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Öğe 2003-2011 Yılları arasında meram tıp fakültesi organ nakli merkezinde yapılan böbrek nakli olgularının sonuçları(2013) Türkmen, Kültigin; Erdur, Fatih Mehmet; Gaipov, Abduzhappar; Yeksan, Mehdi; Selçuk, Nedim Yılmaz; Türk, Süleyman; Erikoğlu, Mehmet; Çolak, Bayram; Tekin, Ahmet; Tonbul, Halil Zeki; Tavlı, ŞakirAMAÇ: Son dönem böbrek yetmezliği (SDBY) hastalarında en iyi tedavi şekli böbrek naklidir. Çalışmamızda, son 8 yılda merkezimizde kadavra ve canlıdan yapılan böbrek nakillerinin(BN) demografik verileri ile birlikte böbrek fonksiyonları ve posttransplant medikal komplikasyonları, hasta- graft sağkalımını araştırmayı hedefledik. GEREÇ ve YÖNTEMLER: Çalışmaya 40ı kadavradan, 26sı canlıdan BN yapılan 66 hasta (kadın/ erkek: 36/30) dahil edildi. Nakil sonrası nefroloji polikliniğine başvurularda yaş, cinsiyet, böbrek yetmezliği nedeni, diyaliz türü-süresi, nakil türü, aldıkları indüksiyon tedavileri, kullandığı idame immünsupresif tedaviler, akut rejeksiyon sayısı ve verilen tedaviler, nakil sonrası 1., 6., 12., 24. ve 60. aylardaki biyokimya-hemogram parametreleri ve medikal komplikasyonlar hasta dosyalarından retrospektif olarak elde edildi. BULGULAR: Alıcıların ortalama yaşı 4111,6 yıldı. Ortalama nakil sonrası süre 32,231,4 ay, kreatinin değerleri 1,40,9 mg/dl tespit edildi. En sık uygulanan immünsüpresif tedavi protokolü ko rtikosteroidtakrolimusmikofenolat mofetil/sodyumdu. Gecikmiş graft fonksiyonu, kronik allograft disfonksiyonu ve akut rejeksiyon oranları sırasıyla %27,3, %25,7 ve %13,6 idi. 1 ve 5 yıllık hasta sağkalımı canlıdan yapılan BNlerinde sırasıyla %100 ve %100, kadavradan yapılan BNlerinde ise %85 ve %85 olarak bulundu. 1 ve 5 yıllık graft sağkalımı canlıdan BN yapılanlarda sırasıyla %100 ve %100, kadavradan BN yapılanlarda ise %80 ve %80 olarak saptandı. En sık görülen medikal komplikasyonlar yeni gelişen diyabet ve dislipidemiydi. Erken ve geç dönemde en sık karşılaşılan enfeksiyon idrar yolu enfeksiyonuydu. SONUÇ: BN, hasta-graft sağkalımının yüksek olduğu bir renal replasman tedavi seçeneğidir. Bununla birlikte metabolik komplikasyonlar açısından yakın takip gereklidir.Öğe THE ASSOCIATION BETWEEN HRQOL, OTHER FACTORS AND MORTALITY IN PD PATIENTS WHO WERE FOLLOWED FOR 7 YEARS(Oxford Univ Press, 2013) Guney, Ibrahim; Turkmen, Kultigin; Yazici, Raziye; Aslan, Sevket; Altintepe, Lutfullah; Yeksan, Mehdi[Abstract Not Availabe]Öğe Health-related quality of life, depression and mortality in peritoneal dialysis patients in Turkey: seven-year experience of a center(Informa Healthcare, 2014) Turkmen, Kultigin; Guney, Ibrahim; Yazici, Raziye; Arslan, Sevket; Altintepe, Lutfullah; Yeksan, MehdiIntroduction: Impairment of health-related quality of life (HRQoL) and being in a depressive mood were found to be associated with increased mortality in peritoneal dialysis (PD) patients. We aimed to investigate the association between HRQoL, depression, other factors and mortality in PD patients. Materials and methods: Totally 171 PD patients were included and followed for 7 years in this prospective study. Results: Of 171 PD patients, 45 (26.3%) deceased, 18 (10.5%) maintained on PD, 87 (50.9%) shifted to hemodialysis (HD) and 21 (12.3%) underwent transplantation. The most common cause of death was cardiovascular disease (32, 71.1%) followed by infection (6, 13.3%), cerebrovascular accident (5, 11.2%). The etiology of patients who shifted to HD was PD failure (41, 47.1%), peritonitis (33, 37.9%), leakage (6, 6.9%), catheter dysfunction (3, 3.4%), self willingness (4, 4.6%). Non-survivors were older than survivors (56.6 +/- 15.0 vs. 43.6 +/- 14.6, p = 0.003). There were also statistically significant difference in terms of albumin, residual urine, presence of diabetes and co-morbidity. When the groups were compared regarding HRQoL scores, non-survivors had lower physical functioning (p<0.001), role-physical (p = 0.0045), general health (p = 0.004), role-emotional (p = 0.011), physical component scale (PCS) (p = 0.004), mental component scale (MCS) (p = 0.029). Age, presence of residual urine, diabetes, albumin, PCS and MCS were entered in regression analysis. Decrease of 1 g/dL of albumin and being diabetic were found to be the independent predictors of mortality. Conclusions: Diabetes and hypoalbuminemia but not HRQOL scores were associated with higher mortality in PD patients after 7 years of following period.Öğe THE RELATIONSHIP BETWEEN NEUTROPHIL-TO-LYMPHOCYTE RATIO AND CORONARY ARTERY CALCIFICATION IN END-STAGE RENAL DISEASE PATIENTS(Oxford Univ Press, 2013) Turkmen, Kultigin; Ozcicek, Fatih; Erdur, Fatih; Turk, Suleyman; Yeksan, Mehdi; Tonbul, Halil[Abstract Not Availabe]Öğe Renal Transplant Results of the Organ Transplant Center of Meram Medical School Between 2003-2011(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2013) Turkmen, Kultigin; Fatih, M. Ehmet Erdu R.; Erikoglu, Mehmet; Gaipov, Abduzhappar; Colak, Bayram; Tekin, Ahmet; Yeksan, MehdiBJECTIVE: Renal transplantation (RTx) is the best therapeutic modality for end-stage renal disease patients. We report 8 years single-centre experience on cadaveric and living donor RTx in terms of demographic features along with graft functions, posttransplant medical complications, patients-graft survivals. MATERIAL and METHODS: We enrolled 66 RTx (female/male: 36/30) patients including 40 cadaveric and 26 living donors. At admission age, gender, causes of renal failure, dialysis typeduration, type of RTx, induction and maintenance immunosuppressive modalities, rejection episodes, biochemistry-hemogram parameters at 1, 6, 12, 24 and 60 months after transplantation and medical complications were obtained from the medical records. RESULTS: Mean recipient age was 41 +/- 11.6 years. Mean transplant duration was 32.2 +/- 31.4 months, and the mean creatinine values was 1.4 +/- 0.9 mg/dl. The most commonly used immunosuppressive protocol was corticosteroid+tacrolimus+mycophenolate mofetil. Delayed graft function, chronic allograft nephropathy and acute rejection were observed in 27.3%, 25.7% and 13.6% of patients, respectively. 1-and 5-year patient survival rates were 100% and 100% for living donor patients and 85% and 85% for cadaveric patients, respectively. 1- and 5-year graft survival rates were 100% and 100% for living donor RTx patients, and 80% and 80% for cadaveric RTx patients, respectively. The most common medical complications were new onset diabetes mellitus and dyslipidemia. The most common early and late infection was urinary tract infection. CONCLUSION: RTx is the best renal replacement therapy in terms of patient-graft survival. However, patients should be closely moniterized for metabolic complications.Öğe TECHNICAL SURVIVAL IN PERITONEAL DIALYSIS PATIENTS: QUALITY OF LIFE AND OTHER RELATED FACTORS(Oxford Univ Press, 2013) Guney, Ibrahim; Turkmen, Kultigin; Yazici, Raziye; Arslan, Sevket; Altintepe, Lutfullah; Yeksan, Mehdi[Abstract Not Availabe]
