Yazar "Topal, Ahmet" seçeneğine göre listele
Listeleniyor 1 - 20 / 32
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Anaesthetic Management with Thromboelastography in a Patient with Glanzmann Thrombasthenia(Aves, 2014) Topal, Ahmet; Kilicaslan, Alper; Erol, Atilla; Cankaya, Baris; Otelcioglu, SerefGlanzmann thrombastenia (GT) is a rare disease of an autosomal recessive inheritance characterized with fatal bleeding tendency. The anaesthesiologist should be cognizant of the risk involved and be prepared with necessary measures. In this paper, we present a GT case of a 9-year-old male with hypospadias, which was successfully repaired after platelet transfusions according to the thromboelastography tracings.Öğe Anesthesia Management in Charcot-Marie-Tooth Disease(2017) Yusifov, Merve; Yılmaz, Resul; Bilge, Ayşegül; Kaya, Ercan; Topal, Ahmet…Öğe Comparison of Hemodynamics Recovery Profile and Costs of Remifentanil Versus Fentanyl-Based Sevoflurane Anesthesia(Ortadogu Ad Pres & Publ Co, 2012) Uluer, Mehmet Selcuk; Topal, Ahmet; Tavlan, Aybars; Erol, Atilla; Kilicaslan, Alper; Otelcioglu, SerefObjective: This trial was designed to compare the effects of fentanyl and remifentanil on hemodynamic parameters, postoperative recovery, sevoflurane consumption and the cost of anesthetics. Material and Methods: Cases that were scheduled to undergo elective laparoscopic cholecystectomy surgery were assigned to two groups with simple random sampling method, as Group F (Fentanyl) and Group R (Remifentanil), each including 30 patients. The anesthetic induction was initiated by administering 1-2 mg/kg propofol bolus based on the bispectral index (BIS) value followed by 2 mu g/kg fentanyl in Group F patients and 1 mu g/kg remifentanil in Group R patients administered in 60 seconds as iv bolus; subsequently, 0.5 mg/kg iv atracurium was administered. For maintenance of anesthesia, 50% oxygen in-air was administered at 4 L/min; the end-tidal sevoflurane concentration was adjusted to achieve a BIS value of 45 to 55. In Group R, remifentanil 0.25 mu g/kg/min infusion was continued. The addition of 0.5 mu g/kg fentanyl was planned as required in Group F. Sevoflurane end-tidal concentration and the changing times were recorded. For each case, the sevoflurane consumption was calculated using the Dion formula. Results: In Group R, the hemodynamic control, particularly the suppression of response to intubation was more successful than in Group F. The eye opening times and Post Anesthesia Care Unit (PACU) transfer times were shorter in Group R relative to Group F (p=0.001 and p=0.001, respectively). Sevoflurane consumption was lower in the Group R (7.18 +/- 3.45 mL) compared to Group F (16.45 +/- 7.15 mL) (p=0.001). The total anesthetic drug cost was similar between the groups. Conclusion: Compared to fentanyl, remifentanil provided a better intraoperative hemodynamic control, faster postoperative recovery and a favorable effect on anesthetic drug cost by decreasing sevoflurane consumption, eliminating the disadvantages of its price.Öğe Comparison of pre-operative platelet functions by thromboelastogram in patients selective serotonin reuptake inhibitors user and non-user(Turkish Assoc Trauma Emergency Surgery, 2022) Yilmaz, Resul; Yusifov, Merve; Hacibeyoglu, Gulcin; Arican, Sule; Topal, AhmetBACKGROUND: The use of antidepressant drugs, in particular selective serotonin reuptake inhibitors (SSRIs), has increased in recent years. Using SSRIs can cause changes in serotonin metabolism. Serotonin provides platelet aggregation and plays a role in the regulation of vascular tone and coagulation processes. The aim of this study was to evaluate the effects of SSRI use on coagulation functions with thromboelastogram (TEG) in patients undergoing surgical operation and to compare with non-user cases. METHODS: The study was designed for 60 patients whose physical status was classified according to the American Society of Anes-thesiology (ASA) classification as ASA I-II were included in the study. During routine pre-operative blood tests, 2 ml complete blood sample used and TEG performed. The cases were divided into two groups as SSRI user