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Öğe The Association Between Peri-aortic Fat and Long-term Incidence of Major Adverse Cardiovascular Events(Elsevier Science Inc, 2013) Kaya, Zeynettin; Ulucan, Seref; Katlandur, Huseyin; Keser, Ahmet; Tuncez, Abdullah; Alihanoglu, Yusuf Izzettin; Efe, Duran[Abstract Not Availabe]Öğe The association between thoracic periaortic fat and major adverse cardiovascular events(Springer Wien, 2015) Kaya, Zeynettin; Ulucan, Seref; Kayrak, Mehmet; Akyurek, Omer; Katlandur, Huseyin; Keser, Ahmet; Efe, DuranThe study aimed to examine the association between thoracic periaortic fat tissue volume and the long-term incidence of major adverse cardiovascular events. This retrospective cohort study included 433 consecutive patients (372 male and 61 female). Periaortic fat tissue volume was measured via electrocardiogram-gated 64-multidetector computed tomography. The patients were evaluated on an average 3 years of follow-up for major adverse cardiovascular events. The patients were divided into groups according to the presence of major adverse cardiovascular events. Major adverse cardiovascular events were noted in 44 (10.2 %) patients during follow-up. Periaortic fat tissue volume was significantly higher in the major adverse cardiovascular events (+) group (35.4 +/- A 26.1 cm(3) vs. 24.1 +/- A 14.9 cm(3), P = 0.001). The logistic regression model showed that periaortic fat tissue volume (hazard ratio: 1.03; 95 % CI: 1.01-1.05; P = 0.001), the glomerular filtration rate (hazard ratio: 0.98; 95 % CI: 0.96-0.99; P = 0.03), and male gender (hazard ratio: 4.76; 95 % CI: 1.08-20.90; P = 0.04) were independent predictors of major adverse cardiovascular events. Thoracic periaortic fat tissue volume may be considered a useful new parameter for predicting major adverse cardiovascular events.Öğe The Relationship among Thiazide Like Diuretic, Uric Acid and Erectile Dysfunction in Hypertensive Subjects(Elsevier Science Inc, 2013) Aribas, Alpay; Kayrak, Mehmet; Ulucan, Seref; Keser, Ahmet; Demir, Kenan; Alibasic, Hayrudin; Akilli, Hakan[Abstract Not Availabe]Öğe The relationship between uric acid and erectile dysfunction in hypertensive subjects(Taylor & Francis Ltd, 2014) Aribas, Alpay; Kayrak, Mehmet; Ulucan, Seref; Keser, Ahmet; Demir, Kenan; Alibasic, Hayrudin; Akilli, HakanBackground. Endothelial dysfunction plays a major role in erectile dysfunction (ED). Uric acid (UA) is a marker of endothelial dysfunction. We hypothesized that increased UA levels may be associated with ED and aimed to investigate whether there is a relationship between, UA and ED in hypertensive patients. Methods. A total of 200 hypertensive patients who have a normal treadmill exercise test were divided into two groups based on the Sexual Health Inventory for Men (SHIM) test (<21 defi ned as ED n = 110, and >= 21 defi ned as normal erectile function n = 90). The differences between the ED and normal erectile function groups were compared and determinants of ED were analyzed. Main results. The prevalence of ED was found to be 55.0%. Office blood pressure level was comparable between groups. UA levels were significantly increased in the ED group (6.20 +/- 1.56 vs 5.44 +/- 1.32, p = 0.01). In a regression model, age [odds ratio (95% confidence interval): 1.08 (1.04-1.14), p = 0.001], smoking [odds ratio: 2.33 (1.04-5.20), p = 0.04] and UA [odds ratio: 1.76 (1.28-2.41), p = 0.04] were independent determinants of ED. An UA level of >5.2 mg/dl had 76.2% sensitivity, 43.7% specificity, 62.9% positive and 59.4% negative predictive value for determining ED. Conclusion. UA is an independent determinant of ED irrespective of blood pressure control and questioning erectile function for hypertensive patients with increased UA levels may be recommended.
