDV while 1 patient (0.055%) had positive anti-HIV. The mean age of the patients with positive anti-HDV was 53.16 +/- 15.46 and 12 of these (42.9%) were female and 16 (57.1%) were male. Fifteen HDV positive patients were given peginterferon and 10 patients had relapse and 4 patients had hepatocellular cancer during the follow-up. A patient died due to the quick progression of the disease after deciding upon transplantation. Conclusion: Patients should also be scanned for hepatitis C, D and HIV in the presence of hepatitis B infection and the patient should be followed up and treated accordingly if coinfection is detected.Öğe Investigation of Respiratory Tract Pathogen Human Parechoviruses in Konya, Turkey(Georg Thieme Verlag Kg, 2020) Tokak, Semih; Ozdemir, Mehmet; Tasbent, Fatma EsenkayaObjective This study aims to better understand the epidemiological characteristics of parechoviruses and to determine the genotype distribution in Konya, Turkey. Methods In this study, nasal and throat swab samples taken from 1,110 children who were diagnosed with respiratory tract infection (bronchitis, pneumonia, asthmatic bronchitis, and other respiratory diseases) and applied to various pediatric polyclinics of Meram Medical Faculty Hospital, Necmettin Erbakan University between September 2017 and March 2019 were evaluated. Human parechovirus (HPeV) RNA was investigated by multiplex polymerase chain reaction (PCR) in respiratory tract samples. Specific genotypes of the positive samples were identified by real-time PCR amplification of the VP1 region followed by sequence analysis. Results Of the total of 1,110 samples, 4 were positive for HPeV. Of these, HPeV1 was the most predominant genotype ( n = 3), followed by HPeV4 ( n = 1). HPeV infections were detected throughout the year in Konya, Turkey. Conclusion Although the number of positive samples for HPeV is low, these findings provide information about the genetic diversity and epidemiological of HPeV genotypes circulating in pediatric patients in Turkey. This is the first study to detect prevalence and genotyping of HPeV in respiratory tract infections in Turkey. HPeVs should be considered as causative agents especially in infants with sepsis, meningitis, or encephalitis, and routine testing panels for HPeV detection should be available in hospital laboratories. Further studies using molecular epidemiological methods will be beneficial for identifying genotypes of all HPeVs involved in the etiology and for better monitoring of these infections.Öğe New Index of Journal and Influenza Viruses(Georg Thieme Verlag Kg, 2018) Ozdemir, Mehmet; Tasbent, Fatma Esenkaya[Abstract Not Availabe]Öğe Seroprevalence of hepatitis B in children in Konya region of Turkey(Elsevier Science Bv, 2016) Tasbent, Fatma Esenkaya; Ozdemir, Mehmet; Feyzioglu, Bahadir; Baykan, Mahmut[Abstract Not Availabe]Öğe A Study of the Hepatitis B Frequency and Its Possible Adverse Outcomes on Pregnancy at a University Hospital(Galenos Yayincilik, 2022) Gulseren, Yasemin Derya; Kilic, Fatma; Tasbent, Fatma EsenkayaObjectives: Hepatitis B virus (HBV) is a major global public health problem. Maternal-fetal transmission of viral hepatitis may contribute to pregnancy-related complications. This study aimed to evaluate the frequency of HBV and its possible adverse pregnancy outcomes. Materials and Methods: The study group consisted of patients followed up in the obstetrics service. Pregnancy-related discharge codes were queried approximately 2017-2019. Hepatitis B surface antigen (HBsAg) levels in serum samples were studied by chemiluminescence enzyme immunoassay method (Architect, Abbott Laboratories, USA). The HBsAg-positive group and HBsAg-negative group data were analyzed using SPSS version 22 (SPSS Inc.; Chicago, IL, USA). Results: HBsAg was positive in 255 (2.1 %) patients. Two groups compared in terms of age and there was no significant difference (p=0.45). Two groups compared in terms of pregnancy outcomes and there was no significant difference (p=0.1). Conclusion: The study group consisted of patients with pregnancy complications and HBsAg positivity was found to be 2.1%. A lower rate was found compared to other regions. Studies to be conducted in different endemic regions of Hepatitis B in our country will illuminate the effect of hepatitis B on pregnancy better.Öğe Urogenital Myiasis Caused by Psychoda spp. in Female Patient with No Risk Factor for Myiasis(Ankara Microbiology Soc, 2020) Tasbent, Fatma Esenkaya; Dik, Bilal; Kurt, Esma KepenekMyiasis is defined as follows; some flies lay their eggs and larvae on live organs and tissues or on cavities of nose, eye, ear and etc of humans or animals and the larvae develop there and cause pathological disorders. One of the rare types of myiasis is the urogenital myiasis. This condition has been associated with covering urogenital area with clothes in almost all populations and therefore, less chance for flies to reach this site and lay their eggs. Low socio-cultural level and poor hygiene conditions are stated as the most important risk factors of myiasis. On the other hand, toilets within the human living spaces are ideal environments for fly larvae that are fed on bacteria as they contain moisture and a microbial environment. It is stated that especially in case of the presence of an underlying infection, flies are more prone to lay their eggs or larvae on this area due to the bad smell. In this case report, a patient with a moderate sociocultural level with no underlying chronic disease, no open wound in the genital area and no urinary tract infection was presented. A 53-year-old female patient living with her family in an apartment flat in the city center of Konya admitted to the outpatient clinic of infectious diseases with the complaint of moving worms in her urine. The patient stated that she had seen maggots while urinating for two weeks and that she passed her urine into a container to be sure that the maggots were coming from her urine, upon seeing the maggots there she has admitted to the hospital. The Larvae were defined as the fourth stage larvae of Psychoda spp. No open lesions or wounds were seen in genitourinary area of the patient who had no complaints other than mild urinary burning. Complete blood count test results of the patient were normal and there was no growth in her urine culture. It was stated that other family members whom she lived with did not have similar complaints. The patient was diagnosed as genitourinary myiasis caused byPsychoda spp. and informed about the relationship between hygiene and the disease. And urinary antiseptics were initiated as the treatment for the patient. After the treatment, no larvae were seen in the urine of the patient. In conclusion, many regions are suitable for Psychoda type of adult flies to live in our country due to the climate conditions. It is considered that infestation may develop in patients with less risk factors in terms of urogenital myiasis, that larvae may increase in number of patients who are not treated or followed up and that the infestation may become chronic and results in more serious clinical conditions. The necessary treatment and follow-up must be performed in such cases and the patients should be educated about the relationship between infestation and hygiene.
