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Öğe Assessment of Self-Reported Periodontal Aesthetic, Quality of Life and Dental Anxiety after Free Gingival Graft Procedures(Amber Publication, 2022) Yarkac, Fatma Ucan; Gokturk, Ozge; Sengul, Betul Iriz; Babayigit, OsmanIntroduction: Gingival recessions, which are very common mucogingival deformities, affect the function as well as the esthetic appearance of the patients, especially when localized or common in the anterior teeth. Aims: The aim of this study was to investigate self-reported periodontal aesthetics, quality of life and anxiety after the free gingival graft. Materials and Methods: Thirty-nine subjects with gingival recession were treated surgically and followed up for 6 months. Vertical recession and keratinized tissue width were assessed before and after treatment. Patients were asked to answer the Oral Health Impact Profile (OHIP) -14, the Dental Anxiety Scale (DAS), and the Periodontal Aesthetic Perception Scale (PAPS) at the baseline, at 1 and 6 months. Results: Average keratinized tissue width significantly increased from baseline to land 6 months (p<0.05). At the same time, vertical recession significantly decreased from baseline to 1 and 6 months (p<0.0.5). in addition, PAPS scores and Psychological effect and aesthetic effect subscales, OHIP-14 and DAS scores showed a statistically significant difference between at baseline to 6 months (p<0.05). Conclusion: Free gingival graft operation can improve patients' self-reported periodontal aesthetic and quality of life, as well as reduce patients' dental anxiety.Öğe The Association Between Sleep Quality, Fatigue and Periodontal Status: a Pilot Study(Univ Costa Rica, Fac Odontologia, 2023) Eroglu, Zeynep Tastan; Ozkan, Dilek; Yarkac, Fatma Ucan; Altiparmak, FatmaReduced sleep duration, poor sleep quality and fatigue are related to reduced immunity and increased inflammatory markers. Due to its potential to influence inflammation, poor sleep quality and fatigue could be factors for periodontitis and quality of life. Ninety-three individuals with untreated periodontitis and thirty-one individuals with healthy gingiva were included in the study. The research involved a clinical examination and a questionnaire. Demographic information, information on oral health, oral hygiene habits, the Pittsburgh Sleep Quality Index, Jenkins Sleep Scale, Multidimensional Assessment of Fatigue Scale, and Oral Health Impact Profile-14 were included in the questionnaire. Patients were diagnosed based on the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. No statistically significant difference was revealed between sleep quality, fatigue, oral health related quality of life, and stage-grade of periodontitis (p<0.05). However, periodontitis group had higher Oral Health Impact Profile-14 scores (p<0.05). A statistically significantly lower sleep duration was observed in stage IV periodontitis group than the other groups (p<0.05). A statistically significant positive correlation was observed between the Pittsburgh Sleep Quality Index and the scores of the other questionnaires (p<0.05). The stage of periodontitis may impact sleep duration.Öğe The Association Between Sleep Quality, Fatigue and Periodontal Status: a Pilot Study(Univ Costa Rica, Fac Odontologia, 2023) Eroglu, Zeynep Tastan; Ozkan, Dilek; Yarkac, Fatma Ucan; Altiparmak, FatmaReduced sleep duration, poor sleep quality and fatigue are related to reduced immunity and increased inflammatory markers. Due to its potential to influence inflammation, poor sleep quality and fatigue could be factors for periodontitis and quality of life. Ninety-three individuals with untreated periodontitis and thirty-one individuals with healthy gingiva were included in the study. The research involved a clinical examination and a questionnaire. Demographic information, information on oral health, oral hygiene habits, the Pittsburgh Sleep Quality Index, Jenkins Sleep Scale, Multidimensional Assessment of Fatigue Scale, and Oral Health Impact Profile-14 were included in the questionnaire. Patients were diagnosed based on the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. No statistically significant difference was revealed between sleep quality, fatigue, oral health related quality of life, and stage-grade of periodontitis (p<0.05). However, periodontitis group had higher Oral Health Impact Profile-14 scores (p<0.05). A statistically significantly lower sleep duration was observed in stage IV periodontitis group than the other groups (p<0.05). A statistically significant positive correlation was observed between the Pittsburgh Sleep Quality Index and the scores of the other questionnaires (p<0.05). The stage of periodontitis may impact sleep duration.Öğe Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model(De Gruyter Poland Sp Z O O, 2023) Kocabas, Rahim; Yarkac, Fatma Ucan; Karabulut, Ercan; Keles, MertPeriodontitis is a chronic inflammatory disease that destroys the bones and soft tissues that support the tooth as a result of inflammatory reactions. YKL-40 is an inflammatory marker associated with inflammation and is also associated with periodontal diseases. Moringa oleifera (MO) is a plant rich in high nutritional values, minerals, vitamins, and other essential phytochemicals. The aim of this study was to investigate the effect of MO administration on serum YKL-40 levels in an experimental periodontitis model. In the study, a total number of 24 female Wistar albino rats, which were 4-5 months old with a body weight of 275 +/- 25 g, were used. Animals were divided into three groups. 