Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19

Basit Öğe Kaydı
dc.contributor.authorEmsen, Ayca
dc.contributor.authorSumer, Sua
dc.contributor.authorTulek, Baykal
dc.contributor.authorCizmecioglu, Hilal
dc.contributor.authorVatansev, Husamettin
dc.contributor.authorGoktepe, Mevlut Hakan
dc.contributor.authorKanat, Fikret
dc.date.accessioned2024-02-23T14:26:07Z
dc.date.available2024-02-23T14:26:07Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe novel coronavirus disease 2019 (COVID-19) remains a global health emergency, and understanding the interactions between the virus and host immune responses is crucial to preventing its lethal effects. The expansion of myeloid-derived suppressor cells (MDSCs) in COVID-19, thereby suppressing immune responses, has been described as responsible for the severity of the disease, but the correlation between MDSC subsets and COVID-19 severity remains elusive. Therefore, we classified patients according to clinical and laboratory findings-aiming to investigate the relationship between MDSC subsets and laboratory findings such as high C-reactive protein, ferritin and lactate dehydrogenase levels, which indicate the severity of the disease. Forty-one patients with COVID-19 (26 mild and 15 severe; mean age of 49.7 +/- 15 years) and 26 healthy controls were included in this study. MDSCs were grouped into two major subsets-polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs-by flow cytometric immunophenotyping, and PMN-MDSCs were defined as mature and immature, according to CD16 expressions, for the first time in COVID-19. Total MDSCs, PMN-MDSCs, mature PMN-MDSCs and monocytic MDSCs were significantly higher in patients with COVID-19 compared with the healthy controls (P < .05). Only PMN-MDSCs and their immature PMN-MDSC subsets were higher in the severe subgroup than in the mild subgroup. In addition, a significant correlation was found between C-reactive protein, ferritin and lactate dehydrogenase levels and MDSCs in patients with COVID-19. These findings suggest that MDSCs play a role in the pathogenesis of COVID-19, while PMN-MDSCs, especially immature PMN-MDSCs, are associated with the severity of the disease.en_US
dc.description.sponsorshipScientific Research Projects Committee of Selcuk University [18611484]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Committee of Selcuk University (18611484)en_US
dc.identifier.doi10.1111/sji.13108
dc.identifier.issn0300-9475
dc.identifier.issn1365-3083
dc.identifier.issue1en_US
dc.identifier.pmid34625989en_US
dc.identifier.scopus2-s2.0-85117029030en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/sji.13108
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14050
dc.identifier.volume95en_US
dc.identifier.wosWOS:000707383200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofScandinavian Journal Of Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCovid-19en_US
dc.subjectMdsc Subsets And Acute-Phase Reactantsen_US
dc.titleCorrelation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu