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    COMPARISON OF CARDIAC ARRHYTHMIA TYPES BETWEEN HYPERTHYROID PATIENTS WITH GRAVES' DISEASE AND TOXIC NODULAR GOITER
    (Editura Acad Romane, 2018) Turan, E.; Can, I.; Turan, Y.; Uyar, M.; Cakir, M.
    Purpose. Previous studies have demonstrated the relationship between hyperthyroidism and increased risk of cardiac arrhythmias. The most common causes of hyperthyroidism are Graves' disease (GD) and toxic nodular goiter (TNG). The aim of our study was to demonstrate if the underlying mechanism of hyperthyroidism, in other words autoimmunity, has an impact on the type of cardiac arrhythmias accompanying hyperthyroidism. Method. Twenty patients with TNG and 16 patients with GD who had overt hyperthyroidism were included in the study. Age, sex, thyroid hormone levels, thyroid autoantibody positivity, thyroid ultrasonography and scintigraphy results were recorded. 24-hour Holter ECG monitoring was performed in all patients. Results. Mean age was significantly higher in the TNG group compared to the GD group (62.9 +/- 11.5 vs. 48.9 +/- 8.6 years, p=0.001). Free T3 was significantly higher (7.87 +/- 3.90 vs. 5.21 +/- 1.53 pg/mL, p=0.033) in the GD group while free T4 and TSH levels were similar between the two groups. In 24-hour Holter ECG recordings nonsustained ventricular tachycardia (VT) rates were significantly higher in the GD group than in TNG group [18.75% (n=3/16) vs. 0% (n=0/20), respectively, (p=0.043)] Paroxysmal atrial fibrillation (AF) rates were significantly higher in the TNG group compared to GD group [(30% (n=6/20) vs. 0% (n=0/16), respectively, (p=0.016)]. Conclusion. Although free T3 levels were lower, paroxysmal AF rates were found significantly higher in the TNG group which may be associated with significantly higher age of this group. On the other hand, higher rate of nonsustained VT in the GD group may be related to either significantly higher free T3 levels or autoimmunity.
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    NORMOCORTISOLEMIA AFTER TEN DAYS OCTREOTIDE TREATMENT IN A PATIENT WITH ECTOPIC CUSHING'S SYNDROME DUE TO BRONCHIAL CARCINOID
    (Editura Acad Romane, 2013) Kaya, A.; Cakir, M.; Turan, E.; Kulaksizoglu, M.; Tastekin, G.; Altinok, T.
    Contex. We report the use of subcutaneous somatostatin injection three times a day to decrease hypercortisolism in a patient who had Cushing's syndrome induced by bronchial carcinoid tumour progressive pneumonia due to immune suppression. Subject and Method. A 46-year-old man with 7-month history of DM type-2, hypertension and cerebrovascular-disease, vertebral compression-fracture was admitted to our clinic. Physical examination was consistent with Cushing's syndrome. Laboratory results revealed hyperglycemia (143 mg/dL; reference range, <100 mg/dL) and hypokalemia (2.29 mEq/L; reference range, 3.5-5.1 mEq/L). His morning serum cortisol was 40 mu g/dL (reference range 6.7-22.6 mu g/dL), urine cortisol-excretion was 2245 mu g/24 hours (reference range 58-403 mu g/24 hours), after 1 mg dexamethasone-suppression test serum cortisol was 28 mu g/dL (6.7-22.6 mu g/dL) and ACTH 354 pg/mL (reference range 7.9-66 pg/mL). Adrenal CT and hypophyseal MRI were normal. An ectopic source was searched for Cushing's syndrome. Chest CT scan of the right lung showed 12x9 mm nodule. High fever cough occurred on the follow-up. Chest radiograph revealed diffuse pneumonic infiltration. Despite 3-drug antibiotic combination therapy, infection did not improve. Subcutaneous injection of octreotide 3x100 mu g was initiated to decrease hypercortisolism. The infection improved rapidly after the therapy. The morning serum cortisol, urine cortisol-excretion, ACTH was at the upper normal range (77.1 pg/mL, reference range 7.9-66 pg/mL) on 10th day of treatment. The patient was a consulted for surgery and the nodule was excised. The pathology was consistent carcinoid tumor. Conclusion. Subcutaneous octreotide treatment may be helpful to gain time for exploring the focus in ectopic cushing's syndrome and to control the serious infections due to hypercortisolism.
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    Structural and optical investigation of spray-deposited SnO2 thin films
    (Springer, 2022) Turan, E.; Kul, M.; Akin, S.
    A study of the investigation of tin oxide (SnO2) thin films deposited by spray pyrolysis method was undertaken by analysing the structural and optical properties for different substrate temperatures. X-ray diffraction patterns have revealed that the formation of tetragonal tin oxide nanoparticles was observed and the crystallite size, strain and dislocation density of the samples vary with the substrate temperature. In addition, X-ray photoelectron spectroscopy was used to obtain the composition and electronic structure. From morphological characterization, it is clear that the thin films are uniform without cracks with dense morphology consisting homogenous distribution of crystallites in nanometer dimension. Analysis on optical properties revealed that the direct optical band gap of the SnO2 films lies between 3.88 and 3.98 eV up to the substrate temperature of 450 degrees C, and it showed a remarkable decrease to 3.73 eV for 500 degrees C. The envelope method analysis based on the use of the maxima and minima of the interference fringes has been used to define the complex index of refraction and the extinction coefficient. Photoluminescence characteristics of the SnO2 thin films were investigated at room temperature. The all photoluminescence spectra have exhibited six luminescence centres ascribed to the presence of intrinsic defects such as oxygen vacancies and structural defects in the SnO2. Two of them are for room-temperature radiative recombinations of band-acceptor and donor-acceptor pairs observed at 420 and 451 nm, respectively. All of the results have been appreciated for optoelectronic and sensor devices.