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    Assessment of cardiovascular functions in children with attention-deficit/hyperactivity disorder who are new users of methylphenidate
    (Kuwait Medical Assoc, 2020) Sargin, Fatma; Oflaz, Mehmet Burhan; Yar, Ahmet; Baysal, Tamer
    Objectives: It was aimed to evaluate cardiovascular functions via blood pressure and electrocardiogram (ECG) of patients with attention deficit and hyperactivity disorder (ADHD) who were treated with methylphenidate. Design: This is a descriptive and prospective study. Settings: Necmettin Erbakan University Meram Faculty of Medicine and Konya Training and Research Hospital, Turkey Subjects: Thirty-five patients with ADHD who were selected to be treated with methylphenidate were evaluated using ECG, heart rate (beats/minute), systolic blood pressure (mmHg) and diastolic blood pressure (mmHg) recorded before treatment, and after 1st month and 3rd month of treatment. Interventions: Heart rate, rhythm, QRS axis, P-R interval, P dispersion, QT dispersion, QTc interval and QTc dispersion were measured on ECG. Main outcome measures: ECG changes of patients with ADHD who were treated with methylphenidate Results: There were no statistically significant differences in the heart rate, systolic blood pressure, diastolic blood pressure, P-R interval, P dispersion, QT dispersion and QTc dispersion between the measurements performed at baseline and at one and three months of treatment. Statistically significantly increased QRS axes were observed at baseline, and at one and three months of treatment, although this increase was not clinically significant. None of the patients had adverse cardiovascular events. Conclusion: In conclusion, methylphenidate which is used commonly in the treatment of ADHD does not alter the heart rate, blood pressure and ECG recordings at one and three months of treatment compared to the baseline.
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    Functional Vomiting Treated Successfully with Aripiprazole in a Child with Autism Spectrum Disorder
    (Mary Ann Liebert, Inc, 2016) Acikel, Burak; Yar, Ahmet; Herguner, Sabri
    [Abstract Not Availabe]
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    Retinal Nerve Fiber Layer Thickness in Children With ADHD
    (Sage Publications Inc, 2018) Herguner, Arzu; Alpfidan, Ismail; Yar, Ahmet; Erdogan, Erkan; Metin, Ozge; Sakarya, Yasar; Herguner, Sabri
    Objectives: The current study aims to compare retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume between children with ADHD and a control group. Method: The study group included children with ADHD and the control group consisted of age- and gender-matched participants without any psychiatric disorder. In all participants, RNFL thickness, macular thickness, and macular volume were measured by using spectral domain-optical coherence tomography (SD-OCT). ADHD symptom severity was evaluated by using parent-report measures, including Conners' Parent Rating Scale-Revised: Short Form (CPRS-R: S) and the Strengths and Difficulties Questionnaire: Parent Form (SDQ: P). Results: We compared 90 eyes of 45 children with ADHD and 90 eyes of 45 controls. ADHD group had significantly lower RNFL thickness only in nasal quadrant than the controls. The remaining RNFL quadrants, macular thickness, and volume were not significantly different between groups. There was a reverse correlation between RNFL thickness and ADHD symptom severity. Conclusion: This is the first study examining the RNFL thickness in ADHD. Our findings showed that nasal RNFL thickness was lower, indicating reduced unmyelinated axons in the retina of children with ADHD. The results of this study support the evidence that ADHD involves a lag in cortical maturation and this is measurable in the retina.