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Öğe THE ASSOCIATION BETWEEN HRQOL, OTHER FACTORS AND MORTALITY IN PD PATIENTS WHO WERE FOLLOWED FOR 7 YEARS(Oxford Univ Press, 2013) Guney, Ibrahim; Turkmen, Kultigin; Yazici, Raziye; Aslan, Sevket; Altintepe, Lutfullah; Yeksan, Mehdi[Abstract Not Availabe]Öğe Does the serum uric acid level have any relation to arterial stiffness or blood pressure in adults with congenital renal agenesis and/or hypoplasia?(Taylor & Francis Inc, 2017) Yazici, Raziye; Guney, Ibrahim; Altintepe, Lutfullah; Yazici, MehmetBackground: The relationship between serum uric acid and arterial stiffness or blood pressure is not clear. The serum uric acid level and its association with cardiovascular risk is not well known in patients with reduced renal mass. We aimed to investigate the relation between serum uric acid levels and arterial stiffness and also blood pressure in patients with congenital renal agenesis and/or hypoplasia. Material and Methods: In this single center, cross-sectional study, a total of 55 patients (39 (% 70.9) with unilateral small kidney and 16 (% 29.1) with renal agenesis) were included. The median age was 35 (21-50) years. The study population was divided into tertiles of serumuric acid (according to 2.40-3.96, 3.97-5.10, and 5.11-9.80mg/dl cut-off values of serum uric acid levels). Official and 24-h ambulatory non-invasive blood pressures of all patients were measured. The arterial stiffness was assessed by pulse wave velocity (PWV). Results: PWV values were increased from first to third tertile (5.5 +/- 0.6, 5.7 +/- 0.8, 6.1 +/- 0.7, respectively), but this gradual increase between tertiles did not reach significance. Linear regression analyses showed a positive correlation between serum uric acid levels and PWV (beta = 0.40, p = 0.010), but no correlation was found between uric acid and daytime systolic blood pressure (beta = 0.24, p = 0.345). Conclusion: In congenital renal agenesis/hypoplasia, the serumuric acid level was positively correlated with arterial stiffness, but there was no correlation with blood pressure.Öğe Health-related quality of life, depression and mortality in peritoneal dialysis patients in Turkey: seven-year experience of a center(Informa Healthcare, 2014) Turkmen, Kultigin; Guney, Ibrahim; Yazici, Raziye; Arslan, Sevket; Altintepe, Lutfullah; Yeksan, MehdiIntroduction: Impairment of health-related quality of life (HRQoL) and being in a depressive mood were found to be associated with increased mortality in peritoneal dialysis (PD) patients. We aimed to investigate the association between HRQoL, depression, other factors and mortality in PD patients. Materials and methods: Totally 171 PD patients were included and followed for 7 years in this prospective study. Results: Of 171 PD patients, 45 (26.3%) deceased, 18 (10.5%) maintained on PD, 87 (50.9%) shifted to hemodialysis (HD) and 21 (12.3%) underwent transplantation. The most common cause of death was cardiovascular disease (32, 71.1%) followed by infection (6, 13.3%), cerebrovascular accident (5, 11.2%). The etiology of patients who shifted to HD was PD failure (41, 47.1%), peritonitis (33, 37.9%), leakage (6, 6.9%), catheter dysfunction (3, 3.4%), self willingness (4, 4.6%). Non-survivors were older than survivors (56.6 +/- 15.0 vs. 43.6 +/- 14.6, p = 0.003). There were also statistically significant difference in terms of albumin, residual urine, presence of diabetes and co-morbidity. When the groups were compared regarding HRQoL scores, non-survivors had lower physical functioning (p<0.001), role-physical (p = 0.0045), general health (p = 0.004), role-emotional (p = 0.011), physical component scale (PCS) (p = 0.004), mental component scale (MCS) (p = 0.029). Age, presence of residual urine, diabetes, albumin, PCS and MCS were entered in regression analysis. Decrease of 1 g/dL of albumin and being diabetic were found to be the independent predictors of mortality. Conclusions: Diabetes and hypoalbuminemia but not HRQOL scores were associated with higher mortality in PD patients after 7 years of following period.Öğe Masked hypertension in renal transplant recipients(Taylor & Francis Ltd, 2014) Kayrak, Mehmet; Gul, Enes Elvin; Kaya, Coskun; Solak, Yalcin; Turkmen, Kultigin; Yazici, Raziye; Guney, IbrahimPurpose: Arterial hypertension is a risk factor affecting graft function in renal transplant recipients (RTRs). In pediatric RTRs, high prevalence of masked and nocturnal hypertension was reported. Most of the RTRs had a history of hypertension and some of them were normotensive at outpatient visits whereas home blood pressure (BP) levels were higher. Masked hypertension (MHT) is defined as a normal office BP but an elevated ambulatory BP. Previous reports have demonstrated the detrimental role of MHT in clinical outcomes in hypertensive patients. However, the true prevalence of MHT in RTRs is yet to be defined. Methods: A total of 113 RTRs (mean age 44 +/- 16 years, 72 males, 41 females) with normal office BP (< 140/90 mmHg) were enrolled to the study from the outpatient renal transplantation clinic. Ambulatory BP monitoring (ABPM) was performed in all participants for a 24-h period. Average daytime BP values above 135 mmHg systolic and 85 mmHg diastolic were defined as MHT. Results: The prevalence of MHT in our cohort was 39% (n = 45). Fasting glucose and C-reactive protein levels were higher in patients with MHT compared with normal BP group (p = 0.02 and p = 0.04, respectively). RTRs with deceased donor type had higher prevalence of MHT than RTRs with living donor (40% vs 19%, p = 0.003). In multivariate analysis, deceased donor type could predict the MHT independent of age, gender, office systolic BP level, diabetes mellitus, serum creatinine, C-reactive protein, and glucose levels (OR = 3.62, 95% CI 1.16-11.31, p = 0.03). Conclusion: We demonstrated an increased prevalence of MHT in a typical renal transplant cohort. In addition, transplantation from a deceased donor may be a predictor of MHT. The prevalence of MHT may help to explain high rate of cardiovascular events in RTRs. Therefore, routine application of ABPM in RTRs may be plausible, particularly in RTRs with deceased donor type.Öğe Non-Caseating Granulamatus Nephritis: Rare Sign of Sarcoidosis(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2016) Gencer, Vedat; Guney, Ibrahim; Yazici, Raziye; Esen, Hasan; Aslan, Uysaler; Bolukbas, OzdenSarcoidosis is chronic multisystem granulomatous disease. It can rarely cause renal structural and functional damage. Renal impairment is mostly due to the calcium metabolism and associated with hypercalciuria, nephrolithiasis and nephrocalcinosis. Non-caseating granulomatous nephritis can also be seen in few patients. We diagnosed non-caseating granulomatous nephritis with renal biopsy in a 50-year-old female pulmonary sarcoidosis case. Steroid treatment was immediately started and there was a significant decrease in proteinuria and creatinine after a month. Proteinuria and serum creatinine increase are important in patients with sarcoidosis and treatment must be started immediately to prevent end-stage renal failure.Öğe TECHNICAL SURVIVAL IN PERITONEAL DIALYSIS PATIENTS: QUALITY OF LIFE AND OTHER RELATED FACTORS(Oxford Univ Press, 2013) Guney, Ibrahim; Turkmen, Kultigin; Yazici, Raziye; Arslan, Sevket; Altintepe, Lutfullah; Yeksan, Mehdi[Abstract Not Availabe]