and non-user and analyzed. RESULTS: R value was higher in SSRI user patients than in non-user patients. The MA value was significantly lower in SSRI user. There was no statistically significant difference in other parameters. In the evaluation based on duration of SSRI use, there was no statistically significant difference between those whose duration of use was more than 1 year and <1 year. CONCLUSION: When the coagulation process was evaluated by TEG method, it was seen that the onset of clotting was prolonged and thrombus formation was slowed down in SSRI users. The results did not reveal that SSRI alone was the cause of bleeding, but it was concluded that slowing the process might be important, especially for surgical operations.Öğe Comparison of pre-operative platelet functions by thromboelastogram in patients selective serotonin reuptake inhibitors user and non-user(Turkish Assoc Trauma Emergency Surgery, 2022) Yilmaz, Resul; Yusifov, Merve; Hacibeyoglu, Gulcin; Arican, Sule; Topal, AhmetBACKGROUND: The use of antidepressant drugs, in particular selective serotonin reuptake inhibitors (SSRIs), has increased in recent years. Using SSRIs can cause changes in serotonin metabolism. Serotonin provides platelet aggregation and plays a role in the regulation of vascular tone and coagulation processes. The aim of this study was to evaluate the effects of SSRI use on coagulation functions with thromboelastogram (TEG) in patients undergoing surgical operation and to compare with non-user cases. METHODS: The study was designed for 60 patients whose physical status was classified according to the American Society of Anes-thesiology (ASA) classification as ASA I-II were included in the study. During routine pre-operative blood tests, 2 ml complete blood sample used and TEG performed. The cases were divided into two groups as SSRI user and non-user and analyzed. RESULTS: R value was higher in SSRI user patients than in non-user patients. The MA value was significantly lower in SSRI user. There was no statistically significant difference in other parameters. In the evaluation based on duration of SSRI use, there was no statistically significant difference between those whose duration of use was more than 1 year and <1 year. CONCLUSION: When the coagulation process was evaluated by TEG method, it was seen that the onset of clotting was prolonged and thrombus formation was slowed down in SSRI users. The results did not reveal that SSRI alone was the cause of bleeding, but it was concluded that slowing the process might be important, especially for surgical operations.Öğe Comparison of the C-MAC D-Blade, Conventional C-MAC, and Macintosh Laryngoscopes in Simulated Easy and Difficult Airways(Aves, 2014) Kilicaslan, Alper; Topal, Ahmet; Erol, Atilla; Uzun, Sema TuncerObjective: Recently, to further enhance the potential in the management of difficult airways, the highly angulated D-Blade was added to the C-MAC system. The purpose of this study was to investigate the laryngoscopic view and intubation parameters using the new C-MAC D-Blade in comparison to the conventional C-MAC video laryngoscope and Macintosh direct laryngoscope in simulated easy and difficult airways. Methods: We recruited 26 experienced anaesthesia providers into a randomized trial. Each performed tracheal intubation of a Laerdal SimMan r manikin with each laryngoscope in the following laryngoscopy scenarios: (1) normal airway, (2) cervical spine immobilization, and (3) tongue edema. The intubation times, success rates, number of intubation attempts, laryngoscopic views, and severity of dental compression were recorded. Results: In all scenarios, video laryngoscopes provided better laryngeal exposure than the ML and appeared to produce less dental pressure. In the cervical spine immobilization scenario, D-Blade caused less dental pressure and showed better Cormack-Lehane (CL) classes than the other devices (p<0.001). There were no differences between video laryngoscopes in success of tracheal intubation (p>0.05). The CMAC provided the most rapid intubation. The rate of failure was 19% with ML. In the tongue edema scenario, the CMAC provided the most rapid and successful intubation (p<0.001). There were no differences between video laryngoscopes in laryngoscopic views according to CL classification and dental pressure (p>0.05). The rate of failure was 46% with the ML and 7% with the D-Blade. Conclusion: The CMAC D-Blade caused less dental pressure than the conventional C-MAC and ML in the cervical immobilization scenario. The conventional CMAC performed better than the D-Blade and ML in the tongue edema scenario. These two video laryngoscopes may complement each other in various difficult airway situations.