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Öğe Does atopy affect the course of viral pneumonia?(Elsevier Espana Slu, 2018) Erdem, S. B.; Can, D.; Girit, S.; Catal, F.; Sen, V.; Pekcan, S.; Yuksel, H.Background: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia. Methods: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Patients were classified into two groups as mild-moderate and severe according to the course of pneumonia. Presence of atopy was evaluated with skin prick tests. Groups were compared to evaluate the risk factors associated with severe viral pneumonia. Results: A total of 280 patients from nine centres were included in the study. Of these patients, 163 (58.2%) were male. Respiratory syncytial virus (29.7%), Influenza A (20.5%), rhinovirus (18.9%), adenovirus (10%), human metapneumovirus (8%), parainfluenza (5.2%), coronavirus (6%), and bocavirus (1.6%) were isolated from respiratory samples. Eighty-five (30.4%) children had severe pneumonia. Atopic sensitisation was found in 21.4% of the patients. Ever wheezing (RR: 1.6, 95% CI: 1.1-2.4), parental asthma (RR: 1.5, 95% CI: 1.1-2.2), other allergic diseases in the family (RR: 1.8, 95% CI: 1.2-2.9) and environmental tobacco smoke (RR: 1.6, 95% CI: 1.1-3.5) were more common in the severe pneumonia group. Conclusions: When patients with mild-moderate pneumonia were compared to patients with severe pneumonia, frequency of atopy was not different between the two groups. However, parental asthma, ever wheezing and environmental tobacco smoke exposure are risk factors for severe viral pneumonia in children. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Radiation Damage Centers in Cholesteryl Heptanoate(Polish Acad Sciences Inst Physics, 2013) Sayin, U.; Can, C.; Turkkan, E.; Dereli, O.; Ozmen, A.; Yuksel, H.Cholesterol takes part significantly in many biological mechanisms and as important component for manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. To determine magnetic properties of cholesteryl heptanoate (C34H58O2) which is an important cholesteryl ester in human life and new technology, the single crystals of cholesteryl heptanoate were grown by slow evaporation of concentrated ethyl acetate solution and the grown single crystals were irradiated at room temperature with Co-60 gamma ray. The radical produced by gamma irradiation has been investigated in the range of temperatures 123-330 K for different orientations of the crystal in a magnetic field by EPR. Radiation damage center was attributed to radical (C) over dotH(alpha)CH(2 beta). The g factor and hyperfine coupling constants have slight dependence on temperature and evident dependence on the orientation of the magnetic field. Determined g factor and hyperfine coupling constants for the radical (C) over dotH(alpha)CH(2 beta) were found to be anisotropic with the average values g(av) = 2.0036, (a(CH alpha))(av) = 14.52 G, (a(CH2 beta))(av) = 25.78 G.