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  • Küçük Resim Yok
    Öğe
    Effects of Sperm Parameters to Fertility for Intrauterine Insemination Patients According to WHO 2010 Criteria
    (Modestum Ltd, 2015) Tursun, Tugba Sekmenli; Gorkemli, Huseyin; Yilmaz, Fatma Yazici; Aktan, Tahsin Murat
    To evaluate sperm parameters as morphology of sperms in conjunction with number of motile sperms, according to 2010 World Health Organization (WHO) criteria's and to obtain optimal sperm parameters. We have examined prospectively 50 Intrauterine Insemination (IUI) cases for sperm parameters (morphology, TPMSC) and effects of some variables (woman age, infertility duration, FSH level, primary and secondary infertility) to pregnancy rate. First we divided cases in to 2 groups according to TPMSC (Total Progressive Motile Sperm Count) less than 1 million-greater than 1million- and compared number of progressively motile sperms and fertility rate. There was no statistically significant difference between pregnancy rate and sperm morphology (p>0.05) The pregnancy rate for the patient population with TPMSC >1 million was more than another and this was statistically significant (p<0.05). There was no significant fertility difference among subgroups for Morphology and TPMSC as these 2 parameters are evaluated together (p>0.05). There was no significant difference according to age related pregnancy rate (p>0.05). There was no significant statistical differences among groups and subgroups in infertility duration, FSH level and woman age (p>0.05). Our study shows that pregnancy rate has no correlation with sperm morphology -as sperm parameter-for patients that IUI was applied. For the group with TPMSC >1 million, fertility rate was higher and this was statistically significant. Sperm parameters especially TPMSS that are important in determining the treatment plans of infertile patients but the effectiveness of morphology should be discussed.
  • Küçük Resim Yok
    Öğe
    Effects of Sperm Parameters to Fertility for Intrauterine Insemination Patients According to WHO 2010 Criteria
    (Modestum Ltd, 2015) Tursun, Tugba Sekmenli; Gorkemli, Huseyin; Yilmaz, Fatma Yazici; Aktan, Tahsin Murat
    To evaluate sperm parameters as morphology of sperms in conjunction with number of motile sperms, according to 2010 World Health Organization (WHO) criteria's and to obtain optimal sperm parameters. We have examined prospectively 50 Intrauterine Insemination (IUI) cases for sperm parameters (morphology, TPMSC) and effects of some variables (woman age, infertility duration, FSH level, primary and secondary infertility) to pregnancy rate. First we divided cases in to 2 groups according to TPMSC (Total Progressive Motile Sperm Count) less than 1 million-greater than 1million- and compared number of progressively motile sperms and fertility rate. There was no statistically significant difference between pregnancy rate and sperm morphology (p>0.05) The pregnancy rate for the patient population with TPMSC >1 million was more than another and this was statistically significant (p<0.05). There was no significant fertility difference among subgroups for Morphology and TPMSC as these 2 parameters are evaluated together (p>0.05). There was no significant difference according to age related pregnancy rate (p>0.05). There was no significant statistical differences among groups and subgroups in infertility duration, FSH level and woman age (p>0.05). Our study shows that pregnancy rate has no correlation with sperm morphology -as sperm parameter-for patients that IUI was applied. For the group with TPMSC >1 million, fertility rate was higher and this was statistically significant. Sperm parameters especially TPMSS that are important in determining the treatment plans of infertile patients but the effectiveness of morphology should be discussed.
  • Küçük Resim Yok
    Öğe
    The evaluation of recombinant LH supplementation in patients with suboptimal response to recombinant FSH undergoing IVF treatment with GnRH agonist down-regulation
    (Taylor & Francis Ltd, 2015) Yilmaz, Fatma Yazici; Gorkemli, Huseyin; Colakoglu, Mehmet Cengiz; Aktan, Murat; Gezginc, Kazim
    We aimed to evaluate the clinical efficacy of r-LH supplementation to r-FSH in patients with suboptimal response to ovarian stimulation undergoing assisted reproduction with GnRH-a downregulation and stimulation with r-FSH. One-hundred thirty-seven patients were included in the study; among them 52 showed normal ovarian response to stimulation and composed the control group (Group 1), and 85 showed suboptimal response to stimulation and were divided into two groups. For Group 2 (n = 50), 75 IU/L r-LH was added to the treatment, for Group 3 (n = 35) r-FSH dose was increased by 75 IU/L. IVF results were compared between the groups. Implantation rates were 34.8% in control group, and 36.1% and 15% in LH supplementation group and increased-dose r-FSH group, respectively. Implantation rates were statistically significantly higher in Groups 1 and 2 compared to Group 3 (p < 0.02). Pregnancy rate was noticed in 64.7% of Group 1, 57.8% of Group 2 and at 32.4% of Group 3. Pregnancy rate was significantly higher in Group 2 than Group 3 (p < 0.05). r-LH supplementation is an option for improving IVF outcome in patients with suboptimal ovarian response to ovulation induction with r-FSH during GnRH agonist down-regulation. Particularly, r-LH is recommended as it may have a beneficial action on implantation in selected group.