Öğe A Comparison of the Effects of Postoperative CPAP and Nasal Oxygen Use on Arterial Blood Gas in Laparoscopic Cholecystectomy Performed in Obese Patients: A Prospective, Randomized Cinical Trial(Ortadogu Ad Pres & Publ Co, 2012) Kiziloz, Sema Peker; Tavlan, Aybars; Topal, Ahmet; Erol, Atilla; Kilicaslan, Alper; Otelcioglu, SerefObjective: This study was designed to compare the effects of continuous positive airway pressure (CPAP) and nasal oxygen use on postoperative blood gases in obese patients undergoing laparoscopic cholecystectomy. Material and Methods: A total of 40 patients with a body mass index (BMI) ranging between 30 and 40 were enrolled in this study. Patients were divided into two groups: Group C (n=20) = CPAP and Group N (n=20) = Nasal O-2. Baseline blood gas was sampled on spontaneous respiration (G(0)). The blood gas sampling was repeated before patients were admitted to the postoperative care unit (PACU) (G(1)). Following the operation, Group C received CPAP 5 cmH(2)O and Group N received 5 1/min O-2 via nasal cannula for 60 minutes. Blood gas sampling was repeated after 60 minutes in both groups (G(2)). Results: At the PACU, the SpO(2) values were higher in Group C relative to Group N at 30 minutes (p<0.05). In both groups, the in-group pH values at G(1) measurement time displayed a statistically significant reduction compared to those at the G(0) measurement time (p<0.05). At G(2), PaCO2 was higher in Group N compared to Group C (p<0.05). In both groups, the in-group PaCO2 values were significantly higher at G(1) relative to G(0) (p<0.01). In Group C, PaO2 was higher at G(2) compared to Group N (p<0.05). Conclusion: Postoperative CPAP use may increase the PaO2 more and provide a better CO2 elimination compared to nasal oxygen use in obese patients undergoing laparoscopic cholecystectomy.Öğe Differences in tip visibility and nerve block parameters between two echogenic needles during a simulation study with inexperienced anesthesia trainees(Springer Japan Kk, 2014) Kilicaslan, Alper; Topal, Ahmet; Tavlan, Aybars; Erol, Atilla; Otelcioglu, SerefNeedle tip visualization during ultrasound-guided regional anesthesia (UGRA) is necessary for safety and efficacy. However, disruption of the image of the needle tip driven toward the target is a general problem, especially for beginners. The purpose of this study was to compare performance parameters between using the Sonoplex and Stimuplex D-Plus echogenic needles in a simulated ultrasound-guided interventional task by inexperienced anaesthesia residents. After a standardized training session, 28 anesthesiology residents performed simulated nerve blocks in a beef phantom with each needle. All ultrasound images were digitally stored for analysis. The absolute time the needle tip was in view, total procedure time, and angle of needle insertion were subsequently measured objectively by two single investigators. The procedures that used the Sonoplex echogenic needle had significantly better tip visibility and shorter total procedure time at insertion angles between 42A degrees and 64A degrees relative to the phantom surface. We have demonstrated that inexperienced users who used the Sonoplex echogenic needle were able to complete the procedure more quickly. Needles with improved visibility would be a very useful addition to UGRA for inexperienced users.