Liver involvement in children with Familial Mediterranean fever

Basit Öğe Kaydı
dc.contributor.authorUnal, Fatih
dc.contributor.authorCakir, Murat
dc.contributor.authorBaran, Masallah
dc.contributor.authorArikan, Cigdem
dc.contributor.authorYuksekkaya, Hasan Ali
dc.contributor.authorAydogdu, Sema
dc.date.accessioned2024-02-23T14:02:42Z
dc.date.available2024-02-23T14:02:42Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractAim: Familial Mediterranean fever is characterised by recurrent, febrile, inflammatory attacks of the serosal membranes. Prolonged inflammatory response is triggered secondary to cytokine stimulation due to reduced activity of pyrin. Inflammatory cytokines play major role in the pathogenesis of acute liver injury; and chronic, recurrent cytokine production may cause chronic hepatitis/cirrhosis. We aimed to analyse liver involvement in children with Familial Mediterranean fever. Patients: The study included 58 patients with Familial Mediterranean fever. Patients with liver involvement were examined in detail. Results: Liver involvement was seen in 11 of 58 patients (18.9%). Two patients (3.4%) had abnormal liver enzymes during the diagnostic evaluation, whilst 9 patients (15.5%) were admitted with the features of liver diseases, and had final diagnosis of Familial Mediterranean fever (2 had Budd-Chiari syndrome, Shad chronic hepatitis/cirrhosis, 2 had acute hepatitis). None of the demographic factors or laboratory findings was different between the patients with or without liver involvement M694V allele was more common in patients with liver involvement but did not reach significant difference (50% vs. 33.6%, p = 0.21). All the patients showed clinical and laboratory improvement after colchicine. Conclusion: Paediatric hepatologists must keep Familial Mediterranean fever in mind in the patients with cryptogenic hepatitis/cirrhosis especially in regions where hereditary inflammatory diseases are common. Crown Copyright (C) 2012 Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l. All rights reserved.en_US
dc.identifier.doi10.1016/j.dld.2012.01.003
dc.identifier.endpage693en_US
dc.identifier.issn1590-8658
dc.identifier.issue8en_US
dc.identifier.pmid22333476en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage689en_US
dc.identifier.urihttps://doi.org/10.1016/j.dld.2012.01.003
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11819
dc.identifier.volume44en_US
dc.identifier.wosWOS:000307744000012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofDigestive And Liver Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectLiver Involvementen_US
dc.titleLiver involvement in children with Familial Mediterranean feveren_US
dc.typeArticleen_US

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