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    Association of Reactive-Proactive Aggression and Anxiety Sensitivity with Internalizing and Externalizing Symptoms in Children with Attention-Deficit/Hyperactivity Disorder
    (Springer, 2017) Bilgic, Ayhan; Tufan, Ali Evren; Yilmaz, Savas; Ozcan, Ozlem; Ozmen, Sevgi; Oztop, Didem; Turkoglu, Serhat
    This study evaluates the associations among the symptoms of anxiety, depression, and disruptive behavioral disorders (DBD) in the context of their relationships with reactive-proactive aggression and anxiety sensitivity in children with attention-deficit/hyperactivity disorder (ADHD). The sample consisted of 342 treatment-naive children with ADHD. The severity of ADHD and DBD symptoms were assessed via parent-and teacher-rated inventories. Anxiety sensitivity, reactive-proactive aggression and severity of anxiety and depression symp-toms of children were evaluated by self-report inventories. According to structural equation modeling, depression and anxiety scores had a relation with the DBD scores through reactive-proactive aggression. Results also showed a negative relation of the total scores of anxiety sensitivity on DBD scores, while conduct disorder scores had a positive relation with anxiety scores. This study suggests that examining the relations of reactive-proactive aggression and anxiety sensitivity with internalizing and externalizing disorders could be useful for understanding the link among these disorders in ADHD.
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    Effect of Impairment on the Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder in a National Survey: Nation-Wide Prevalence and Comorbidities of ADHD
    (Sage Publications Inc, 2022) Ercan, Eyup Sabri; Unsel-Bolat, Gul; Tufan, Ali Evren; Karakoc Demirkaya, Sevcan; Bilac, Oznur; Celik, Goncagul; Kilic, Birim Gunay
    Objective: This study aimed to determine the prevalence and comorbidities of attention-deficit hyperactivity disorder (ADHD) by evaluating a large-scale nation-wide sample of children. Method: The inclusion criterion was being enrolled as a 2nd, 3rd, or 4th-grade student. A semi-structured diagnostic interview (K-SADS-PL), DSM-IV-Based Screening Scale for Disruptive Behavior Disorders, and assessment of impairment (by both parents and teachers) were applied to 5,842 participants. Results: The prevalence of ADHD was 19.5% without impairment and 12.4% with impairment. Both ADHD with and without impairment groups had similar psychiatric comorbidity rates except for oppositional defiant disorder (ODD) and conduct disorder (CD) diagnoses. Impairment in the ADHD group resulted in significantly higher ODD and CD diagnoses. Conclusion: Even when impairment is not described, other psychiatric disorders accompany the diagnosis of ADHD and may cause impairment in the future. Impairment in the diagnosis of ADHD significantly increases the likelihood of ODD and CD.
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    The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T)
    (Taylor & Francis Ltd, 2019) Ercan, Eyup Sabri; Polanczyk, Guilherme; Ardic, Ulku Akyol; Yuce, Deniz; Karacetin, Gul; Tufan, Ali Evren; Tural, Umit
    Aim: The aim of this study was to determine the prevalence of childhood psychopathologies in Turkey. Method: A nation-wide, randomly selected, representative population of 5830 children (6-13 years-old) enrolled as a 2nd,3rd or 4th grade student in 30 cities were evaluated for presence of a psychiatric or mental disorder by a Sociodemographic Form, Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), and DSM-IV-Based Screening Scale for Disruptive Behavior Disorders in Children and Adolescents scales. Impairment criterion was assessed via a 3 point-Likert scale by the parent and the teacher independently. Results: Overall prevalence of any psychopathology was 37.6% without impairment criterion, and 17.1% with impairment criterion. Attention-deficit hyperactivity disorder was the most frequent diagnosis, followed by anxiety (19.5% and 16.7% without impairment, 12.4% and 5.3% with impairment, respectively). Lower education level and presence of a physical or psychiatric problem of the parents were independent predictors of any psychopathology of the offspring. Conclusion: This is the largest and most comprehensive epidemiological study to determine the prevalence of psychopathologies in children and adolescents in Turkey. Our results partly higher than, and partly comparable to previous national and international studies. It also contributes to the literature by determining the independent predictors of psychopathologies in this age group.
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    Relationship between anxiety, anxiety sensitivity and conduct disorder symptoms in children and adolescents with attention-deficit/hyperactivity disorder (ADHD)
    (Springer, 2013) Bilgic, Ayhan; Turkoglu, Serhat; Ozcan, Ozlem; Tufan, Ali Evren; Yilmaz, Savas; Yuksel, Tugba
    [Abstract Not Availabe]
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    The Relationship Between Parental Affective Temperament Traits and Disruptive Behavior Disorders Symptoms in Children With ADHD
    (Sage Publications Inc, 2018) Bilgic, Ayhan; Yilmaz, Savas; Ozcan, Ozlem; Tufan, Ali Evren; Ozmen, Sevgi; Oztop, Didem; Akca, Omer Faruk
    Objective: This study investigated the relationship between parental affective temperaments and the oppositional defiant disorder (ODD) and conduct disorder (CD) symptoms of children with ADHD. Method: The sample consisted of 542 treatment-naive children with ADHD and their biological parents. Children were assessed via both parent- and teacher-rated behavioral disorder scales. Parental affective temperament and ADHD symptoms were measured by self-report inventories. The relationships between psychiatric variables were evaluated using structural equation modeling. Results: According to parent-rated behavioral disorder scales, paternal cyclothymic and maternal irritable temperaments were associated with ODD scores, and maternal depressive temperament was associated with CD scores. In terms of teacher-rated behavioral disorder scales, maternal anxious temperament was associated with ODD scores, and paternal cyclothymic and maternal depressive temperaments were associated with CD scores. Conclusion: These results suggest that certain parental affective temperaments are related to an increase in symptoms of disruptive behavioral disorders in children with ADHD.
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    Tardive Dyskinesia Due to Olanzapine in an Adolescent with Psychosis and its Treatment with Clozapine
    (Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2013) Tufan, Ali Evren; Bilici, Rabia; Ugurlu, Gorkem Karakas; Yilmaz, Savas; Erdogan, Ayten
    Atypical antipsychotics are increasingly being used in the current clinical approach for the treatment of various psychopathologies in children and adolescents. The common use of atypical antipsychotics in this age group may lead to various consequences, including movement disorders, such as tardive dyskinesia (TD). In this study, we aimed to present the diagnosis of TD due to long-term use of olanzapine and successful treatment with clozapine in an adolescent patient who has been followed with the diagnoses of moderate mental retardation and undifferentiated schizophrenia. It may be posited that female adolescents with chronic illnesses, receiving long-term antipsychotic medication, with affective and negative symptoms, mental retardation, and teeth infections should be monitored regularly for TD. Clozapine may be a choice in the treatment of tardive dyskinesia developing in adolescent patients. Considering the increase in long-term use of atypical antipsychotics in children and adolescents for various indications, it can be though that further studies on the phenomenology, diagnosis and methods of treatment of TD in those patients are required.