Öğe Diyabetik Vakalarda Roküronyumun Nöromusküler Blok Özellikleri(2014) Topal, Ahmet; Sargın, Mehmet; Et, Tayfun; Tuncer Uzun, SemaAmaç: Diyabetik hastalarda motor sinir liflerinde fonksiyonel kayıplar ortaya çıkmakta ve bu durum anestezi yönetimini birçok yönden etkileyebilmektedir. Bu çalışmada roküronyumun nöromusküler blok etkilerinin non-diyabetik hastalara göre tip II diyabetli hastalarda farklı olup olmadığını araştırmayı amaçladık. Materyal ve Metod: 18 diyabetik ve 21 non-diyabetik hastanın, 0,6 mg kg-1 roküronyum uygulanmasından sonra nöromüsküler transport monitörü kullanılarak nöromusküler fonksiyonları değerlendirildi.Etki başlama süresi, klinik etki süresi, derlenme süresi, toplam roküronyum dozu, supramaksimal uyarı şiddeti ve Goldberg entübasyon skoru karşılaştırıldı. Bulgular: Etki başlama (118,3341,61 sn. & 142,0028,68 sn.) ve derlenme (13,339,83 dak. & 22,3811,64 dak.) süreleri diyabetik hastalarda daha uzundu (p0,05), etki süresi ve supramaksimal uyarı şiddeti benzerdi (p0,05). Sonuç: Diyabetik hastalarda etki başlama ve derlenme sürelerinde görülen uzamanın, diyabete bağlı gelişen nöropatik bir komplikasyon olduğunu ve roküronyumun farmakodinamiğinde diyabetin etkili olduğunu düşünmekteyiz.Öğe The Effect of Sevoflurane and Desflurane on the Early Postoperative Cognitive Functions in Geriatric Patients(2013) Tavlan, Aybars; Topal, Ahmet; Kılıçaslan, Alper; Erol, Atilla; Çobanoğlu, Halit; Otelcioğlu, ŞerefOur aim was to compare the effects of desflurane and sevoflurane on cognitive functions of geriatric patients that were planned for elective surgery under general anestesia. After national ethical committee approval, 40 patients (aged 65-75 yr) were enrolled. Patients were allocated to either the desflurane (n20) or the sevoflurane (n20) group. In all patients anaesthesia will be induced with propofol and remifentanyl, and maintained with the anaesthetics desflurane, or sevoflurane, and remifentanyl. Emergence times from anaesthesia and Aldrete scores were recorded. Cognitive function will be evaluated with two cognitive test; Blessed Short Orientation Memory Concentration Test (BOMC) and standardized mini mental test (SMMT) preoperatively and postoperatively at 60, and 180 minute after extubation. The mean extubation time, eye opening time and Aldrete scores were similar in the desflurane and sevoflurane groups (p0,05). There were no significant differences between the desflurane and the sevoflurane groups when the BOMC and MMST scores were compared preoperatively, and postoperatively at 60, and 180 min (p0,05).The result of this study indicate that there is no difference between effects of desflurane and sevoflurane anesthesia on postoperatif cognitive functions in the elderly.Öğe The Effect of Sevoflurane and Desflurane on the Early Postoperative Cognitive Functions In Geriatric Patients(Modestum Ltd, 2013) Cobanoglu, Halit; Tavlan, Aybars; Topal, Ahmet; Kilicaslan, Alper; Erol, Atilla; Otelcioglu, SerefOur aim was to compare the effects of desflurane and sevoflurane on cognitive functions of geriatric patients that were planned for elective surgery under general anestesia. After national ethical committee approval, 40 patients (aged 65-75 yr) were enrolled. Patients were allocated to either the desflurane (n= 20) or the sevoflurane (n= 20) group. In all patients anaesthesia will be induced with propofol and remifentanyl, and maintained with the anaesthetics desflurane, or sevoflurane, and remifentanyl. Emergence times from anaesthesia and Aldrete scores were recorded. Cognitive function will be evaluated with two cognitive test; Blessed Short Orientation Memory Concentration Test (BOMC) and standardized mini mental test (SMMT) preoperatively and postoperatively at 60, and 180 minute after extubation. The mean extubation time, eye opening time and Aldrete scores were similar in the desflurane and sevoflurane groups (p> 0,05). There were no significant differences between the desflurane and the sevoflurane groups when the BOMC and MMST scores were compared preoperatively, and postoperatively at 60, and 180 min (p> 0,05). The result of this study indicate that there is no difference between effects of desflurane and sevoflurane anesthesia on postoperatif cognitive functions in the elderly.