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    Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues
    (Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2018) Aricigil, Mitat; Dundar, Mehmet Akif; Yucel, Abitter; Arbag, Hamdi; Arslan, Abdullah; Aktan, Meryem; Findik, Sidika
    Introduction: To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications. Objective: In this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day. Methods: Thirty-two Wistar Albino rats were divided into four groups. The control group was given no treatment, the hyperbaric oxygen group was given only hyperbaric oxygen therapy, the radiotherapy group was given only radiotherapy, and the radiotherapy plus hyperbaric oxygen group was given both treatments on the same day. Results: Histopathological and biochemical evaluations of specimens were performed. Serum tumor necrosis factor-alpha, interleukin-1 beta, and tissue inflammation levels were significantly higher in the radiotherapy group than in the radiotherapy plus hyperbaric oxygen group, whereas interteukin-10 was higher in the radiotherapy plus hyperbaric oxygen group. Conclusion: When radiotherapy and hyperbaric oxygen are administered on the same day, inflammatory cytokines and tissue inflammation can be reduced in an early period of radiation injury. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.
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    Bilateral Sudden Sensorineural Hearing Loss after Treatment of Aneurysmal Subarachnoid Hemorrhage by Angiographic Embolization: A Case Report
    (Galenos Yayincilik, 2014) Ulku, Cagatay Han; Yucel, Abitter
    Bilateral sudden sensorineural hearing loss is a rare otologic emergency and constitutes 0.44%-4.9% of overall sudden sensorineural hearing loss cases. Microvascular dysfunction secondary to systemic cardiovascular diseases, such as embolism, vasospasm, and hypercoagulability, is the main cause of non-idiopathic bilateral sudden sensorineural hearing loss. In this study, a case of bilateral sudden sensorineural hearing that occurred after angiographic embolization for treatment of aneurysmal subarachnoid hemorrhage was presented as a rare clinical condition.
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    Determination of hearing levels in gout patients and factors affecting hearing levels such as the dislipidemia, hemoglobin levels and hyperuricemia
    (W B Saunders Co-Elsevier Inc, 2020) Yucel, Abitter; Yucel, Hilal; Aydemir, Fuat; Cure, Erkan; Eryilmaz, Mehmet Akif; Cizmecioglu, Hilal Akay; Kucuk, Adem
    [Abstract Not Availabe]
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    The evaluation of cochlear functions in Familial Mediterranean Fever
    (Springer, 2016) Eryilmaz, Mehmet Akif; Yucel, Abitter; Cure, Erkan; Sakiz, Davut; Koder, Ahmet; Kucuk, Adem; Tunc, Recep
    Familial Mediterranean Fever (FMF) is a progressive disease characterized by chronic inflammation, which also has negative effects on cochlear functions and hearing levels. We investigated whether the cochlear functions and hearing levels of FMF patients were different than healthy controls and also evaluated the relationship of hearing levels with the age at diagnosis, duration without treatment, and inflammation and lipid parameters in this study. A total of 60 patients diagnosed with FMF and 48 age, gender and body mass index (BMI)-matched healthy controls were included in the study. The hemogram, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and lipid parameters of the subjects were studied and they all underwent pure tone audiometry and Transient evoked otoacoustic emission tests after an otologic examination. The hearing levels of the FMF group were significantly higher than those of the control group. The TEOAE signal/noise (S/N) ratios were similar in both groups. A positive relationship was present between the audiometric test results and the age, BMI, low-density lipoprotein and triglyceride levels and a negative relationship with the high-density lipoprotein levels. A negative relationship was present between the TEOAE S/N ratios and the age of the patients, duration without treatment, lipid parameters, inflammation markers and the creatinine level. FMF patients are exposed to chronic inflammation and this can influence their hearing levels. The age at diagnosis, duration without treatment, chronic inflammation, unfavorable lipid parameters, and obesity can affect hearing tests negatively.
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    Melatonin prevents possible radiotherapy-induced thyroid injury
    (Taylor & Francis Ltd, 2017) Aricigil, Mitat; Dundar, Mehmet Akif; Yucel, Abitter; Eryilmaz, Mehmet Akif; Aktan, Meryem; Alan, Mehmet Akif; Findik, Sidika
    Purpose: We aimed to investigate the protective effect of melatonin in radiotherapy-induced thyroid gland injury in an experimental rat model.Materials and methods: Thirty-two rats were divided into four groups: the control group, melatonin treatment group, radiotherapy group and melatonin plus radiotherapy group. The neck region of each rat was defined by simulation and radiated with 2 Gray (Gy) per min with 6-MV photon beams, for a total dose of 18Gy. Melatonin was administered at a dose of 50mg/kg through intraperitoneal injection, 15min prior to radiation exposure. Thirty days after the beginning of the study, rats were decapitated and analyses of blood and thyroid tissue were performed.Results: Tumor necrosis factor- (TNF-), interleukin-1 beta (IL-1), thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels in the radiotherapy group were significantly higher than those in the melatonin plus radiotherapy group (p<.05), whereas interleukin-10 (IL-10) and glutathione (GSH) values were higher in the melatonin plus radiotherapy group (p<.05). The infiltration of inflammatory cells and percentage of apoptosis in the radiotherapy group were significantly higher than those in the melatonin plus radiotherapy group (p<.05).Conclusions: Melatonin helped protect thyroid gland structure against the undesired cytotoxic effects of radiotherapy in rats.
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    Possible Effects of Chronic Otitis Media with and without Cholesteatoma on Bone Conduction Thresholds: An Evaluation of 112 Cases
    (Dergipark Akad, 2019) Ulku, Cagatay Han; Aydogdu, Demet; Yucel, Abitter; Aydemir, Fuat
    Objective: The aim of this study is to evaluate any possible effects of chronic otitis media (COM), with or without accompanying cholesteatoma, on bone conduction thresholds (BCT). Methods: A total of 112 cases who underwent surgery for unilateral COM between 2006 and 2014 were enrolled in the study. Eighty cases had no cholesteatoma (Group 1). Thirty-two cases did have cholesteatoma (Group 2). Prior to surgery, the temporal bone was evaluated radiologically by use of high resolution computed tomography. The presence of a clinically and radiologically normal contralateral ear was the principal selection criterion for the cases. BCT at 0.5, 1, 2, 4 kHz and their averages were evaluated with pure tone audiogram (PTA) and the normal and diseased ears in each group were compared. This comparison was also made between the diseased ears in Groups 1 and 2. Results: There was a statistically significant difference observed between the mean BCT scores obtained by PTA for the normal/diseased ears in Group 1(9.78 +/- 0.98/17.34 +/- 1.71 dB) and in Group 2 (9.10 +/- 0.99/17.58 +/- 2.59 dB). This statistically significant difference was observed for each of the four different frequencies (p<0.0001). However, there was no statistically significant difference observed between the mean BCT scores obtained by PTA for the diseased ears in Groups 1 and 2 (17.34 +/- 1.71/17.58 +/- 2.59 dB). Similarly, in the comparison between the diseased ears, the differences of BCT at all four different frequencies (0.5, 1, 2, 4 kHz) lacked statistical significance (p>0.05). Conclusion: As a result of this study, we can say that COM may lead to sensorineural hearing loss. However, we observed that the presence of cholesteatoma does not exert an additional negative effect on cochlear function.