The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group

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dc.contributor.authorTurgutalp, Kenan
dc.contributor.authorCebeci, Egemen
dc.contributor.authorTurkmen, Aydin
dc.contributor.authorDerici, Ulver
dc.contributor.authorSeyahi, Nurhan
dc.contributor.authorEren, Necmi
dc.contributor.authorDede, Fatih
dc.date.accessioned2024-02-23T14:27:17Z
dc.date.available2024-02-23T14:27:17Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = - 0.084, r = - 0.102, r = - 0.006, r = 0.062, r = 0.014, r = - 0.044, r = - 0.061, r = - 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.en_US
dc.description.sponsorshipTurkish Society of Nephrologyen_US
dc.description.sponsorshipFinancial supports (establishing the registry database) have been obtained from the Turkish Society of Nephrology.en_US
dc.identifier.doi10.1186/s12882-021-02560-2
dc.identifier.issn1471-2369
dc.identifier.issue1en_US
dc.identifier.pmid34711174en_US
dc.identifier.scopus2-s2.0-85117893002en_US
dc.identifier.urihttps://doi.org/10.1186/s12882-021-02560-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14534
dc.identifier.volume22en_US
dc.identifier.wosWOS:000712386500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIga Nephropathyen_US
dc.subjectGlomerular Igg Stainingen_US
dc.subjectRenal Prognostic Factorsen_US
dc.titleThe relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working groupen_US
dc.typeArticleen_US

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