Öğe The Effect of Transversus Abdominis Plane Block in Inguinal Hernioplasty on Chronic Pain(Modestum Ltd, 2015) Topal, Ahmet; Sargin, Mehmet; Kilicaslan, Alper; Uzun, Sema TuncerThe aim of the current study was to retrospectively evaluate the efficacy of IV analgesia after general anesthesia, transversus abdominis plane (TAP) block after the induction of general anesthesia and before the surgery and spinal analgesia on development of chronic pain following inguinal hernia repair. Forty patients, who underwent hernioplasty for the first-time and for whom at least 6 months had passed since the operation date were included in the study, were included in each group as follows: Group G received IV analgesia with general anesthesia; Group T included patients who received TAP block with general anesthesia; and Group S received spinal anesthesia. The study evaluated early and chronic postoperative pain, as well as pain severity, nature of the pain, predisposing factors, and the effect on various activities. No difference was found in pain incidence among the groups in the early postoperative pain evaluation; whereas VAS scores were lower in Group T. Chronic pain incidence was found to be lower in Group T. However, there was no difference among the groups in terms of VAS scores, pain nature, frequency, its effect on daily activities and sleep for patients with chronic pain. The TAP block is an effective method to prevent chronic pain development after inguinal hernioplasty compared to the other two methods. Because of the retrospective nature of the study, further prospective clinical trials are required.Öğe The Effect of Transversus Abdominis Plane Block in Inguinal Hernioplasty on Chronic Pain(Modestum Ltd, 2015) Topal, Ahmet; Sargin, Mehmet; Kilicaslan, Alper; Uzun, Sema TuncerThe aim of the current study was to retrospectively evaluate the efficacy of IV analgesia after general anesthesia, transversus abdominis plane (TAP) block after the induction of general anesthesia and before the surgery and spinal analgesia on development of chronic pain following inguinal hernia repair. Forty patients, who underwent hernioplasty for the first-time and for whom at least 6 months had passed since the operation date were included in the study, were included in each group as follows: Group G received IV analgesia with general anesthesia; Group T included patients who received TAP block with general anesthesia; and Group S received spinal anesthesia. The study evaluated early and chronic postoperative pain, as well as pain severity, nature of the pain, predisposing factors, and the effect on various activities. No difference was found in pain incidence among the groups in the early postoperative pain evaluation; whereas VAS scores were lower in Group T. Chronic pain incidence was found to be lower in Group T. However, there was no difference among the groups in terms of VAS scores, pain nature, frequency, its effect on daily activities and sleep for patients with chronic pain. The TAP block is an effective method to prevent chronic pain development after inguinal hernioplasty compared to the other two methods. Because of the retrospective nature of the study, further prospective clinical trials are required.Öğe Effectiveness of videolaringoscopy C-MAC in managing intubations that have failed unexpectedly(Elsevier Science Inc, 2014) Kilicaslan, Alper; Topal, Ahmet; Tavlan, Aybars; Erol, Atilla; Otelcioglu, Seref[Abstract Not Availabe]Öğe The Effects of Sugammadex on Progesterone Levels in Pregnant Rats(2015) Et, Tayfun; Topal, Ahmet; Erol, Atilla; Tavlan, Aybars; Kılıçaslan, Alper; Tuncer Uzun, SemaBackground: Sugammadex has been shown to de- crease the efficiency of progesterone-containing oral contraceptive drugs which possess a steroid structure. Aims: The aim of the present study was to evaluate the effects of sugammadex on progesterone levels in pregnant rats as well as on the physiological course of the pregnancy. Study Design: Animal experiment. Methods: This study was approved by the Selçuk Uni- versity Ethical Committee for Experimental Animal Research. Pregnant Winster Albino rats (n26) were divided into three groups and administered with vari- ous intravenous injections on the 7th day of pregnancy. The control group (Group K, n6) received 