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    The effects of agomelatine, fluoxetine, and sertraline on rat bladder contraction in vitro
    (Kare Publ, 2023) Gormus, Zulfikare Isik Solak; Vidin, Tuba; Koca, Raviye Ozen; Solak, Hatice; Uslu, Esra Fidan
    Objective: This study aimed to determine the potential effects of three popular antidepressants: agomelatine, fluoxetine, and sertraline on in vitro rat bladder contraction responses, and to investigate their contribution to overactive bladder syndrome. Method: Thirty-two adult male Wistar albino rats, weighing between 300-350 g, were randomly divided into four groups (Control, Agomelatine, Fluoxetine, Sertraline). After cervical dislocation, the bladders were promptly removed, cut into 3-4-millimeter strips, and suspended in an isolated organ bath at a tension of 1 gram. Contractions were induced by acetylcholine (ACh) at a concentration of 10(-5) M. Cumulative doses of agomelatine, fluoxetine, and sertraline (ranging from 10(-8) to 10(-3) M) were administered to the organ bath chambers. The least squares means were compared using the Tukey-Kramer post-hoc test to compare the tension values of the groups at different time points.Results: The inhibition of rat bladder contractions was statistically significant at agomelatine doses of 10(-7) M (p=0.0413), 10(-6) M (p=0.033), 10(-5)M (p=0.003), and 10(-4) M (p<0.001), with a statistically significant recontraction response noticed after the agomelatine dose of 10(-3) M (p<0.001). Cumulative fluoxetine doses at 10(-7) M (p=0.0182), 10(-6) M (p=0.0012), and 10(-5), 10(-4), 10(-3) M (all at p<0.001), along with sertraline doses at 10(-5) M (p=0.0096), 10(-4) M (p=0.001), and 10(-3) M (p<0.001), also significantly inhibited contraction. Conclusion: Agomelatine, fluoxetine, and sertraline were found to exhibit inhibitory effects on bladder contraction in a dose-dependent manner.
  • Küçük Resim Yok
    Öğe
    The effects of agomelatine, fluoxetine, and sertraline on rat bladder contraction in vitro
    (Kare Publ, 2023) Gormus, Zulfikare Isik Solak; Vidin, Tuba; Koca, Raviye Ozen; Solak, Hatice; Uslu, Esra Fidan
    Objective: This study aimed to determine the potential effects of three popular antidepressants: agomelatine, fluoxetine, and sertraline on in vitro rat bladder contraction responses, and to investigate their contribution to overactive bladder syndrome. Method: Thirty-two adult male Wistar albino rats, weighing between 300-350 g, were randomly divided into four groups (Control, Agomelatine, Fluoxetine, Sertraline). After cervical dislocation, the bladders were promptly removed, cut into 3-4-millimeter strips, and suspended in an isolated organ bath at a tension of 1 gram. Contractions were induced by acetylcholine (ACh) at a concentration of 10(-5) M. Cumulative doses of agomelatine, fluoxetine, and sertraline (ranging from 10(-8) to 10(-3) M) were administered to the organ bath chambers. The least squares means were compared using the Tukey-Kramer post-hoc test to compare the tension values of the groups at different time points.Results: The inhibition of rat bladder contractions was statistically significant at agomelatine doses of 10(-7) M (p=0.0413), 10(-6) M (p=0.033), 10(-5)M (p=0.003), and 10(-4) M (p<0.001), with a statistically significant recontraction response noticed after the agomelatine dose of 10(-3) M (p<0.001). Cumulative fluoxetine doses at 10(-7) M (p=0.0182), 10(-6) M (p=0.0012), and 10(-5), 10(-4), 10(-3) M (all at p<0.001), along with sertraline doses at 10(-5) M (p=0.0096), 10(-4) M (p=0.001), and 10(-3) M (p<0.001), also significantly inhibited contraction. Conclusion: Agomelatine, fluoxetine, and sertraline were found to exhibit inhibitory effects on bladder contraction in a dose-dependent manner.