The relation between ischemia modified albumin levels and carotid intima media thickness in patients with rheumatoid arthritis

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dc.contributor.authorUslu, Ali U.
dc.contributor.authorKucuk, Adem
dc.contributor.authorBalta, Sevket
dc.contributor.authorOzturk, Cengiz
dc.contributor.authorArslan, Sevket
dc.contributor.authorTekin, Levent
dc.contributor.authorKucuksen, Sami
dc.date.accessioned2024-02-23T14:24:00Z
dc.date.available2024-02-23T14:24:00Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBackground Cardiovascular diseases, among which atherosclerotic heart disease, are known to be one of the most important mortality and morbidity causes in patients with rheumatoid arthritis (RA). Ischemia modified albumin (IMA) is a potential marker that can be used to assess atherosclerosis-related myocardial ischemia. Another frequently used marker for the assessment of atherosclerotic lesions is the carotid intima media thickness (CIMT). Aim To evaluate the role that IMA has on atherosclerosis development and its clinical usability in patients with RA, by assessing the values of IMA and CIMT. Methods and materials Our prospective study was conducted between June 2012 and March 2013 at the Rheumatology Department of Necmettin Erbakan Meram Medical School, Turkey. Fifty-two RA patients, diagnosed according to the 1987 criteria of the American College of Rheumatology, and an age- and sex-matched control group of 46 healthy subjects were included in this study. Results No significant difference was detected between the groups with respect to age, sex and body mass index. In the patient group the IMA and CIMT values were found to be 0.37 +/- 0.12 absorbance units (ABSU) and 0.80 +/- 0.22 mm, respectively, while in the control group they were 0.31 +/- 0.11 ABSU and 0.51 +/- 0.18 mm, respectively. The IMA and CIMT values were significantly higher in the patient group (P = 0.022 and P < 0.0001, respectively). A positive correlation was found between IMA, CIMT and Disease Activity Score of 28 joints (P = 0.016 and P = 0.002, respectively). Conclusion Since the values of IMA were higher in the patient group compared to controls and because of its correlation with CIMT, we suggest the use of IMA as an early marker of atherosclerosis in RA patients.en_US
dc.identifier.doi10.1111/1756-185X.12851
dc.identifier.endpage37en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue1en_US
dc.identifier.pmid27028097en_US
dc.identifier.scopus2-s2.0-84962745008en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.12851
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13763
dc.identifier.volume22en_US
dc.identifier.wosWOS:000457062500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectCarotid Intima Media Thicknessen_US
dc.subjectIschemia Modified Albuminen_US
dc.subjectRheumatoid Arthritisen_US
dc.titleThe relation between ischemia modified albumin levels and carotid intima media thickness in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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