Investigation of the protective effect of acetazolamide and SLC-0111 on carbon tetrachloride-induced toxicity in fruit fly

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dc.contributor.authorGunes, Eda
dc.contributor.authorAydin, Hasan
dc.contributor.authorNizamlioglu, Hatice Ferhan
dc.date.accessioned2024-02-23T14:16:23Z
dc.date.available2024-02-23T14:16:23Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractSulfonamide-based compounds in the development of drugs used in cancer treatment have been started to be investigated recently. In the current work, it was determined the protective effect of Acetazolamide (AAZ) and SLC-0111 on carbon tetrachloride-induced toxicity in the fruit fly (Drosophila melanogaster). AAZ and SLC-0111 were used as a nonselective and selective inhibitor of carbonic anhydrase isozymes, respectively, to compare the selectivity effect of drugs on toxicity. The experimental toxicity was created by carbon tetrachloride (CCl4) that causes tissue damage to the first stage larvae of fruit fly and used as a model organism. The effect of AAZ and SLC-0111 on toxicity of insect survival, sex ratio, longevity and some biochemical parameters such as Malondialdehyde-MDA content, Superoxide dismutase-SOD and Glutathione-S-transferase-GST activity were tested. According to the data obtained, feeding of insects with AAZ and SLC-0111 (2.5 and 10 mM, respectively) affected their survival and development positively against the toxicity induced by CCl4. Compared to the control group, GST and SOD activity was higher in pups and adults (SLC-0111 < AAZ). Because of this study, SLC-0111 is thought to be useful in protecting against the harmful effects of reactive oxygen species.en_US
dc.identifier.doi10.1016/j.toxrep.2021.06.014
dc.identifier.endpage1304en_US
dc.identifier.issn2214-7500
dc.identifier.pmid34221901en_US
dc.identifier.scopus2-s2.0-85109586678en_US
dc.identifier.startpage1300en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxrep.2021.06.014
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12649
dc.identifier.volume8en_US
dc.identifier.wosWOS:000702915900005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofToxicology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbon Tetrachlorideen_US
dc.subjectDrosophila Melanogasteren_US
dc.subjectLongevityen_US
dc.subjectMalondialdehydeen_US
dc.subjectSuperoxide Dismutaseen_US
dc.titleInvestigation of the protective effect of acetazolamide and SLC-0111 on carbon tetrachloride-induced toxicity in fruit flyen_US
dc.typeArticleen_US

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