1.5 mL serum physiologic, the sugammadex group (Group S, n10) received 30 mg/kg sugammadex and the sugam- madex rocuronium group (Group SR, n10) received 30 mg/kg sugammadex and 3.5 mg/kg rocuronium. Progesterone levels were measured and the offspring were monitored for morphologic status. Results: Mean progesterone levels were 94.16±15.54 ng/mL in Group K, 87.86±12.48 ng/mL in Group S, and 94.53±16.10 ng/mL in Group SR (p<0.05). No stillbirth or miscarriage was observed in the rats. The mean number of offspring was 6.8±1.47 in Group K, 6.5±1.35 in Group S, and 6.4±1.17 in Group SR. The offspring appeared macroscopically normal. Conclusion: Sugammadex does not appear to affect the progesterone levels in pregnant rats in the first trimes- ter and the clinical course. Successful completion of pregnancy and the absence of stillbirth or miscarriage will guide future studies about the use of sugammadex, particularly in the first trimester of the pregnancy.Öğe Evaluation of coagulation with TEG in patients diagnosed COVID-19(Tubitak Scientific & Technological Research Council Turkey, 2022) Vatansev, Hulya; Karaselek, Mehmet Ali; Yilmaz, Resul; Kuccukturk, Serkan; Topal, Ahmet; Yosunkaya, Sebnem; Kucuk, AdemBackground and aim: A high D-dimer level may indicate the risk of coagulopathy and mortality in COVID-19 patients. Thromboelastography (TEG) is a test that evaluates clot formation and fibrinolysis in real-time, unlike routine coagulation tests. The study aimed to investigate the coagulation process with TEG in patients diagnosed with COVID-19. Materials and Methods: The study was performed at our university hospital, chest diseases outpatient clinic as a cross-section study. A total of 51 patients with 23 high D-dimer levels group (HDG) and 28 low D-dimers group (LDG) were included in the study. TEG analysis was performed at the pretreatment evaluation in these two groups. Results: D-dimer and fibrinogen levels of the HDG were higher than those of the LDG (550 vs. 90 ng/mL, p < 0.001; 521 vs. 269 mg/ dL, p < 0.001, respectively). In TEG analysis, HDG's R and K values were lower than LDG, and HDG's Angle, MA, and CI values were higher than LDG (p = 0.037; p < 0.001; p < 0.001; p < 0.001; p < 0.001, respectively). ROC curve analysis suggested that the optimum TEG parameters cut-off points for thrombosis risk were as below: for K was <_2.1 min, for R was <_6.1 min, for Angle was >62 degrees, MA was 60.4 mm. Conclusion: Our study showed that the risk of thrombosis might increase in COVID-19 patients who are not hospitalized in the intensive care unit. Thrombosis risk should be investigated with TEG analysis and laboratory tests in every patient diagnosed with COVID-19, and treatment should be started for risky patients.Öğe Fulminant Liver Failure Due to Amanita Phalloides Toxicity Treated with Emergent Liver Transplantation(Modestum Ltd, 2015) Gok, Funda; Topal, Ahmet; Hacibeyoglu, Gulcin; Erol, Atilla; Biyik, Murat; Kucukkartallar, Tevfik; Yosunkaya, AlperThe clinical picture secondary to amanita phalloides, which began with gastrointestinal complaints, advanced to fulminant hepatic failure in two days. Emergency liver transplantation was decided for the case of a 48-year-old male patient, who at the same time had renal failure and acute pancreatitis. Bridge treatment with plasma diafiltration was applied until the liver transplantation, which was successfully performed on the fifth day of admission to the hospital. Acute pancreatitis and renal failure also resolved and the patient was discharged in a healthy condition on the 30th day of admission. The timing of the transplant in fulminant liver failure and criteria used to select the timing are particularly important. Transplantation should be performed not too early, nor too late. In addition, the development of multiple organ failure during the period until transplantation may result in the death of the patient. Therefore, extra corporeal liver support systems are suggested as an important treatment tool at this stage.