1st group: Control (n = 8), 2nd group: periodontitis group (PG) (n = 8), 3rd group: Periodontitis group (PG + MO) with an additional 200 mg/kg/4 weeks MO (n = 8). In the PG and PG + MO were formed experimental periodontitis model. Compared to the PG, the decrease in the interleukin-6 (IL-6) and YKL-40 values in the PG + MO (p < 0.05, p < 0.05) was found to be significant in terms of statistical evaluation. As a result, MO decreased YKL-40 levels in the experimental periodontitis model. Although further research is needed, drugs containing MO can be used in the treatment of periodontal diseases.Öğe Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model(De Gruyter Poland Sp Z O O, 2023) Kocabas, Rahim; Yarkac, Fatma Ucan; Karabulut, Ercan; Keles, MertPeriodontitis is a chronic inflammatory disease that destroys the bones and soft tissues that support the tooth as a result of inflammatory reactions. YKL-40 is an inflammatory marker associated with inflammation and is also associated with periodontal diseases. Moringa oleifera (MO) is a plant rich in high nutritional values, minerals, vitamins, and other essential phytochemicals. The aim of this study was to investigate the effect of MO administration on serum YKL-40 levels in an experimental periodontitis model. In the study, a total number of 24 female Wistar albino rats, which were 4-5 months old with a body weight of 275 +/- 25 g, were used. Animals were divided into three groups. 1st group: Control (n = 8), 2nd group: periodontitis group (PG) (n = 8), 3rd group: Periodontitis group (PG + MO) with an additional 200 mg/kg/4 weeks MO (n = 8). In the PG and PG + MO were formed experimental periodontitis model. Compared to the PG, the decrease in the interleukin-6 (IL-6) and YKL-40 values in the PG + MO (p < 0.05, p < 0.05) was found to be significant in terms of statistical evaluation. As a result, MO decreased YKL-40 levels in the experimental periodontitis model. Although further research is needed, drugs containing MO can be used in the treatment of periodontal diseases.Öğe The effect of vanillic acid on ligature-induced periodontal disease in Wistar rats(Pergamon-Elsevier Science Ltd, 2019) Karatas, Ozkan; Yuce, Hatice Balci; Taskan, Mehmet Murat; Gevrek, Fikret; Yarkac, Fatma Ucan; Keskin, Ash; Karatas, Sukruye Firuze OcakObjective: Vanillic acid, also known as 4-hydroxy-3-methoxy benzoic acid has a potent effect on bone metabolism. The purpose of the present study was to specify the effects of vanillic acid (VA) on preventing inflammation and bone destruction in experimental periodontitis as inflammatory bone disease. To evaluate the effects of VA, osteoblast, osteoclast and inflammatory cell counts, iNOS, CD68, MMP-1, and TIMP-1 levels were determined. Methods: 32 female Wistar rats were divided into four experimental groups as; Group 1: healthy control (C, n = 8), group 2: Periodontitis (P, n = 8), group 3: periodontitis and 50 mg/kg VA administered group (P + VA 50, n = 8) and group 4: periodontitis and 100 mg/kg VA delivered group (P + VA-100, n = 8). Ligature-induced experimental periodontitis was carried out at mandibular first molar teeth of the right quadrant by placing submarginal 4-0 silk ligatures. VA was administered by oral gavage for 14 days beginning from the first day. Rats were euthanized on the 15th day. Morphological changes in alveolar bone were evaluated via a stereomicroscope. Mandibles were subjected to histological procedures. Osteoblasts, tartrate-resistant acid phosphatase synthesizing osteoclasts and inflammatory cells were counted. Inducible nitric oxide synthase (iNOS), cluster of differentiation (CD)-68, Matrix metalloproteinase (MMP)-1, tissue inhibitor of MMP-1, runt-related x factor-2 (RUNX2), and cyclooxygenase (COX)-2 expressions were determined by immunohistochemistry. Results: The rats in the periodontitis group had the highest alveolar bone loss compared to the other groups. Both doses of VA significantly decreased alveolar bone loss but not the control levels. TRAP-positive osteoclast and inflammatory cell counts were also highest in the P group, and both 50 and 100 mg/kg VA reduced these counts. Control rats had the lowest osteoclast and inflammatory cell counts compared to the other groups. Similar to osteoclast counts, MMP-1, iNOS, CD68, and COX-2 expressions were the highest in the P group compared to the other groups. Both doses of VA significantly decreased these levels. Osteoblast cells were higher in the VA groups compared to the control and periodontitis groups. RUNX2 levels were lower in the periodontitis group compared to the control group. A slight increase was also observed in VA groups. However, the difference in the TIMP-1 levels was significant only between P and VA100 groups. Conclusion: VA administration successfully ameliorated periodontitis symptoms by decreasing alveolar bone and collagen destruction, periodontal inflammation, and increasing osteoblastic activity.