Prognostic importance of expression of mini-chromosome maintenance proteins (MCMs) in patients with nasopharyngeal cancer treated with curative radiotherapy

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dc.contributor.authorKanyilmaz, Gul
dc.contributor.authorOltulu, Pembe
dc.contributor.authorYavuz, Berrin Benli
dc.contributor.authorAktan, Meryem
dc.date.accessioned2024-02-23T14:02:21Z
dc.date.available2024-02-23T14:02:21Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective: The prognostic importance of minichromosome maintenance complex expression in nasopharyngeal cancer is still unknown. We aimed to find whether minichromosome maintenance complex 2-7 expression may potentially be used to predict the prognosis of nasopharyngeal cancer patients treated with definitive radiotherapy. Methods: Between April 2007 and July 2020, patients with nasopharyngeal cancer treated with radiotherapy were identified. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded tissues of cases. A single pathologist analyzed the histologic specimens of all patients. Results: Totally, 67 patients were included. The median followup was 75.3 months. Higher tumor (T) stage was correlated with minichromosome maintenance complex 2 overexpression. Minichromosome maintenance complex s expression was also associated with histopathologic subgroups. According to univariate analysis, AJCC stage, histopathological subgroups, tumor response after treatment, minichromosome maintenance complex 2, 3, 5, 6 and 7 expression were the prognostic factors that predict overall survival. According to multivariate analysis minichromosome maintenance complex 7 expression was the only prognostic marker for bothprogression-free survival and overall survival. Conclusion: The overexpression of minichromosome maintenance complex 2, 3, 5, 6 and 7 indicated bad prognosis. Minichromosome maintenance complex 7 was an independent prognostic factor for survival outcomes in nasopharyngeal cancer and may be a potential therapeutic target for treatment. (c) 2021 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).en_US
dc.identifier.doi10.1016/j.bjorl.2021.05.012
dc.identifier.endpageS25en_US
dc.identifier.issn1808-8694
dc.identifier.issn1808-8686
dc.identifier.pmid34144903en_US
dc.identifier.scopus2-s2.0-85108101022en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageS18en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjorl.2021.05.012
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11670
dc.identifier.volume88en_US
dc.identifier.wosWOS:001042085800003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacialen_US
dc.relation.ispartofBrazilian Journal Of Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMinichromosome Maintenance Protein (Mcm)en_US
dc.subjectNasopharyngeal Canceren_US
dc.subjectRadiotherapyen_US
dc.subjectSurvival Outcomesen_US
dc.titlePrognostic importance of expression of mini-chromosome maintenance proteins (MCMs) in patients with nasopharyngeal cancer treated with curative radiotherapyen_US
dc.typeArticleen_US

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