Donepezil-induced response of Spirulina supplemented rat urinary bladder

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dc.contributor.authorNurullahoglu-Atalik, K. E.
dc.contributor.authorOkudan, N.
dc.contributor.authorGokbel, H.
dc.contributor.authorNurullahoglu, Z. U.
dc.date.accessioned2024-02-23T14:37:57Z
dc.date.available2024-02-23T14:37:57Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractObjective: At present, very little is known about the effects of donepezil on vascular reactivity. The aim of the present study was to evaluate the responses of rat urinary bladder to donepezil (10(-10)-3x10(-4) M) and the role of Spirulina supplementation in these effects. Material and methods: Animals were divided into the two groups of six animals in each group. The first group received only distilled water daily as vehicle for six weeks and served as the control. The second group received Spirulina 750 mg kg (-1) orally, daily for six weeks and served as the spirulina group. Preparations of rat urinary bladder were used from both groups. Results: Donepezil produced concentration dependent relaxation of rat urinary bladder preparations pre-contracted with KCl. The pIC(50) value, but not the maximal response of donepezil, was significantly lower (p<0.05) in the Spirulina supplemented group. Conclusions: These results demonstrated for the first time that spirulina treatment can affect urinary bladder activity (Fig. 1, Ref. 20). Full Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2013_065
dc.identifier.endpage310en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue6en_US
dc.identifier.pmid23731040en_US
dc.identifier.scopus2-s2.0-84878940602en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage308en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2013_065
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16308
dc.identifier.volume114en_US
dc.identifier.wosWOS:000321023200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDonepezilen_US
dc.subjectRaten_US
dc.subjectSpirulinaen_US
dc.subjectUrinary Bladderen_US
dc.titleDonepezil-induced response of Spirulina supplemented rat urinary bladderen_US
dc.typeArticleen_US

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