Öğe Fulminant Liver Failure Due to Amanita Phalloides Toxicity Treated with Emergent Liver Transplantation(Modestum Ltd, 2015) Gok, Funda; Topal, Ahmet; Hacibeyoglu, Gulcin; Erol, Atilla; Biyik, Murat; Kucukkartallar, Tevfik; Yosunkaya, AlperThe clinical picture secondary to amanita phalloides, which began with gastrointestinal complaints, advanced to fulminant hepatic failure in two days. Emergency liver transplantation was decided for the case of a 48-year-old male patient, who at the same time had renal failure and acute pancreatitis. Bridge treatment with plasma diafiltration was applied until the liver transplantation, which was successfully performed on the fifth day of admission to the hospital. Acute pancreatitis and renal failure also resolved and the patient was discharged in a healthy condition on the 30th day of admission. The timing of the transplant in fulminant liver failure and criteria used to select the timing are particularly important. Transplantation should be performed not too early, nor too late. In addition, the development of multiple organ failure during the period until transplantation may result in the death of the patient. Therefore, extra corporeal liver support systems are suggested as an important treatment tool at this stage.Öğe Glanzmann Trombastenili Olguda Tromboelastografi Eşliğinde Anestezi Yönetimi(2014) Topal, Ahmet; Kılıçaslan, Alper; Erol, Atilla; Çankaya, Barış; Otelcioğlu, ŞerefGlanzmann trombastenisi (GT) ölümcül kanamalara yol açabilen, nadir görülen otozomal resesif geçişli bir hastalıktır. Anestezistler bu kanama riskinin farkında olmalı ve gerekli önlemleri almalıdırlar. Bu yazıda, tromboelastografi traseleri rehberliğinde trombosit transfüzyonu sonrası başarılı hipospadias tamiri yapılan 9 yaşındaki GT tanılı erkek olgu sunulmuştur.Öğe Halotan, izofluran ve sevofluranın anestezi cihazı ortamında psodomonas aeruginosa, staphylococcus aureus ve escherichia colinin üreme hızlarına etkileri(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 2002) Topal, Ahmet; Duman, AteşAnestezi cihazlarında kullanılan maske, konnektör, hortum ve nemli solunum devreleri, enfeksiyon ve kontaminasyon için iyi bir ortam sağlarlar. Ancak klinik uygulama sırasında kontaminasyon beklendiği kadar sık görülmemektedir. Volatil anesteziklerle anestetize edilen hastalarda postoperatif pulmoner enfeksiyon beklenenden daha az ortaya çıkmaktadır. Bu durum, "volatil anesteziklerin antibakteriyel etkileri olabilir mi?" sorusunu akla getirmektedir. Bu çalışmada, volatil anesteziklerden halotan, izofluran ve sevofluranın, P. aeruginosa, S. aureus ve E. Coli'nin üreme hızı üzerine, anestezi cihazı ortamında, in vitro şartlarda, etkilerini araştırmayı amaçladık. Buyyon içindeki P. aeruginosa, S. aureus ve E. colfnin, spektrofotometrede 450 nu. dalga boyunda ışık kırıcılığı okunup giriş değeri olarak kayıt edildi. Mikroorganizmalar, anestezi cihazında, %50 oksijenli ortamda, halotan, izofluran ve sevoflurana, bir, iki, üç ve dört saat süreyle, 1 MAC ve 2 MAC'da üçer defa maruz bırakıldı. Sürelerin sonunda tekrar mikroorganizmaların ışık kırıcılığı okunup çıkış değeri olarak kayıt edildi. Kontrol grubu için, P. aeruginosa, S. aureus ve E. coli, buyyon içinde, %50 oksijen konsantrasyonunda, bir, iki, üç ve dört saat süreyle, anestezi cihazı ortamında, üremesi için bekletildi. Bu deneyde üç kez tekrarlandı. Girişte ve süre sonlarında spektrofotometrede ışık kırıcılığı okundu ve giriş, çıkış değerleri olarak kayıt edildi. Bulunan giriş ve çıkış değerlerinin yüzde değişimleri hesaplanarak kontrol grubu yüzde değişim değerleri ile istatistiksel olarak karşılaştırıldı. İstatistiksel yöntem olarak tek yönlü varyans analizi ve tukey HSD testi kullanıldı, p <0.05 değerleri anlamlı kabul edildi. Halotan, izofluran ve sevofluranın, 1 MAC ve 2 MAC'da, bir saat, iki saat, üç saat ve dört saat sürelerde, anestezi cihazı ortamında P. aeruginosa, S. aureus ve E. coli suşlarmın üreme hızları üzerine inhibe edici etkileri gösterildi. Bakteri üreme hızını baskılayıcı etki, halotan ve sevofluranda fazla iken, izofluranda bu etki halotan ve sevoflurana göre daha azdı. Volatil anesteziklerin bakteri üreme hızını baskılayıcı etkilerine en duyarlı mikroorganizma, P. aeruginosa ve E. coli idi. S. aureus ise bu etkiye en dirençli mikroorganizma idi.
