Neutrophil-to-lymphocyte ratio is involved in the severity of ankylosing spondylitis

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dc.contributor.authorKucuk, A.
dc.contributor.authorUslu, A. U.
dc.contributor.authorUgan, Y.
dc.contributor.authorBagcaci, S.
dc.contributor.authorKarahan, A. Y.
dc.contributor.authorAkannut, A.
dc.contributor.authorSahin, A.
dc.date.accessioned2024-02-23T14:37:58Z
dc.date.available2024-02-23T14:37:58Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE: Ankylosing spondylitis (AS) is a progressive chronic inflammatory disease mainly characterized by axial skeleton and sacroiliac joint involvement. We aimed to investigate the relation between neutrophil-to-lymphocyte ratio (NLR) and disease severity of AS and to explore its availability in clinical practice. METHODS: A total of 102 AS patients and 60 individuals who were age- and gender-compatible with the control group were included into the study. Patients were divided into 2 groups according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores. Patients with BASDAI scores <4 were considered to be having mild disease activity, whereas those with scores 4 were considered to be displaying severe disease activity. Hemogram test during the diagnosis, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and other laboratory values of the control group were recorded. RESULTS: NLR was observed to be higher in AS patients compared to the controls (2.47 +/- 1.33 and 1.72 +/- 0.47; respectively; p<0.0001). NLR was observed to be significantly higher in severe AS disease activity compared to the mild AS disease activity (2.72 +/- 1.41, 2.20 +/- 1.19; respectively; p = 0.001). NLR had statistical significant differences between mild disease activity compared to the controls (2.20 +/- 1.19 and 1.72 +/- 0.47, respectively; p = 0.263). There was a positive correlation between NLR and BASDAI (r = 0.193, p = 0.041). The performance of NLR evaluating the disease severity by Roc analysis had sensitivity of 69%, specificity of 54% (cut-off value 1.91), and AUC of 0.652 (95% Cl, 0.549-0.755) (p = 0.006). CONCLUSIONS: NLR may be a simple and inexpensive marker to indicate disease activity in patients with AS in daily clinical practice (Tab. 3, Fig. 3, Ref. 25). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2015_142
dc.identifier.endpage725en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12en_US
dc.identifier.pmid26924141en_US
dc.identifier.scopus2-s2.0-84973279094en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage722en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_142
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16316
dc.identifier.volume116en_US
dc.identifier.wosWOS:000367280800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectBasdaien_US
dc.subjectDiseaseen_US
dc.subjectNeutrophil-To-Lymphocyte Ratioen_US
dc.subjectSeverityen_US
dc.titleNeutrophil-to-lymphocyte ratio is involved in the severity of ankylosing spondylitisen_US
dc.typeArticleen_US

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