Öğe Effects of non-surgical periodontal therapy on inflammatory markers of psoriasis: A randomized controlled trial(Wiley, 2020) Yarkac, Fatma Ucan; Ogrum, Atiye; Gokturk, OzgeAim The purpose of this randomized controlled clinical study was to evaluate the effect of non-surgical mechanical periodontal therapy on the inflammatory status and severity of psoriasis in subjects with psoriasis. Material and methods The study population consisted of 92 periodontitis patients with psoriasis vulgaris suffering from an untreated periodontal disease. Two randomized groups were formed from these patients: immediate periodontal therapy (test group, n = 46) and delayed periodontal therapy (control group, n = 46). Periodontal clinical measures, on salivary interleukin 2, interleukin 6 and secretory immunoglobulin A levels and the Psoriasis Area and Severity Index (PASI) scores were evaluated at baseline and on the 8th week in control and test groups. Results Eight weeks after completion of non-surgical periodontal therapy (test group) or initial examination (control group), a significant decrease was observed in interleukin 2, interleukin 6 level and in PASI score, whereas a significant increase was observed in secretory immunoglobulin A levels in the test group (p < .05). Conclusion Within the limits of this study, the results suggest that effective periodontal therapy improves the psoriasis condition in patients afflicted by both diseases.Öğe EVALUATION OF RELATIONSHIP BETWEEN GINGIVAL PHENOTYPE AND PERIODONTAL STATUS(Jadoun Science Publishing Group, 2022) Babayigit, Osman; Yarkac, Fatma Ucan; Atay, Ummuhan Tekin; Sen, Dilek Ozkan; Oncu, ElifDetermining the gingival phenotype and knowing its relationship with clinical periodontal parameters is critical in terms of guiding the clinician and the treatment results. The present study evaluated the prevalence of gingival phenotype and its relationship with crown shape, papilla height (PH), keratinized tissue width (KTW), and risk factors. A total of 90 individuals, 53 females and 37 males were included in the study. Based on the transparency of a periodontal probe through the buccal gingival margin, was determined thin phenotype and thick phenotype groups. Sociodemographic data, oral hygiene status and clinical periodontal parameters, supracrestal gingival height (SGH), crown width/crown length ratio, PH, and KTW were evaluated. No statistical difference (p>0.05) was detected neither for the correlation between different phenotypes (thick/thin) and SGH nor for associating phenotypes and crown width/crown length ratio. Additionally, there was no statistically significant difference in periodontal parameters and PH between thick and thin phenotype groups (p>0.05). PH was higher for individuals with rectangular crown shapes compared to individuals with square crown shapes (p<0.05). It was found that the prevalence of rectangular and square crown shapes was equal and the thick gingival phenotype was higher in the Turkish population. There was no correlation between the gingival phenotype and crown shape, periodontal parameters, and papilla heights. It has been shown that individuals with a thick phenotype have higher KTW and the shape of the crown in the anterior region of the maxilla affects the height of the papilla. Copyright (C) 2013 - All Rights Reserved - PharmacophoreÖğe Potential Use of ChatGPT for Patient Information in Periodontology: A Descriptive Pilot Study(Springernature, 2023) Babayigit, Osman; Eroglu, Zeynep Tastan; Sen, Dilek Ozkan; Yarkac, Fatma UcanObjectivesThe aim of this study is to evaluate the accuracy and completeness of the answers given by Chat Generative Pre-trained Transformer (ChatGPT) (OpenAI OpCo, LLC, San Francisco, CA), to the most frequently asked questions on different topics in the field of periodontology. MethodsThe 10 most frequently asked questions by patients about seven different topics (periodontal diseases, peri-implant diseases, tooth sensitivity, gingival recessions, halitosis, dental implants, and periodontal surgery) in periodontology were created by ChatGPT. To obtain responses, a set of 70 questions was submitted to ChatGPT, with an allocation of 10 questions per subject. The responses that were documented were assessed using two distinct Likert scales by professionals specializing in the subject of periodontology. The accuracy of the responses was rated on a Likert scale ranging from one to six, while the completeness of the responses was rated on a scale ranging from one to three. ResultsThe median accuracy score for all responses was six, while the completeness score was two. The mean scores for accuracy and completeness were 5.50 +/- 0.23 and 2.34 +/- 0.24, respectively. It was observed that ChatGPT's responses to the most frequently asked questions by patients for information purposes in periodontology were at least nearly completely correct in terms of accuracy and adequate in terms of completeness. There was a statistically significant difference between subjects in terms of accuracy and completeness (P<0.05). The highest and lowest accuracy scores were peri-implant diseases and gingival recession, respectively, while the highest and lowest completeness scores were gingival recession and dental implants, respectively. ConclusionsThe utilization of large language models has become increasingly prevalent, extending its applicability to patients within the healthcare domain. While ChatGPT may not offer absolute precision and comprehensive results without expert supervision, it is apparent that those within the field of periodontology can utilize it as an informational resource, albeit acknowledging the potential for inaccuracies.
