Ophthalmic manifestations in recently diagnosed childhood leukemia

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorBelviranli, Selman
dc.contributor.authorCaliskan, Umran
dc.contributor.authorTokgoz, Huseyin
dc.contributor.authorOzkagnici, Ahmet
dc.contributor.authorZengin, Nazmi
dc.date.accessioned2024-02-23T14:41:30Z
dc.date.available2024-02-23T14:41:30Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractPurpose: To determine the prevalence and the pattern of ocular involvement in children with leukemia at the time of diagnosis. Methods: The data of patients with leukemia who underwent complete ophthalmic examination at the time of diagnosis between January 2005 and December 2014 were retrospectively reviewed. Demographic data, type of leukemia, ocular findings, blood parameters, and duration of follow-up were analyzed. Results: A total of 185 patients (111 male and 74 female) were included in the study, with a median age of 6.0 years (range 0.5-18.0 years) and a median follow-up time of 36.0 months (range 0.5-108.0 months). Ocular signs were present in 24.3% of the patients at the time of diagnosis and 37.8% of them were symptomatic. The prevalence of ocular involvement was 20.4% in patients with acute lymphocytic leukemia (ALL) and 36.4% in patients with acute myelocytic leukemia (AML) (p = 0.051). Fatality rate was significantly higher in subjects with AML compared with ALL (p = 0.019), but was not significantly different between patients with and without ocular involvement (p = 0.166). There were no significant differences in hemoglobin levels, white blood cell counts, or platelet counts between patients with ALL and AML. Platelet counts were significantly lower in patients with ocular signs compared with subjects without ocular involvement (p = 0.012), while hemoglobin levels and white blood cell counts did not differ significantly. Conclusions: Various ocular signs may be present at the time of diagnosis in childhood leukemia, even in patients without any symptoms. Routine ophthalmic examination should be performed in recently diagnosed children with leukemia.en_US
dc.identifier.doi10.5301/ejo.5000647
dc.identifier.endpage91en_US
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue1en_US
dc.identifier.pmid26165325en_US
dc.identifier.scopus2-s2.0-84954069800en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://doi.org/10.5301/ejo.5000647
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16862
dc.identifier.volume26en_US
dc.identifier.wosWOS:000372258400016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofEuropean Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEye Manifestationsen_US
dc.subjectLeukemiaen_US
dc.subjectRetinal Hemorrhagesen_US
dc.titleOphthalmic manifestations in recently diagnosed childhood leukemiaen_US
dc.typeArticleen_US

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