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Öğe The effect of epidermal growth factor applied locally for pelviureteral anastomoses(E-Century Publishing Corp, 2014) Yurtcu, Muslim; Baba, Zeliha FusunObjective: To investigate the effect of epidermal growth factor (EGF) on fibrous tissue formation and wound healing in experimental pelviureteral anastomosis (PUA). Materials and Methods: Twelve rabbits were divided equally into 2 groups: control (C) and epidermal growth factor (EGF). A 1-cm length of the ureteropelvic segment was resected through a laparotomy incision and then anastomosis was performed. The rabbits were administered locally with 100 mu g/kg EGF (EGF group) all around the anastomosis lines after the surgical procedure. The C group did not receive any medication during their procedure. Intravenous pyelography was carried out on postoperative day 21. The rabbits were sacrificed and dissected under a dissecting microscope and examined for acute inflammation (AI), chronic inflammation (CI), granulation tissue amount (GTA), granulation tissue fibroblast maturation (GTFM), collagen deposition (CD), neovascularization (N), re-epithelization (R), and peripheral tissue reaction (PTR) in the anastomosis lines 3 weeks later. Results: There were no significant differences in the GTA, N, or R scores in the C group compared with those in the EGF group. In the EGF group, AI and CI scores were lower than they were in the C group. CD, GTFM, and PTR in the EGF group were higher than they were in the C group. Conclusion: EGF did not decrease CD, GTFM, or PTR, but did decrease important parameters in wound healing such as acute inflammation and chronic inflammation in an experimental model of PUA in rabbits.Öğe The effects of orchiectomy and steroid on fertility in experimental testicular atrophy(Korean Soc Reproductive Medicine, 2023) Yurtcu, Muslim; Kozacioglu, Sumeyye; Kocabas, RahimObjective: Despite our understanding of Sertoli cell function and the state of spermatogenesis, the underlying mechanisms remain unclear. This study was conducted to compare the effects of orchiectomy and steroid treatment on fertility in testicular atrophy occurring after testic-ular torsion.Methods: Thirty-three rats were divided into four groups. The atrophy, orchiectomy, and atrophy-steroid groups each contained nine rats, while the control group contained six. The left testes were rotated 720o, and atrophy was observed. In the atrophy-steroid rats, orchiectomy was performed after atrophy, and 1 mg/kg steroid was injected. Each male rat was housed with five female rats for 6 days. The fertility of the male rats was evaluated based on the pregnancy of the female rats. Left and right orchiectomies were performed to determine the tissue Johnsen score (JS) and the serum inhibin B (IB) level.Results: JS values were significantly lower in the atrophy, orchiectomy, and atrophy-steroid groups than in the control group (p<0.05), while no significant difference was observed in JS between the atrophy and orchiectomy groups (p>0.05). Similarly, no significant differences in IB level or fertility percentage were found between the atrophy and orchiectomy rats (p>0.05).Conclusion: In unilateral testicular atrophy, which can occur in the prepubertal period due to various causes, orchiectomy does not appear to benefit fertility, as indicated by IB, JS, and the fertility percentage.Öğe A rare association of anorectal malformation with bladder agenesis, bilateral ectopic ureter, and left pelviureteric junction obstruction(Elsevier Science Inc, 2017) Yurtcu, Muslim; Dilsiz, Alaeddin[Abstract Not Availabe]Öğe A rare presentation: Penile agenesis, vesicoureteral reflux, and rectovesical fistula in a newborn(Elsevier Science Inc, 2019) Yurtcu, MuslimThe penis is an important organ in fertility, urinary and psychosexual structure of males. Complete penile agenesis is a rare congenital genitourinary anomaly and is usually associated with other malformations such as gastrointestinal, cardiac, and musculoskeletal lesions. Although many uncommon types have been reported, penile agenesis associated with vesicoureteral reflux has not been reported in an infant with vesicorectal fistula. This is the first report of an infant with the combination of penile agenesis, vesicoureteral reflux, and vesicorectal fistula. A three-year-old infant with penile agenesis proven to have bilateral vesicoureteral reflux and vesicorectal fistula is reported.