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Öğe The association of total sialic acid and malondialdehyde levels with metabolic and anthropometric variables in obesity(Taylor & Francis Ltd, 2015) Yerlikaya, F. H.; Toker, A.; Cicekler, H.; Aribas, A.Serum sialic acid levels are abnormally high in pathological states that exhibit tissue destruction, tissue proliferation or inflammation. We measured total serum sialic acid levels in 139 women and 125 men. Subjects were divided into quartiles according to their body mass index (BMI): Q1 (18-24.9 kg/m(2)), Q2 (25 -29.9 kg/m(2)), Q3 (30 -39.9 kg/m(2)) and Q4 (> 40 kg/m(2)). The patients in Q1 constituted the control group. Serum sialic acid levels of subjects in Q2, Q3 and Q4 were signifi cantly higher than those in Q1. Higher BMI quartiles also were associated with higher levels of serum glucose, insulin, total cholesterol, LDL-cholesterol, triglycerides, high-sensitivity C-reactive protein, malondialdehyde levels, waist circumference, blood pressure and homeostasis model assessment of insulin resistance in both women and men. Lower BMI quartiles were associated with higher levels of serum HDL-cholesterol levels in both women and men. We found positive associations among serum sialic acid levels, BMI and oxidative stress. Serum sialic acid also is related to some conventional cardiovascular risk factors including elevated lipid profile, increased blood pressure, increased serum glucose and insulin levels, and insulin resistance in obese people.Öğe Can YKL-40 be an inflammatory biomarker in vitamin D deficiency?(Wiley-Blackwell, 2016) Can, U.; Uysal, S.; Ugur, A. R.; Toker, A.; Uysaler, A.; Hidayetoglu, B. T.[Abstract Not Availabe]Öğe The effects of forskolin and rolipram on cAMP, cGMP and free fatty acid levels in diet induced obesity(Informa Healthcare, 2014) Doseyici, S.; Mehmetoglu, I.; Toker, A.; Yerlikaya, F. H.; Erbay, E.Obesity is a major health problem. We investigated the effects of forskolin and rolipram in the diet of animals in which obesity had been induced. We used 50 female albino Wistar rats that were assigned randomly into five groups as follows: group 1, control; group 2, high fat diet; group 3, high fat diet + forskolin; group 4, high fat diet + rolipram; and group 5, high fat diet + rolipram + forskolin. The rats were fed for 10 weeks and rolipram and forskolin were administered during last two weeks. The animals were sacrificed and blood samples were obtained. Serum cAMP, cGMP and free fatty acids (FFA) levels were measured using ELISA assays. We also measured weight gain during the 10 week period. cAMP and FFA levels of groups 3, 4 and 5 were significantly higher than those of groups 1 and 2. We found no significant differences in serum cGMP levels among the groups. The weight gain in groups 3, 4 and 5 was significantly less than for group 2. We also found that the weight gain in group 5 was significantly less than in groups 3 and 4. We found that both forskolin and rolipram stimulated lipolysis and inhibited body weight increase by increasing cAMP levels. Also, combination therapy using the two agents may be more effective in preventing diet induced obesity than either agent alone. We found also that these agents did not effect cellular cGMP levels in diet induced obesity.Öğe Inflammatory markers in depressed pregnant women(Oxford Univ Press, 2016) Toy, H.; Turen, E.; Toker, A.; Herguner, S.[Abstract Not Availabe]Öğe The LDL/HDL ratio and atherosclerosis in ankylosing spondylitis(Springer Heidelberg, 2017) Kucuk, A.; Uslu, A. Ugur; Icli, A.; Cure, E.; Arslan, S.; Turkmen, K.; Toker, A.In ankylosing spondylitis (AS) patients, cardiac and vascular involvement may manifest as atherosclerosis and coronary artery disease. Systemic inflammation, oxidative stress, increased low-density lipoprotein (LDL) cholesterol and decreased high-density lipoprotein (HDL) cholesterol constitute a significant risk for atherosclerosis. This study investigated the relationship between carotid intima-media thickness (CIMT), LDL/HDL ratio, total oxidant status (TOS; an indicator of oxidative stress) and ischemic modified albumin (IMA; an ischemic marker in AS patients). Sixty AS patients were diagnosed using the Modified New York Criteria; 54 age- and gender-matched participants were included as controls. CIMT, LDL/HDL ratio, TOS and IMA were measured using the most appropriate methods. IMA was higher in AS patients compared to controls (p < 0.0001). TOS was also increased in AS patients (p = 0.005); as was CIMT (p < 0.0001). The LDL/HDL ratio was also greater in AS patients compared to controls (p = 0.047). A positive correlation was found between CIMT and LDL/HDL ratio among AS patients. Elevated CIMT, IMA and TOS levels suggest an increased risk of atherosclerotic heart disease in AS patients. The LDL/HDL ratio was higher in AS patients compared to controls, and there was a correlation between LDL/HDL ratio and CIMT, albeit statistically weak. Therefore, the LDL/HDL ratio is not a reliable marker to predict atherosclerotic heart disease in AS patients.Öğe Oxidative stress and insulin resistance in policemen working shift(Wiley-Blackwell, 2014) Demir, I.; Toker, A.; Zengin, S.; Laloglu, E.; Aksoy, H.[Abstract Not Availabe]Öğe THE RELATION BETWEEN INFLAMMATION, CAROTID INTIMA-MEDIA THICKNESS AND LOW-DENSITY LIPOPROTEIN CHOLESTEROL-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL RATIO IN ANKYLOSING SPONDYLITIS PATIENTS(Bmj Publishing Group, 2015) Kucuk, A.; Uslu, A. U.; Arslan, S.; Turkmen, K.; Toker, A.; Kayrak, M.[Abstract Not Availabe]Öğe Serum endocan levels in patients with ankylosing spondylitis(Wiley-Blackwell, 2016) Ankarali, S.; Toker, A.; Uysal, S.; Kucuk, A.; Kayrak, M.[Abstract Not Availabe]Öğe Serum homocysteine, arginine, citrulline and asymmetric dimethyl arginine levels, and histopathologic examination of the abdominal aorta in rats exposed to acrylamide(Informa Healthcare, 2013) Toker, A.; Yerlikaya, F. H.; Yener, Y.; Toy, H.We investigated serum homocysteine, arginine, citrulline and asymmetric dimethyl arginine (ADMA) levels and conducted a histopathologic examination of the abdominal aorta in rats given acrylamide (AA) for long periods. We used 25 male and 25 female Wistar rats. Females were divided into three groups; two were experimental groups and one was the control group. Each experimental group consisted of ten animals and each control group consisted of five animals; male animals were divided in the same way. AA, 2 or 5 mg/kg/day, was administered to the experimental groups in drinking water for 90 days. At the end of the experiment, serum samples were analyzed for homocysteine, arginine, citrulline and ADMA using high performance liquid chromatography. Serum homocysteine, citrulline and ADMA levels were significantly higher than controls in both female and male rats when AA was administered at a concentration of 5 mg/kg/day. Serum citrulline levels also were significantly higher than controls when administered AA at a concentration of 2 mg/kg/day in female rats. There was no difference in serum arginine levels among the groups. Histopathologic examination of the abdominal aorta revealed degeneration of the external elastic lamina in rats treated with 5 mg/kg/day AA. Our findings show that long term ingestion of high dose AA with food might contribute to the development of atherosclerosis.Öğe Urinary hydroxyproline levels in prediabetic patients(Wiley-Blackwell, 2014) Kilinc, I.; Uysal, S.; Toker, A.; Gokce, H. R.; Akcay, M.[Abstract Not Availabe]
