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    Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents
    (Walter De Gruyter Gmbh, 2016) Can, Ummugulsum; Buyukinan, Muammer; Guzelant, Asuman; Ugur, Ayse; Karaibrahimoglu, Adnan; Yabanciun, Sukriye
    Background: Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), alpha(2)-macroglobulin (alpha(2)-MG), platelet factor-4 (PF-4), fetuin-A, serum amyloid P (SAP) and alpha(1)-acid glycoprotein (AGP) in an adolescent population with MetS. Methods: This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70 +/- 1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, alpha(2)-MG, PF-4, fetuin-A, SAP and AGP were measured by using a multi-ELISA technique. Results: Serum Hp, fetuin-A (p < 0.01) and PF-4, hs-CRP, SAP, AGP (p < 0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum alpha(2)-MG levels between the MetS and control groups (p = 0.184). Conclusions: This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.
  • Küçük Resim Yok
    Öğe
    Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents
    (Walter De Gruyter Gmbh, 2016) Can, Ummugulsum; Buyukinan, Muammer; Guzelant, Asuman; Ugur, Ayse; Karaibrahimoglu, Adnan; Yabanciun, Sukriye
    Background: Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), alpha(2)-macroglobulin (alpha(2)-MG), platelet factor-4 (PF-4), fetuin-A, serum amyloid P (SAP) and alpha(1)-acid glycoprotein (AGP) in an adolescent population with MetS. Methods: This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70 +/- 1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, alpha(2)-MG, PF-4, fetuin-A, SAP and AGP were measured by using a multi-ELISA technique. Results: Serum Hp, fetuin-A (p < 0.01) and PF-4, hs-CRP, SAP, AGP (p < 0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum alpha(2)-MG levels between the MetS and control groups (p = 0.184). Conclusions: This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.