Erdheim-Chester disease diagnosed by 99mTc-MDP bone scintigraphy and brief literature review

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dc.contributor.authorSahin, Ozlem
dc.contributor.authorOltulu, Pembe
dc.date.accessioned2024-02-23T14:49:07Z
dc.date.available2024-02-23T14:49:07Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractErdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis with lipid-laden macrophages and fibrosis. Although ECD is a multisystemic disease, the most common finding is sclerotic bone involvement in the diametaphyseal regions of bilateral distal femur and in proximal and distal tibia. We present a 40 years old woman who for the last two years had various systemic symptoms, especially knee pain, polyuria and polydipsia. Although a hot knee pattern was seen in bone scintigraphy (BS), a femur biopsy was performed, due to the preliminary diagnosis of haematologic malignancy. The biopsy specimen showed only intense fibrosis. One year later while the patient was in our clinic, BS showed characteristic for ECD bone involvement. Bone biopsy specimens stained in hematoxylin and eosin showed dense fibrosis but not histiocytosis. However, after immunohistochemical staining with CD-68, histiocytes were discerned. In conclusion, the authors underline that ECD was diagnosed at a second diagnostic attempt both clinically and by specific staining pathology specimens.en_US
dc.identifier.endpage156en_US
dc.identifier.issn1790-5427
dc.identifier.issue2en_US
dc.identifier.pmid30006650en_US
dc.identifier.scopus2-s2.0-85052197438en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18007
dc.identifier.volume21en_US
dc.identifier.wosWOS:000442206600012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHellenic Soc Nuclear Medicineen_US
dc.relation.ispartofHellenic Journal Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErdheim-Chester Diseaseen_US
dc.subjectBone Scintigraphyen_US
dc.subjectHistiocytosisen_US
dc.subjectBraf Geneen_US
dc.subjectHot Kneeen_US
dc.titleErdheim-Chester disease diagnosed by 99mTc-MDP bone scintigraphy and brief literature reviewen_US
dc.typeReview Articleen_US

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