The effects of led-mediated-photobiomodulation therapy on newly formed bone in distraction osteogenesis

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dc.contributor.authorAkcay, Huseyin
dc.contributor.authorEtoz, Osman A.
dc.contributor.authorGuray, Enis
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorAlkan, Alper
dc.date.accessioned2024-02-23T14:38:26Z
dc.date.available2024-02-23T14:38:26Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractAim: The purpose of this experimental study was to determine the effects of light emitting diode-mediated-photobiomodulation therapy (LPT) on newly formed bone in mandibular distraction osteogenesis (DO). Materials and Methods: Sixteen adult male New Zealand white rabbits were involved in the study. Osteotomy was done on left mandibular corpus under general anesthesia. Custom-made external distractors were positioned to left mandibles of animals. The latency period was 5 days, then distractors were activated twice a day for 7 days with 0,5mmx2/day frequency. Sixteen rabbits were randomly divided into experimental (n=8) and control (n=8) groups. Animals in the experimental group were exposed to LPT with an energy density of 20mW/cm2 for 21 consecutive days directly over the distraction area starting with the distraction period. DO was performed without further treatment in the control group. After 30 days of consolidation period, the animals were sacrificed and samples were harvested. Bone mineral density (BMD) and bone mineral content (BMC) of bone formed through DO were evaluated using dual-energy x-ray absorptiometry (DEXA) and bone samples were processed for histological investigation. The data were analyzed using the Student t-test and the Mann-Whitney U test (p=0.05).Results: Bone mineral density was higher in the distraction gap of the experimental group (p=0.013). The number of osteoblasts and new bone forming area were significantly greater in the experimental group than the control group (p<0.05). Discussion: The results showed that LPT had a positive effect on the biomodulation of newly formed bone in DO in a rabbit model. Photobiomodulating effects of LLLT and LPT on bone healing seem similar according to the literature and LPT may be a safe and useful alternative for accelerating the treatment process of DO.en_US
dc.identifier.doi10.4328/ACAM.20063
dc.identifier.endpage267en_US
dc.identifier.issn2667-663X
dc.identifier.issue4en_US
dc.identifier.startpage262en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.20063
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16526
dc.identifier.volume11en_US
dc.identifier.wosWOS:000572683500004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals Of Clinical And Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone Formationen_US
dc.subjectDistraction Osteogenesisen_US
dc.subjectLllten_US
dc.subjectPhotobiomodulation Therapyen_US
dc.titleThe effects of led-mediated-photobiomodulation therapy on newly formed bone in distraction osteogenesisen_US
dc.typeArticleen_US

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