Obesity Is an Independent Determinant of Ischemia-Modified Albumin

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dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorKurban, Sevil
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorPolat, Hakki
dc.date.accessioned2024-02-23T14:26:39Z
dc.date.available2024-02-23T14:26:39Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractObjective: We have measured ischemia-modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS) and high-sensitivity C-reactive protein (hsCRP) levels in obese and normal-weight subjects to investigate if IMA can be used as a biomarker of oxidative stress and inflammation and if IMA was an independent determinant of obesity or not. Methods: The study was performed on 92 obese subjects (20 male, 72 female) aged 38 +/- 11 years and 78 normal-weight controls (19 male, 59 female) aged 37 +/- 11 years. Serum lipids, IMA, TAS, TOS, and hsCRP levels of the subjects were measured. Results: IMA (p < 0.05), TOS (p < 0.001), and hsCRP (p < 0.001) levels of the obese subjects were significantly higher, whereas TAS levels were significantly lower (p < 0.05) than those of the controls after adjustment for age and gender. In the linear regression analysis, waist circumference (r(2) = 0.139, p < 0.01), BMI (r(2) = 0.136, p < 0.01) and insulin (r(2) = 0.120, p < 0.05) were shown to be significant independent determinants of IMA levels. Conclusions: We have found that oxidative stress and inflammation were increased and antioxidative defense was decreased, which resulted in increased levels of IMA, a biomarker of ischemia, in obese subjects. Also, obesity and insulin were found to be independent determinants of IMA. Thus, obese subjects are under high risk of ischemia, and IMA may be used as a biomarker of oxidative stress and ischemia. Further larger investigations are needed to confirm this opinion. Copyright (C) 2012 S. Karger GmbH, Freiburgen_US
dc.identifier.doi10.1159/000343954
dc.identifier.endpage709en_US
dc.identifier.issn1662-4025
dc.identifier.issn1662-4033
dc.identifier.issue5en_US
dc.identifier.pmid23108391en_US
dc.identifier.scopus2-s2.0-84867897219en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage700en_US
dc.identifier.urihttps://doi.org/10.1159/000343954
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14267
dc.identifier.volume5en_US
dc.identifier.wosWOS:000310577200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofObesity Factsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectIschemia-Modified Albuminen_US
dc.subjectHigh-Sensitivity C-Reactive Proteinen_US
dc.subjectTotal Antioxidant Statusen_US
dc.subjectTotal Oxidant Statusen_US
dc.titleObesity Is an Independent Determinant of Ischemia-Modified Albuminen_US
dc.typeArticleen_US

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